| The molecular basis for tropomyosin isoform diversity JP Lees‐Miller, DM Helfman Bioessays 13 (9), 429-437, 1991 | 454 | 1991 |
| Molecular determinant of high-affinity dofetilide binding toHERG1 expressed in Xenopus oocytes: involvement of S6 sites JP Lees-Miller, Y Duan, GQ Teng, HJ Duff Molecular pharmacology 57 (2), 367-374, 2000 | 306 | 2000 |
| Electrophysiological Characterization of an Alternatively Processed ERG K+ Channel in Mouse and Human Hearts JP Lees-Miller, C Kondo, L Wang, HJ Duff Circulation Research 81 (5), 719-726, 1997 | 258 | 1997 |
| A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility JP Lees-Miller, DM Helfman, TA Schroer Nature 359 (6392), 244-246, 1992 | 231 | 1992 |
| The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin‐1β NA Bracey, PL Beck, DA Muruve, SA Hirota, J Guo, H Jabagi, JR Wright Jr, ... Experimental physiology 98 (2), 462-472, 2013 | 195 | 2013 |
| Isolation and characterization of an abundant and novel 22-kDa protein (SM22) from chicken gizzard smooth muscle. JP Lees-Miller, DH Heeley, LB Smillie, CM Kay Journal of Biological Chemistry 262 (7), 2988-2993, 1987 | 152 | 1987 |
| An abundant and novel protein of 22 kDa (SM22) is widely distributed in smooth muscles. Purification from bovine aorta JP Lees-Miller, DH Heeley, LB Smillie Biochemical Journal 244 (3), 705-709, 1987 | 148 | 1987 |
| Three novel brain tropomyosin isoforms are expressed from the rat α-tropomyosin gene through the use of alternative promoters and alternative RNA processing JP Lees-Miller, LO Goodwin, DM Helfman Molecular and cellular biology 10 (4), 1729-1742, 1990 | 145 | 1990 |
| Identification of act2, an essential gene in the fission yeast Schizosaccharomyces pombe that encodes a protein related to actin. JP Lees-Miller, G Henry, DM Helfman Proceedings of the National Academy of Sciences 89 (1), 80-83, 1992 | 116 | 1992 |
| Novel Gain-of-Function Mechanism in K+ Channel–Related Long-QT Syndrome: Altered Gating and Selectivity in the HERG1 N629D Mutant JP Lees-Miller, Y Duan, GQ Teng, K Thorstad, HJ Duff Circulation research 86 (5), 507-513, 2000 | 114 | 2000 |
| Overexpression of calcineurin in mouse causes sudden cardiac death associated with decreased density of K+ channels D Dong, Y Duan, J Guo, DE Roach, SL Swirp, L Wang, JP Lees-Miller, ... Cardiovascular research 57 (2), 320-332, 2003 | 83 | 2003 |
| Four fibroblast tropomyosin isoforms are expressed from the rat alpha-tropomyosin gene via alternative RNA splicing and the use of two promoters LO Goodwin, JP Lees-Miller, MA Leonard, SB Cheley, DM Helfman Journal of Biological Chemistry 266 (13), 8408-8415, 1991 | 82 | 1991 |
| Selective Knockout of Mouse ERG1 B Potassium Channel Eliminates IKr in Adult Ventricular Myocytes and Elicits Episodes of Abrupt Sinus Bradycardia JP Lees-Miller, J Guo, JR Somers, DE Roach, RS Sheldon, DE Rancourt, ... Molecular and cellular biology 23 (6), 1856-1862, 2003 | 71 | 2003 |
| Amino acid sequence of chicken gizzard smooth muscle SM22 alpha. JR Pearlstone, M Weber, JP Lees-Miller, MR Carpenter, LB Smillie Journal of Biological Chemistry 262 (13), 5985-5991, 1987 | 67 | 1987 |
| Homozygous missense N629D hERG (KCNH2) potassium channel mutation causes developmental defects in the right ventricle and its outflow tract and embryonic lethality GQ Teng, X Zhao, JP Lees-Miller, FR Quinn, P Li, DE Rancourt, B London, ... Circulation research 103 (12), 1483-1491, 2008 | 63 | 2008 |
| Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4 JP Lees-Miller, J Guo, Y Wang, LL Perissinotti, SY Noskov, HJ Duff Journal of molecular and cellular cardiology 85, 71-78, 2015 | 62 | 2015 |
| Structural refinement of the hERG1 pore and voltage‐sensing domains with ROSETTA‐membrane and molecular dynamics simulations J Subbotina, V Yarov‐Yarovoy, J Lees‐Miller, S Durdagi, J Guo, HJ Duff, ... Proteins: Structure, Function, and Bioinformatics 78 (14), 2922-2934, 2010 | 62 | 2010 |
| Insights into the molecular mechanism of hERG1 channel activation and blockade by drugs S Durdagi, J Subbotina, J Lees-Miller, J Guo, H J Duff, S Y Noskov Current medicinal chemistry 17 (30), 3514-3532, 2010 | 58 | 2010 |
| Exaggerated block of hERG (KCNH2) and prolongation of action potential duration by erythromycin at temperatures between 37 C and 42 C J Guo, S Zhan, JP Lees-Miller, GQ Teng, HJ Duff Heart Rhythm 2 (8), 860-866, 2005 | 56 | 2005 |
| Brain-specific tropomyosins TMBr-1 and TMBr-3 have distinct patterns of expression during development and in adult brain. S Stamm, D Casper, JP Lees-Miller, DM Helfman Proceedings of the National Academy of Sciences 90 (21), 9857-9861, 1993 | 54 | 1993 |
