Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells NN Khodarev, AJ Minn, EV Efimova, TE Darga, E Labay, M Beckett, ... Cancer research 67 (19), 9214-9220, 2007 | 161 | 2007 |
Poly (ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors EV Efimova, HJ Mauceri, DW Golden, E Labay, VP Bindokas, TE Darga, ... Cancer research 70 (15), 6277-6282, 2010 | 130 | 2010 |
Nrf2 is an inhibitor of the Fas pathway as identified by Achilles' Heel Method, a new function-based approach to gene identification in human cells KU Kotlo, F Yehiely, E Efimova, H Harasty, B Hesabi, K Shchors, P Einat, ... Oncogene 22 (6), 797-806, 2003 | 101 | 2003 |
Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation JC Barreto-Andrade, EV Efimova, HJ Mauceri, MA Beckett, HG Sutton, ... Molecular cancer therapeutics 10 (7), 1185-1193, 2011 | 87 | 2011 |
Radiation-inducible immunotherapy for cancer: senescent tumor cells as a cancer vaccine Y Meng, EV Efimova, KW Hamzeh, TE Darga, HJ Mauceri, YX Fu, SJ Kron, ... Molecular therapy 20 (5), 1046-1055, 2012 | 84 | 2012 |
Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor α-induced apoptosis and activation of caspase-8 and-3 AM Al-Zoubi, EV Efimova, S Kaithamana, O Martinez, MEA El-Idrissi, ... Journal of Biological Chemistry 276 (50), 47202-47211, 2001 | 75 | 2001 |
Radioresistance of Stat1 over-expressing tumour cells is associated with suppressed apoptotic response to cytotoxic agents and increased IL6-IL8 signalling EV Efimova, EV Efimova, H Liang, SP Pitroda, E Labay, TE Darga, ... International journal of radiation biology 85 (5), 421-431, 2009 | 63 | 2009 |
Linking cancer metabolism to DNA repair and accelerated senescence EV Efimova, S Takahashi, NA Shamsi, D Wu, E Labay, OA Ulanovskaya, ... Molecular cancer research 14 (2), 173-184, 2016 | 51 | 2016 |
IG20, in contrast to DENN-SV,(MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs EV Efimova, AM Al-Zoubi, O Martinez, S Kaithamana, S Lu, T Arima, ... Oncogene 23 (5), 1076-1087, 2004 | 50 | 2004 |
IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC M Ramaswamy, EV Efimova, O Martinez, NU Mulherkar, SP Singh, ... Oncogene 23 (36), 6083-6094, 2004 | 47 | 2004 |
HMG-CoA reductase inhibition delays DNA repair and promotes senescence after tumor irradiation EV Efimova, N Ricco, E Labay, HJ Mauceri, AC Flor, A Ramamurthy, ... Molecular cancer therapeutics 17 (2), 407-418, 2018 | 45 | 2018 |
Gene identification method LP Deiss, F Yehiely, E Efimova, NC Vasquez-Iaslop, P Einat US Patent 6,057,111, 2000 | 34 | 2000 |
O-GlcNAcylation enhances double-strand break repair, promotes cancer cell proliferation, and prevents therapy-induced senescence in irradiated tumors EV Efimova, OK Appelbe, N Ricco, SSY Lee, Y Liu, DJ Wolfgeher, ... Molecular Cancer Research 17 (6), 1338-1350, 2019 | 32 | 2019 |
Translational strategies exploiting TNF-α that sensitize tumors to radiation therapy HJ Mauceri, MA Beckett, H Liang, HG Sutton, S Pitroda, E Galka, ... Cancer gene therapy 16 (4), 373-381, 2009 | 31 | 2009 |
Imaging UVC‐induced DNA damage response in models of minimal cancer S Miwa, S Yano, Y Hiroshima, Y Tome, F Uehara, S Mii, EV Efimova, ... Journal of cellular biochemistry 114 (11), 2493-2499, 2013 | 29 | 2013 |
Comparison of UVB and UVC effects on the DNA damage‐response protein 53BP1 in human pancreatic cancer F Uehara, S Miwa, Y Tome, Y Hiroshima, S Yano, M Yamamoto, ... Journal of cellular biochemistry 115 (10), 1724-1728, 2014 | 26 | 2014 |
Dynamic color‐coded fluorescence imaging of the cell‐cycle phase, mitosis, and apoptosis demonstrates how caffeine modulates cisplatinum efficacy S Miwa, S Yano, Y Tome, N Sugimoto, Y Hiroshima, F Uehara, S Mii, ... Journal of Cellular Biochemistry 114 (11), 2454-2460, 2013 | 26 | 2013 |
IG20, a MADD splice variant, increases cell susceptibility to γ-irradiation and induces soluble mediators that suppress tumor cell growth E Efimova, O Martinez, A Lokshin, T Arima, BS Prabhakar Cancer Research 63 (24), 8768-8776, 2003 | 25 | 2003 |
Repair-independent functions of DNA-PKcs protect irradiated cells from mitotic slippage and accelerated senescence Y Liu, EV Efimova, A Ramamurthy, SJ Kron Journal of Cell Science 132 (13), jcs229385, 2019 | 24 | 2019 |
Repurposing cephalosporin antibiotics as pro-senescent radiosensitizers E Labay, HJ Mauceri, E Elena V, AC Flor, HG Sutton, K Stephen J, ... Oncotarget, 2016 | 22 | 2016 |