Jonathan DF Wadsworth
Jonathan DF Wadsworth
MRC Investigator, MRC Prion Unit at UCL
Verified email at - Homepage
Cited by
Cited by
Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay
JDF Wadsworth, S Joiner, AF Hill, TA Campbell, M Desbruslais, ...
The Lancet 358 (9277), 171-180, 2001
Clinical presentation and pre-mortem diagnosis of variant Creutzfeldt-Jakob disease associated with blood transfusion: a case report
SJ Wroe, S Pal, D Siddique, H Hyare, R Macfarlane, S Joiner, JM Linehan, ...
The Lancet 368 (9552), 2061-2067, 2006
BSE prions propagate as either variant CJD‐like or sporadic CJD‐like prion strains in transgenic mice expressing human prion protein
EA Asante, JM Linehan, M Desbruslais, S Joiner, I Gowland, AL Wood, ...
The EMBO journal 21 (23), 6358-6366, 2002
Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy
Z Jaunmuktane, S Mead, M Ellis, JDF Wadsworth, AJ Nicoll, J Kenny, ...
Nature 525 (7568), 247-250, 2015
Strain-specific prion-protein conformation determined by metal ions
JDF Wadsworth, AF Hill, S Joiner, GS Jackson, AR Clarke, J Collinge
Nature cell biology 1 (1), 55-59, 1999
Molecular classification of sporadic Creutzfeldt–Jakob disease
AF Hill, S Joiner, JDF Wadsworth, KCL Sidle, JE Bell, H Budka, ...
Brain 126 (6), 1333-1346, 2003
Human prion protein with valine 129 prevents expression of variant CJD phenotype
JDF Wadsworth, EA Asante, M Desbruslais, JM Linehan, S Joiner, ...
Science 306 (5702), 1793-1796, 2004
Molecular and clinical classification of human prion disease
JDF Wadsworth, AF Hill, JA Beck, J Collinge
British medical bulletin 66 (1), 241-254, 2003
Disease-related prion protein forms aggresomes in neuronal cells leading to caspase activation and apoptosis
M Kristiansen, MJ Messenger, PC Klöhn, S Brandner, JDF Wadsworth, ...
Journal of Biological Chemistry 280 (46), 38851-38861, 2005
A naturally occurring variant of the human prion protein completely prevents prion disease
EA Asante, M Smidak, A Grimshaw, R Houghton, A Tomlinson, A Jeelani, ...
Nature 522 (7557), 478-481, 2015
Detection and characterization of proteinase K-sensitive disease-related prion protein with thermolysin
S Cronier, N Gros, MH Tattum, GS Jackson, AR Clarke, J Collinge, ...
Biochemical Journal 416 (2), 297-305, 2008
Neurotransmitter release is blocked intracellularly by botulinum neurotoxin, and this requires uptake of both toxin polypeptides by a process mediated by the larger chain
B Poulain, L Tauc, EA Maisey, JD Wadsworth, PM Mohan, JO Dolly
Proceedings of the National Academy of Sciences 85 (11), 4090-4094, 1988
Update on human prion disease
JDF Wadsworth, J Collinge
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1772 (6), 598-609, 2007
Chronic wasting disease prions are not transmissible to transgenic mice overexpressing human prion protein
MK Sandberg, H Al-Doujaily, CJ Sigurdson, M Glatzel, C O'Malley, ...
The Journal of general virology 91 (Pt 10), 2651, 2010
A novel prion disease associated with diarrhea and autonomic neuropathy
S Mead, S Gandhi, J Beck, D Caine, D Gajulapalli, C Carswell, H Hyare, ...
New England Journal of Medicine 369 (20), 1904-1914, 2013
Inherited prion disease with six octapeptide repeat insertional mutation—molecular analysis of phenotypic heterogeneity
S Mead, M Poulter, J Beck, TEF Webb, TA Campbell, JM Linehan, ...
Brain 129 (9), 2297-2317, 2006
Phenotypic heterogeneity and genetic modification of P102L inherited prion disease in an international series
TEF Webb, M Poulter, J Beck, J Uphill, G Adamson, T Campbell, ...
Brain 131 (10), 2632-2646, 2008
Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity
AJ Nicoll, S Panico, DB Freir, D Wright, C Terry, E Risse, CE Herron, ...
Nature communications 4 (1), 1-9, 2013
Distinct glycoform ratios of protease resistant prion protein associated with PRNP point mutations
AF Hill, S Joiner, JA Beck, TA Campbell, A Dickinson, M Poulter, ...
Brain 129 (3), 676-685, 2006
Variant Creutzfeldt-Jakob disease in a patient with heterozygosity at PRNP codon 129
T Mok, Z Jaunmuktane, S Joiner, T Campbell, C Morgan, B Wakerley, ...
The New England journal of medicine 376 (3), 292-294, 2017
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