Ancestral protein reconstruction yields insights into adaptive evolution of binding specificity in solute-binding proteins BE Clifton, CJ Jackson Cell chemical biology 23 (2), 236-245, 2016 | 97 | 2016 |
Evolution of cyclohexadienyl dehydratase from an ancestral solute-binding protein BE Clifton, JA Kaczmarski, PD Carr, ML Gerth, N Tokuriki, CJ Jackson Nature chemical biology 14 (6), 542-547, 2018 | 94 | 2018 |
Construction of a robust and sensitive arginine biosensor through ancestral protein reconstruction JH Whitfield, WH Zhang, MK Herde, BE Clifton, J Radziejewski, ... Protein Science 24 (9), 1412-1422, 2015 | 73 | 2015 |
Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity NW Zammit, OM Siggs, PE Gray, K Horikawa, DB Langley, SN Walters, ... Nature immunology 20 (10), 1299-1310, 2019 | 53 | 2019 |
T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein CR Fisher, HJ Sutton, JA Kaczmarski, HA McNamara, B Clifton, J Mitchell, ... PLoS pathogens 13 (7), e1006469, 2017 | 49 | 2017 |
Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme JA Kaczmarski, MC Mahawaththa, A Feintuch, BE Clifton, LA Adams, ... Nature communications 11 (1), 5945, 2020 | 37 | 2020 |
Efficient exploration of sequence space by sequence-guided protein engineering and design BE Clifton, D Kozome, P Laurino Biochemistry 62 (2), 210-220, 2022 | 13 | 2022 |
Structural reconstruction of protein ancestry R Rouet, DB Langley, P Schofield, M Christie, B Roome, BT Porebski, ... Proceedings of the National Academy of Sciences 114 (15), 3897-3902, 2017 | 11 | 2017 |
Evolutionary repair reveals an unexpected role of the tRNA modification m1G37 in aminoacylation BE Clifton, MA Fariz, GI Uechi, P Laurino Nucleic Acids Research, 2021 | 9 | 2021 |
Ancestral protein reconstruction and circular permutation for improving the stability and dynamic range of FRET Sensors BE Clifton, JH Whitfield, I Sanchez-Romero, MK Herde, C Henneberger, ... Synthetic Protein Switches: Methods and Protocols, 71-87, 2017 | 9 | 2017 |
High avidity drives the interaction between the streptococcal C1 phage endolysin, PlyC, with the cell surface carbohydrates of Group A Streptococcus SS Broendum, DE Williams, BK Hayes, F Kraus, J Fodor, BE Clifton, ... Molecular microbiology 116 (2), 397-415, 2021 | 8 | 2021 |
The role of oligomerization in the optimization of cyclohexadienyl dehydratase conformational dynamics and catalytic activity NJ East, BE Clifton, CJ Jackson, JA Kaczmarski Protein Science 31 (12), e4510, 2022 | 4 | 2022 |
Ultrahigh-affinity transport proteins from ubiquitous marine bacteria reveal mechanisms and global patterns of nutrient uptake BE Clifton, U Alcolombri, CJ Jackson, P Laurino bioRxiv, 2023.02. 16.528805, 2023 | | 2023 |
SUPREM: an engineered non-site-specific m6A RNA methyltransferase with highly improved efficiency Y Ochiai, BE Clifton, ML Coz, M Terenzio, P Laurino bioRxiv, 2023.08. 23.554385, 2023 | | 2023 |
Anti peptide-HLA (TCR-like) antibodies specific for the KRAS G12V neoantigen A Maserati, D Makris, B Kiefel, M Beasley, B McColl, B Clifton Molecular Cancer Research 18 (5 Supplement), PR04-PR04, 2020 | | 2020 |