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Ben E. Clifton
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Year
Ancestral protein reconstruction yields insights into adaptive evolution of binding specificity in solute-binding proteins
BE Clifton, CJ Jackson
Cell chemical biology 23 (2), 236-245, 2016
972016
Evolution of cyclohexadienyl dehydratase from an ancestral solute-binding protein
BE Clifton, JA Kaczmarski, PD Carr, ML Gerth, N Tokuriki, CJ Jackson
Nature chemical biology 14 (6), 542-547, 2018
942018
Construction of a robust and sensitive arginine biosensor through ancestral protein reconstruction
JH Whitfield, WH Zhang, MK Herde, BE Clifton, J Radziejewski, ...
Protein Science 24 (9), 1412-1422, 2015
732015
Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity
NW Zammit, OM Siggs, PE Gray, K Horikawa, DB Langley, SN Walters, ...
Nature immunology 20 (10), 1299-1310, 2019
532019
T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein
CR Fisher, HJ Sutton, JA Kaczmarski, HA McNamara, B Clifton, J Mitchell, ...
PLoS pathogens 13 (7), e1006469, 2017
492017
Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme
JA Kaczmarski, MC Mahawaththa, A Feintuch, BE Clifton, LA Adams, ...
Nature communications 11 (1), 5945, 2020
372020
Efficient exploration of sequence space by sequence-guided protein engineering and design
BE Clifton, D Kozome, P Laurino
Biochemistry 62 (2), 210-220, 2022
132022
Structural reconstruction of protein ancestry
R Rouet, DB Langley, P Schofield, M Christie, B Roome, BT Porebski, ...
Proceedings of the National Academy of Sciences 114 (15), 3897-3902, 2017
112017
Evolutionary repair reveals an unexpected role of the tRNA modification m1G37 in aminoacylation
BE Clifton, MA Fariz, GI Uechi, P Laurino
Nucleic Acids Research, 2021
92021
Ancestral protein reconstruction and circular permutation for improving the stability and dynamic range of FRET Sensors
BE Clifton, JH Whitfield, I Sanchez-Romero, MK Herde, C Henneberger, ...
Synthetic Protein Switches: Methods and Protocols, 71-87, 2017
92017
High avidity drives the interaction between the streptococcal C1 phage endolysin, PlyC, with the cell surface carbohydrates of Group A Streptococcus
SS Broendum, DE Williams, BK Hayes, F Kraus, J Fodor, BE Clifton, ...
Molecular microbiology 116 (2), 397-415, 2021
82021
The role of oligomerization in the optimization of cyclohexadienyl dehydratase conformational dynamics and catalytic activity
NJ East, BE Clifton, CJ Jackson, JA Kaczmarski
Protein Science 31 (12), e4510, 2022
42022
Ultrahigh-affinity transport proteins from ubiquitous marine bacteria reveal mechanisms and global patterns of nutrient uptake
BE Clifton, U Alcolombri, CJ Jackson, P Laurino
bioRxiv, 2023.02. 16.528805, 2023
2023
SUPREM: an engineered non-site-specific m6A RNA methyltransferase with highly improved efficiency
Y Ochiai, BE Clifton, ML Coz, M Terenzio, P Laurino
bioRxiv, 2023.08. 23.554385, 2023
2023
Anti peptide-HLA (TCR-like) antibodies specific for the KRAS G12V neoantigen
A Maserati, D Makris, B Kiefel, M Beasley, B McColl, B Clifton
Molecular Cancer Research 18 (5 Supplement), PR04-PR04, 2020
2020
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