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Jerome Wielens
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Oncogenic protein interfaces: small molecules, big challenges
TL Nero, CJ Morton, JK Holien, J Wielens, MW Parker
Nature Reviews Cancer 14 (4), 248-262, 2014
3372014
Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA
DB Ascher, J Wielens, TL Nero, L Doughty, CJ Morton, MW Parker
Scientific reports 4 (1), 4765, 2014
1322014
Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?
J Wielens, SJ Headey, DI Rhodes, RJ Mulder, O Dolezal, JJ Deadman, ...
Journal of Biomolecular Screening 18 (2), 147-159, 2013
812013
The structure of the bacterial oxidoreductase enzyme DsbA in complex with a peptide reveals a basis for substrate specificity in the catalytic cycle of DsbA enzymes
JJ Paxman, NA Borg, J Horne, PE Thompson, Y Chin, P Sharma, ...
Journal of biological chemistry 284 (26), 17835-17845, 2009
812009
A three-dimensional model of the human immunodeficiency virus type 1 integration complex
J Wielens, IT Crosby, DK Chalmers
Journal of computer-aided molecular design 19, 301-317, 2005
752005
The interaction of lipophilic drugs with intestinal fatty acid-binding protein
T Velkov, S Chuang, J Wielens, H Sakellaris, WN Charman, CJH Porter, ...
Journal of Biological Chemistry 280 (18), 17769-17776, 2005
632005
Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site
J Wielens, SJ Headey, D Jeevarajah, DI Rhodes, J Deadman, ...
FEBS letters 584 (8), 1455-1462, 2010
502010
Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation
A Quan, J Xue, J Wielens, KJ Smillie, V Anggono, MW Parker, MA Cousin, ...
Proceedings of the National Academy of Sciences 109 (10), 3760-3765, 2012
342012
Fragment‐Based Design of Ligands Targeting a Novel Site on the Integrase Enzyme of Human Immunodeficiency Virus 1
J Wielens, SJ Headey, JJ Deadman, DI Rhodes, MW Parker, ...
ChemMedChem 6 (2), 258-261, 2011
342011
Fragment‐Based Design of Ligands Targeting a Novel Site on the Integrase Enzyme of Human Immunodeficiency Virus 1
J Wielens, SJ Headey, JJ Deadman, DI Rhodes, MW Parker, ...
ChemMedChem 6 (2), 258-261, 2011
342011
The binding of syndapin SH3 domain to dynamin proline-rich domain involves short and long distance elements
L Luo, J Xue, A Kwan, R Gamsjaeger, J Wielens, L von Kleist, L Cubeddu, ...
Journal of Biological Chemistry 291 (18), 9411-9424, 2016
302016
Characterization of two distinct modes of drug binding to human intestinal fatty acid binding protein
R Patil, A Laguerre, J Wielens, SJ Headey, ML Williams, MLR Hughes, ...
ACS chemical biology 9 (11), 2526-2534, 2014
292014
Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis
JP Vivian, J Scoullar, AL Robertson, SP Bottomley, J Horne, Y Chin, ...
Journal of biological chemistry 283 (47), 32452-32461, 2008
282008
Probing the fibrate binding specificity of rat liver fatty acid binding protein
S Chuang, T Velkov, J Horne, J Wielens, DK Chalmers, CJH Porter, ...
Journal of medicinal chemistry 52 (17), 5344-5355, 2009
212009
Diuretic drug binding to human glutathione transferase P1‐1: potential role of Cys‐101 revealed in the double mutant C47S/Y108V
I Quesada‐Soriano, LJ Parker, A Primavera, J Wielens, JK Holien, ...
Journal of Molecular Recognition 24 (2), 220-234, 2011
152011
Propargyloxyproline regio-and stereoisomers for click-conjugation of peptides: synthesis and application in linear and cyclic peptides
SE Northfield, SJ Mountford, J Wielens, M Liu, L Zhang, H Herzog, ...
Australian Journal of Chemistry 68 (9), 1365-1372, 2015
122015
Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA. Sci Rep 4: 4765
DB Ascher, J Wielens, TL Nero, L Doughty, CJ Morton, MW Parker
92014
Cyclic Hexapeptide Mimics of the LEDGF Integrase Recognition Loop in Complex with HIV‐1 Integrase
SE Northfield, J Wielens, SJ Headey, BJ Williams‐Noonan, M Mulcair, ...
ChemMedChem 13 (15), 1555-1565, 2018
82018
Preparation, crystallization and preliminary X-ray diffraction analysis of two intestinal fatty-acid binding proteins in the presence of 11-(dansylamino) undecanoic acid
A Laguerre, J Wielens, MW Parker, CJH Porter, MJ Scanlon
Acta Crystallographica Section F: Structural Biology and Crystallization …, 2011
82011
NS5A-P32 deletion in hepatitis C genotype 1b infection is the most refractory treatment-mediated amino acid change exhibiting resistance to all NS5A inhibitors
H Hikita, T Takehara
Seminars in Liver Disease 40 (02), 143-153, 2020
62020
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