| Oncogenic protein interfaces: small molecules, big challenges TL Nero, CJ Morton, JK Holien, J Wielens, MW Parker Nature Reviews Cancer 14 (4), 248-262, 2014 | 365 | 2014 |
| Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA DB Ascher, J Wielens, TL Nero, L Doughty, CJ Morton, MW Parker Scientific reports 4 (1), 4765, 2014 | 139 | 2014 |
| The structure of the bacterial oxidoreductase enzyme DsbA in complex with a peptide reveals a basis for substrate specificity in the catalytic cycle of DsbA enzymes JJ Paxman, NA Borg, J Horne, PE Thompson, Y Chin, P Sharma, ... Journal of biological chemistry 284 (26), 17835-17845, 2009 | 86 | 2009 |
| Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification? J Wielens, SJ Headey, DI Rhodes, RJ Mulder, O Dolezal, JJ Deadman, ... Journal of Biomolecular Screening 18 (2), 147-159, 2013 | 85 | 2013 |
| A three-dimensional model of the human immunodeficiency virus type 1 integration complex J Wielens, IT Crosby, DK Chalmers Journal of computer-aided molecular design 19, 301-317, 2005 | 76 | 2005 |
| The interaction of lipophilic drugs with intestinal fatty acid-binding protein T Velkov, S Chuang, J Wielens, H Sakellaris, WN Charman, CJH Porter, ... Journal of Biological Chemistry 280 (18), 17769-17776, 2005 | 65 | 2005 |
| Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site J Wielens, SJ Headey, D Jeevarajah, DI Rhodes, J Deadman, ... FEBS letters 584 (8), 1455-1462, 2010 | 52 | 2010 |
| Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation A Quan, J Xue, J Wielens, KJ Smillie, V Anggono, MW Parker, MA Cousin, ... Proceedings of the National Academy of Sciences 109 (10), 3760-3765, 2012 | 34 | 2012 |
| Fragment‐Based Design of Ligands Targeting a Novel Site on the Integrase Enzyme of Human Immunodeficiency Virus 1 J Wielens, SJ Headey, JJ Deadman, DI Rhodes, MW Parker, ... ChemMedChem 6 (2), 258-261, 2011 | 34 | 2011 |
| Characterization of two distinct modes of drug binding to human intestinal fatty acid binding protein R Patil, A Laguerre, J Wielens, SJ Headey, ML Williams, MLR Hughes, ... ACS chemical biology 9 (11), 2526-2534, 2014 | 31 | 2014 |
| The binding of syndapin SH3 domain to dynamin proline-rich domain involves short and long distance elements L Luo, J Xue, A Kwan, R Gamsjaeger, J Wielens, L von Kleist, L Cubeddu, ... Journal of Biological Chemistry 291 (18), 9411-9424, 2016 | 30 | 2016 |
| Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis JP Vivian, J Scoullar, AL Robertson, SP Bottomley, J Horne, Y Chin, ... Journal of Biological Chemistry 283 (47), 32452-32461, 2008 | 30 | 2008 |
| Probing the fibrate binding specificity of rat liver fatty acid binding protein S Chuang, T Velkov, J Horne, J Wielens, DK Chalmers, CJH Porter, ... Journal of medicinal chemistry 52 (17), 5344-5355, 2009 | 21 | 2009 |
| Diuretic drug binding to human glutathione transferase P1‐1: potential role of Cys‐101 revealed in the double mutant C47S/Y108V I Quesada‐Soriano, LJ Parker, A Primavera, J Wielens, JK Holien, ... Journal of Molecular Recognition 24 (2), 220-234, 2011 | 15 | 2011 |
| Propargyloxyproline regio-and stereoisomers for click-conjugation of peptides: synthesis and application in linear and cyclic peptides SE Northfield, SJ Mountford, J Wielens, M Liu, L Zhang, H Herzog, ... Australian Journal of Chemistry 68 (9), 1365-1372, 2015 | 12 | 2015 |
| Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA. Sci Rep 4: 4765 DB Ascher, J Wielens, TL Nero, L Doughty, CJ Morton, MW Parker | 9 | 2014 |
| Cyclic Hexapeptide Mimics of the LEDGF Integrase Recognition Loop in Complex with HIV‐1 Integrase SE Northfield, J Wielens, SJ Headey, BJ Williams‐Noonan, M Mulcair, ... ChemMedChem 13 (15), 1555-1565, 2018 | 8 | 2018 |
| Preparation, crystallization and preliminary X-ray diffraction analysis of two intestinal fatty-acid binding proteins in the presence of 11-(dansylamino) undecanoic acid A Laguerre, J Wielens, MW Parker, CJH Porter, MJ Scanlon Acta Crystallographica Section F: Structural Biology and Crystallization …, 2011 | 8 | 2011 |
| NS5A-P32 deletion in hepatitis C genotype 1b infection is the most refractory treatment-mediated amino acid change exhibiting resistance to all NS5A inhibitors H Hikita, T Takehara Seminars in Liver Disease 40 (02), 143-153, 2020 | 7 | 2020 |
| 846 DISCOVERY OF A NEW SERIES OF POTENT, MULTI-GENOTYPE HCV NS5B INHIBITORS: IN VITRO ACTIVITY AND PRE-CLINICAL PHARMACOKINETIC RESULTS S Bond, J Cianci, A Draffan, A Luttick, M Frazetto, B Frey, R Halim, ... Journal of Hepatology, S330, 2012 | | 2012 |
