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ALEXANDER LEPAK
ALEXANDER LEPAK
Assistant Professor
Verified email at wisc.edu
Title
Cited by
Cited by
Year
In Vivo Comparison of the Pharmacodynamic Targets for Echinocandin Drugs against Candida Species
D Andes, DJ Diekema, MA Pfaller, J Bohrmuller, K Marchillo, A Lepak
Antimicrobial agents and chemotherapy 54 (6), 2497-2506, 2010
2482010
Time Course Global Gene Expression Analysis of an In Vivo Candida Biofilm
JE Nett, AJ Lepak, K Marchillo, DR Andes
The Journal of infectious diseases 200 (2), 307-313, 2009
2082009
Antifungal pharmacokinetics and pharmacodynamics
AJ Lepak, DR Andes
Cold Spring Harbor perspectives in medicine 5 (5), a019653, 2015
1352015
Animal models in the pharmacokinetic/pharmacodynamic evaluation of antimicrobial agents
M Zhao, AJ Lepak, DR Andes
Bioorganic & medicinal chemistry 24 (24), 6390-6400, 2016
1162016
Pharmacodynamic Target Evaluation of a Novel Oral Glucan Synthase Inhibitor, SCY-078 (MK-3118), Using an In Vivo Murine Invasive Candidiasis Model
AJ Lepak, K Marchillo, DR Andes
Antimicrobial Agents and Chemotherapy 59 (2), 1265-1272, 2015
962015
Impact of Antimicrobial Dosing Regimen on Evolution of Drug Resistance In Vivo: Fluconazole and Candida albicans
D Andes, A Forrest, A Lepak, J Nett, K Marchillo, L Lincoln
Antimicrobial agents and chemotherapy 50 (7), 2374-2383, 2006
942006
Pharmacodynamic optimization for treatment of invasive Candida auris infection
AJ Lepak, M Zhao, EL Berkow, SR Lockhart, DR Andes
Antimicrobial Agents and Chemotherapy 61 (8), 10.1128/aac. 00791-17, 2017
902017
Isavuconazole (BAL4815) pharmacodynamic target determination in an in vivo murine model of invasive pulmonary aspergillosis against wild-type and cyp51 mutant isolates of …
AJ Lepak, K Marchillo, J VanHecker, DR Andes
Antimicrobial agents and chemotherapy 57 (12), 6284-6289, 2013
892013
Fungal sepsis: optimizing antifungal therapy in the critical care setting
A Lepak, D Andes
Critical care clinics 27 (1), 123-147, 2011
892011
In Vivo Pharmacokinetics and Pharmacodynamics of ZTI-01 (Fosfomycin for Injection) in the Neutropenic Murine Thigh Infection Model against Escherichia coli …
AJ Lepak, M Zhao, B VanScoy, DS Taylor, E Ellis-Grosse, PG Ambrose, ...
Antimicrobial Agents and Chemotherapy 61 (6), 10.1128/aac. 00476-17, 2017
842017
Posaconazole Pharmacodynamic Target Determination against Wild-Type and Cyp51 Mutant Isolates of Aspergillus fumigatus in an In Vivo Model of Invasive …
AJ Lepak, K Marchillo, J VanHecker, DR Andes
Antimicrobial agents and chemotherapy 57 (1), 579-585, 2013
822013
In Vivo Pharmacokinetics and Pharmacodynamics of APX001 against Candida spp. in a Neutropenic Disseminated Candidiasis Mouse Model
M Zhao, AJ Lepak, B VanScoy, JC Bader, K Marchillo, J Vanhecker, ...
Antimicrobial agents and chemotherapy 62 (4), 10.1128/aac. 02542-17, 2018
762018
Pharmacodynamic evaluation of rezafungin (CD101) against Candida auris in the neutropenic mouse invasive candidiasis model
AJ Lepak, M Zhao, DR Andes
Antimicrobial agents and chemotherapy 62 (11), 10.1128/aac. 01572-18, 2018
642018
Isavuconazole Pharmacodynamic Target Determination for Candida Species in an In Vivo Murine Disseminated Candidiasis Model
AJ Lepak, K Marchillo, J VanHecker, D Diekema, DR Andes
Antimicrobial agents and chemotherapy 57 (11), 5642-5648, 2013
632013
Comparative pharmacodynamics of the new oxazolidinone tedizolid phosphate and linezolid in a neutropenic murine Staphylococcus aureus pneumonia model
AJ Lepak, K Marchillo, S Pichereau, WA Craig, DR Andes
Antimicrobial agents and chemotherapy 56 (11), 5916-5922, 2012
592012
A Simple Approach for Estimating Gene Expression in Candida albicans Directly from a Systemic Infection Site
D Andes, A Lepak, A Pitula, K Marchillo, J Clark
The Journal of infectious diseases 192 (5), 893-900, 2005
592005
Impact of MIC Range for Pseudomonas aeruginosa and Streptococcus pneumoniae on the Ceftolozane In Vivo Pharmacokinetic/Pharmacodynamic Target
AJ Lepak, A Reda, K Marchillo, J Van Hecker, WA Craig, D Andes
Antimicrobial Agents and Chemotherapy 58 (10), 6311-6314, 2014
572014
Time Course of Microbiologic Outcome and Gene Expression in Candida albicans during and following In Vitro and In Vivo Exposure to Fluconazole
A Lepak, J Nett, L Lincoln, K Marchillo, D Andes
Antimicrobial agents and chemotherapy 50 (4), 1311-1319, 2006
572006
Pharmacodynamics of a long-acting echinocandin, CD101, in a neutropenic invasive-candidiasis murine model using an extended-interval dosing design
AJ Lepak, M Zhao, B VanScoy, PG Ambrose, DR Andes
Antimicrobial Agents and Chemotherapy 62 (2), 10.1128/aac. 02154-17, 2018
532018
In Vivo Pharmacodynamic Target Assessment of Delafloxacin against Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumoniae in a Murine …
AJ Lepak, DR Andes
Antimicrobial Agents and Chemotherapy 60 (8), 4764-4769, 2016
532016
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