Rebecca Coll
Rebecca Coll
The Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast
Verified email at qub.ac.uk - Homepage
TitleCited byYear
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
SL Masters, A Dunne, SL Subramanian, RL Hull, GM Tannahill, FA Sharp, ...
Nature immunology 11 (10), 897, 2010
8972010
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
RC Coll, AAB Robertson, JJ Chae, SC Higgins, R Muñoz-Planillo, ...
Nature medicine 21 (3), 248, 2015
7162015
T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells
G Arbore, EE West, R Spolski, AAB Robertson, A Klos, C Rheinheimer, ...
Science 352 (6292), aad1210, 2016
1682016
Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments
M Haneklaus, LAJ O’Neill, RC Coll
Current opinion in immunology 25 (1), 40-45, 2013
1362013
New insights into the regulation of signalling by toll-like receptors and nod-like receptors
RC Coll, LAJ O’Neill
Journal of innate immunity 2 (5), 406-421, 2010
1362010
Monounsaturated fatty acid–enriched high-fat diets impede adipose NLRP3 inflammasome–mediated IL-1β secretion and insulin resistance despite obesity
OM Finucane, CL Lyons, AM Murphy, CM Reynolds, R Klinger, NP Healy, ...
Diabetes 64 (6), 2116-2128, 2015
1242015
The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes
RC Coll, LAJ O'Neill
PloS one 6 (12), e29539, 2011
1052011
The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype
AA Basiorka, KL McGraw, EA Eksioglu, X Chen, J Johnson, L Zhang, ...
Blood 128 (25), 2960-2975, 2016
652016
Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction
CJ Greenhill, GW Jones, MA Nowell, Z Newton, AK Harvey, AN Moideen, ...
Arthritis research & therapy 16 (4), 419, 2014
492014
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity
D Boucher, M Monteleone, RC Coll, KW Chen, CM Ross, JL Teo, ...
Journal of Experimental Medicine 215 (3), 827-840, 2018
442018
Glutathione transferase omega 1 is required for the lipopolysaccharide-stimulated induction of NADPH oxidase 1 and the production of reactive oxygen species in macrophages
D Menon, R Coll, PG Board
Free Radical Biology and Medicine 73, 318-327, 2014
372014
GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway
D Menon, R Coll, LAJ O'Neill, PG Board
J Cell Sci 128 (10), 1982-1990, 2015
232015
The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome
R Domingo-Fernández, RC Coll, J Kearney, S Breit, LAJ O'Neill
Journal of Biological Chemistry 292 (29), 12077-12087, 2017
222017
Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals
JS Bezbradica, RC Coll, K Schroder
Cellular & molecular immunology 14 (1), 118, 2017
202017
Questions and controversies in innate immune research: what is the physiological role of NLRP3?
RC Coll, LAJ O’Neill, K Schroder
Cell death discovery 2, 16019, 2016
202016
Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling
MM Hughes, P Lavrencic, RC Coll, T Ve, DG Ryan, NC Williams, ...
Proceedings of the National Academy of Sciences 114 (32), E6480-E6489, 2017
122017
Sulfonylureas as concomitant insulin secretagogues and NLRP3 inflammasome inhibitors
JR Hill, RC Coll, N Sue, JC Reid, J Dou, CL Holley, R Pelingon, ...
ChemMedChem 12 (17), 1449-1457, 2017
112017
Evidence against a role for NLRP3-driven islet inflammation in db/db mice
HL Kammoun, TL Allen, DC Henstridge, S Barre, RC Coll, GI Lancaster, ...
Molecular metabolism 10, 66-73, 2018
92018
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
RC Coll, JR Hill, CJ Day, A Zamoshnikova, D Boucher, NL Massey, ...
Nature chemical biology, 1, 2019
32019
Autocrine NLRP3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-gamma in CD4+ T cells
G Arbore, E West, A Robertson, A Klos, C Rheinheimer, P Dutow, ...
International Congress of Immunology (ICI), 2016
32016
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