| Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis T Maekawa, JL Krauss, T Abe, R Jotwani, M Triantafilou, K Triantafilou, ... Cell host & microbe 15 (6), 768-778, 2014 | 409 | 2014 |
| Periodontitis‐associated up‐regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease T Nakajima, T Honda, H Domon, T Okui, K Kajita, H Ito, N Takahashi, ... Journal of periodontal research 45 (1), 116-122, 2010 | 236 | 2010 |
| Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile T Maekawa, N Takahashi, K Tabeta, Y Aoki, H Miyashita, S Miyauchi, ... PloS one 6 (5), e20240, 2011 | 166 | 2011 |
| Topical treatment with probiotic Lactobacillus brevis CD2 inhibits experimental periodontal inflammation and bone loss T Maekawa, G Hajishengallis Journal of periodontal research 49 (6), 785-791, 2014 | 144 | 2014 |
| Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis T Maekawa, T Abe, E Hajishengallis, KB Hosur, RA DeAngelis, D Ricklin, ... The Journal of Immunology 192 (12), 6020-6027, 2014 | 119 | 2014 |
| Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway T Maekawa, K Hosur, T Abe, A Kantarci, A Ziogas, B Wang, TE Van Dyke, ... Nature communications 6 (1), 8272, 2015 | 110 | 2015 |
| Role of complement in host–microbe homeostasis of the periodontium G Hajishengallis, T Abe, T Maekawa, E Hajishengallis, JD Lambris Seminars in immunology 25 (1), 65-72, 2013 | 103 | 2013 |
| Elevated expression of IL-17 and IL-12 genes in chronic inflammatory periodontal disease T Honda, Y Aoki, N Takahashi, T Maekawa, T Nakajima, H Ito, K Tabeta, ... Clinica Chimica Acta 395 (1-2), 137-141, 2008 | 101 | 2008 |
| DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates J Shin, T Maekawa, T Abe, E Hajishengallis, K Hosur, K Pyaram, ... Science translational medicine 7 (307), 307ra155-307ra155, 2015 | 98 | 2015 |
| Donor cell leukemia arising from preleukemic clones with a novel germline DDX41 mutation after allogenic hematopoietic stem cell transplantation S Kobayashi, A Kobayashi, Y Osawa, S Nagao, K Takano, Y Okada, ... Leukemia 31 (4), 1020-1022, 2017 | 95 | 2017 |
| Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche I Mitroulis, LS Chen, RP Singh, I Kourtzelis, M Economopoulou, ... The Journal of clinical investigation 127 (10), 3624-3639, 2017 | 88 | 2017 |
| Complement-dependent mechanisms and interventions in periodontal disease G Hajishengallis, T Kajikawa, E Hajishengallis, T Maekawa, ES Reis, ... Frontiers in immunology 10, 440534, 2019 | 80 | 2019 |
| Complement involvement in periodontitis: molecular mechanisms and rational therapeutic approaches G Hajishengallis, T Maekawa, T Abe, E Hajishengallis, JD Lambris Immune Responses to Biosurfaces: Mechanisms and Therapeutic Interventions, 57-74, 2015 | 80 | 2015 |
| The B cell–stimulatory cytokines BLyS and APRIL are elevated in human periodontitis and are required for B cell–dependent bone loss in experimental murine periodontitis T Abe, M AlSarhan, MR Benakanakere, T Maekawa, DF Kinane, ... The Journal of Immunology 195 (4), 1427-1435, 2015 | 79 | 2015 |
| Inhibition of pre‐existing natural periodontitis in non‐human primates by a locally administered peptide inhibitor of complement C3 T Maekawa, RA Briones, RRG Resuello, JV Tuplano, E Hajishengallis, ... Journal of clinical periodontology 43 (3), 238-249, 2016 | 68 | 2016 |
| Neutrophil elastase subverts the immune response by cleaving toll-like receptors and cytokines in pneumococcal pneumonia H Domon, K Nagai, T Maekawa, M Oda, D Yonezawa, W Takeda, ... Frontiers in immunology 9, 345207, 2018 | 67 | 2018 |
| A bacterial metabolite ameliorates periodontal pathogen-induced gingival epithelial barrier disruption via GPR40 signaling M Yamada, N Takahashi, Y Matsuda, K Sato, M Yokoji, B Sulijaya, ... Scientific reports 8 (1), 9008, 2018 | 66 | 2018 |
| Streptococcus pneumoniae disrupts pulmonary immune defence via elastase release following pneumolysin-dependent neutrophil lysis H Domon, M Oda, T Maekawa, K Nagai, W Takeda, Y Terao Scientific reports 6 (1), 38013, 2016 | 58 | 2016 |
| A large-scale, prospective, observational study of leukocytapheresis for ulcerative colitis: treatment outcomes of 847 patients in clinical practice Y Yokoyama, K Matsuoka, T Kobayashi, K Sawada, T Fujiyoshi, T Ando, ... Journal of Crohn's and Colitis 8 (9), 981-991, 2014 | 56 | 2014 |
| Differential expression and roles of secreted frizzled-related protein 5 and the wingless homolog Wnt5a in periodontitis T Maekawa, P Kulwattanaporn, K Hosur, H Domon, M Oda, Y Terao, ... Journal of Dental Research 96 (5), 571-577, 2017 | 46 | 2017 |
George HajishengallisThomas W. Evans Centennial Professor, University of PennsylvaniaVerified email at upenn.edu
