Hywel Williams
Hywel Williams
CSL Limited
Verified email at csl.com.au - Homepage
Title
Cited by
Cited by
Year
Strategies to address low drug solubility in discovery and development
HD Williams, NL Trevaskis, SA Charman, RM Shanker, WN Charman, ...
Pharmacological reviews 65 (1), 315-499, 2013
10342013
Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: method parameterization and comparison of in vitro digestion profiles across a …
HD Williams, P Sassene, K Kleberg, JC Bakala-N'Goma, M Calderone, ...
Journal of pharmaceutical sciences 101 (9), 3360-3380, 2012
1872012
50 years of oral lipid-based formulations: provenance, progress and future perspectives
OM Feeney, MF Crum, CL McEvoy, NL Trevaskis, HD Williams, ...
Advanced drug delivery reviews 101, 167-194, 2016
1862016
Lipid digestion as a trigger for supersaturation: evaluation of the impact of supersaturation stabilization on the in vitro and in vivo performance of self-emulsifying drug …
MU Anby, HD Williams, M McIntosh, H Benameur, GA Edwards, ...
Molecular pharmaceutics 9 (7), 2063-2079, 2012
1052012
Toward the Establishment of Standardized in Vitro Tests for Lipid-Based Formulations. 2. The Effect of Bile Salt Concentration and Drug Loading on the Performance of Type I …
HD Williams, MU Anby, P Sassene, K Kleberg, JC Bakala-N’Goma, ...
Molecular pharmaceutics 9 (11), 3286-3300, 2012
1042012
Toward the establishment of standardized in vitro tests for lipid-based formulations, part 3: understanding supersaturation versus precipitation potential during the in vitro …
HD Williams, P Sassene, K Kleberg, M Calderone, A Igonin, E Jule, ...
Pharmaceutical research 30 (12), 3059-3076, 2013
862013
In vitro digestion testing of lipid-based delivery systems: calcium ions combine with fatty acids liberated from triglyceride rich lipid solutions to form soaps and reduce the …
R Devraj, HD Williams, DB Warren, A Mullertz, CJH Porter, CW Pouton
International journal of pharmaceutics 441 (1-2), 323-333, 2013
852013
Transformation of poorly water-soluble drugs into lipophilic ionic liquids enhances oral drug exposure from lipid based formulations
Y Sahbaz, HD Williams, TH Nguyen, J Saunders, L Ford, SA Charman, ...
Molecular pharmaceutics 12 (6), 1980-1991, 2015
832015
Lipid-based formulations and drug supersaturation: harnessing the unique benefits of the lipid digestion/absorption pathway
HD Williams, NL Trevaskis, YY Yeap, MU Anby, CW Pouton, CJH Porter
Pharmaceutical research 30 (12), 2976-2992, 2013
832013
Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility
HD Williams, Y Sahbaz, L Ford, TH Nguyen, PJ Scammells, CJH Porter
Chemical Communications 50 (14), 1688-1690, 2014
802014
Incomplete Desorption of Liquid Excipients Reduces the in Vitro and in Vivo Performance of Self-Emulsifying Drug Delivery Systems Solidified by Adsorption onto …
M Van Speybroeck, HD Williams, TH Nguyen, MU Anby, CJH Porter, ...
Molecular pharmaceutics 9 (9), 2750-2760, 2012
732012
The extended release properties of HPMC matrices in the presence of dietary sugars
HD Williams, R Ward, IJ Hardy, CD Melia
Journal of controlled release 138 (3), 251-259, 2009
522009
‘Stealth’lipid-based formulations: Poly (ethylene glycol)-mediated digestion inhibition improves oral bioavailability of a model poorly water soluble drug
OM Feeney, HD Williams, CW Pouton, CJH Porter
Journal of Controlled Release 192, 219-227, 2014
512014
Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase
JC Bakala-N’Goma, HD Williams, PJ Sassene, K Kleberg, M Calderone, ...
Pharmaceutical Research 32 (4), 1279-1287, 2015
502015
Toward the establishment of standardized in vitro tests for lipid-based formulations, part 6: effects of varying pancreatin and calcium levels
P Sassene, K Kleberg, HD Williams, JC Bakala-N’Goma, F Carričre, ...
The AAPS journal 16 (6), 1344-1357, 2014
442014
Lipid-based formulations solidified via adsorption onto the mesoporous carrier NeusilinŽ US2: Effect of drug type and formulation composition on in vitro pharmaceutical performance
HD Williams, M Van Speybroeck, P Augustijns, CJH Porter
Journal of pharmaceutical sciences 103 (6), 1734-1746, 2014
432014
A new in vitro lipid digestion–in vivo absorption model to evaluate the mechanisms of drug absorption from lipid-based formulations
MF Crum, NL Trevaskis, HD Williams, CW Pouton, CJH Porter
Pharmaceutical research 33 (4), 970-982, 2016
422016
Drug release from HPMC matrices in milk and fat‐rich emulsions
HD Williams, KP Nott, DA Barrett, R Ward, IJ Hardy, CD Melia
Journal of pharmaceutical sciences 100 (11), 4823-4835, 2011
382011
Digestion of phospholipids after secretion of bile into the duodenum changes the phase behavior of bile components
WA Birru, DB Warren, A Ibrahim, HD Williams, H Benameur, CJH Porter, ...
Molecular pharmaceutics 11 (8), 2825-2834, 2014
342014
The effect of sucrose and salts in combination on the drug release behaviour of an HPMC matrix
HD Williams, R Ward, IJ Hardy, CD Melia
European journal of pharmaceutics and biopharmaceutics 76 (3), 433-436, 2010
332010
The system can't perform the operation now. Try again later.
Articles 1–20