|Strategies to address low drug solubility in discovery and development|
HD Williams, NL Trevaskis, SA Charman, RM Shanker, WN Charman, ...
Pharmacological reviews 65 (1), 315-499, 2013
|Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: method parameterization and comparison of in vitro digestion profiles across a …|
HD Williams, P Sassene, K Kleberg, JC Bakala-N'Goma, M Calderone, ...
Journal of pharmaceutical sciences 101 (9), 3360-3380, 2012
|50 years of oral lipid-based formulations: provenance, progress and future perspectives|
OM Feeney, MF Crum, CL McEvoy, NL Trevaskis, HD Williams, ...
Advanced drug delivery reviews 101, 167-194, 2016
|Lipid digestion as a trigger for supersaturation: evaluation of the impact of supersaturation stabilization on the in vitro and in vivo performance of self-emulsifying drug …|
MU Anby, HD Williams, M McIntosh, H Benameur, GA Edwards, ...
Molecular pharmaceutics 9 (7), 2063-2079, 2012
|Toward the Establishment of Standardized in Vitro Tests for Lipid-Based Formulations. 2. The Effect of Bile Salt Concentration and Drug Loading on the Performance of Type I …|
HD Williams, MU Anby, P Sassene, K Kleberg, JC Bakala-N’Goma, ...
Molecular pharmaceutics 9 (11), 3286-3300, 2012
|Toward the establishment of standardized in vitro tests for lipid-based formulations, part 3: understanding supersaturation versus precipitation potential during the in vitro …|
HD Williams, P Sassene, K Kleberg, M Calderone, A Igonin, E Jule, ...
Pharmaceutical research 30 (12), 3059-3076, 2013
|In vitro digestion testing of lipid-based delivery systems: calcium ions combine with fatty acids liberated from triglyceride rich lipid solutions to form soaps and reduce the …|
R Devraj, HD Williams, DB Warren, A Mullertz, CJH Porter, CW Pouton
International journal of pharmaceutics 441 (1-2), 323-333, 2013
|Transformation of poorly water-soluble drugs into lipophilic ionic liquids enhances oral drug exposure from lipid based formulations|
Y Sahbaz, HD Williams, TH Nguyen, J Saunders, L Ford, SA Charman, ...
Molecular pharmaceutics 12 (6), 1980-1991, 2015
|Lipid-based formulations and drug supersaturation: harnessing the unique benefits of the lipid digestion/absorption pathway|
HD Williams, NL Trevaskis, YY Yeap, MU Anby, CW Pouton, CJH Porter
Pharmaceutical research 30 (12), 2976-2992, 2013
|Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility|
HD Williams, Y Sahbaz, L Ford, TH Nguyen, PJ Scammells, CJH Porter
Chemical Communications 50 (14), 1688-1690, 2014
|Incomplete Desorption of Liquid Excipients Reduces the in Vitro and in Vivo Performance of Self-Emulsifying Drug Delivery Systems Solidified by Adsorption onto …|
M Van Speybroeck, HD Williams, TH Nguyen, MU Anby, CJH Porter, ...
Molecular pharmaceutics 9 (9), 2750-2760, 2012
|The extended release properties of HPMC matrices in the presence of dietary sugars|
HD Williams, R Ward, IJ Hardy, CD Melia
Journal of controlled release 138 (3), 251-259, 2009
|‘Stealth’lipid-based formulations: Poly (ethylene glycol)-mediated digestion inhibition improves oral bioavailability of a model poorly water soluble drug|
OM Feeney, HD Williams, CW Pouton, CJH Porter
Journal of Controlled Release 192, 219-227, 2014
|Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase|
JC Bakala-N’Goma, HD Williams, PJ Sassene, K Kleberg, M Calderone, ...
Pharmaceutical Research 32 (4), 1279-1287, 2015
|Toward the establishment of standardized in vitro tests for lipid-based formulations, part 6: effects of varying pancreatin and calcium levels|
P Sassene, K Kleberg, HD Williams, JC Bakala-N’Goma, F Carričre, ...
The AAPS journal 16 (6), 1344-1357, 2014
|Lipid-based formulations solidified via adsorption onto the mesoporous carrier NeusilinŽ US2: Effect of drug type and formulation composition on in vitro pharmaceutical performance|
HD Williams, M Van Speybroeck, P Augustijns, CJH Porter
Journal of pharmaceutical sciences 103 (6), 1734-1746, 2014
|A new in vitro lipid digestion–in vivo absorption model to evaluate the mechanisms of drug absorption from lipid-based formulations|
MF Crum, NL Trevaskis, HD Williams, CW Pouton, CJH Porter
Pharmaceutical research 33 (4), 970-982, 2016
|Drug release from HPMC matrices in milk and fat‐rich emulsions|
HD Williams, KP Nott, DA Barrett, R Ward, IJ Hardy, CD Melia
Journal of pharmaceutical sciences 100 (11), 4823-4835, 2011
|Digestion of phospholipids after secretion of bile into the duodenum changes the phase behavior of bile components|
WA Birru, DB Warren, A Ibrahim, HD Williams, H Benameur, CJH Porter, ...
Molecular pharmaceutics 11 (8), 2825-2834, 2014
|The effect of sucrose and salts in combination on the drug release behaviour of an HPMC matrix|
HD Williams, R Ward, IJ Hardy, CD Melia
European journal of pharmaceutics and biopharmaceutics 76 (3), 433-436, 2010