| The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice TM Lieu, G Jayaweera, P Zhao, DP Poole, D Jensen, M Grace, P McIntyre, ... Gastroenterology 147 (6), 1417-1428, 2014 | 225 | 2014 |
| Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief DD Jensen, TM Lieu, ML Halls, NA Veldhuis, WL Imlach, QN Mai, ... Science Translational Medicine 9 (392), eaal3447, 2017 | 191 | 2017 |
| Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4 P Zhao, TM Lieu, N Barlow, M Metcalf, NA Veldhuis, DD Jensen, M Kocan, ... Journal of Biological Chemistry 289 (39), 27215-27234, 2014 | 182 | 2014 |
| Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission RE Yarwood, WL Imlach, TM Lieu, NA Veldhuis, DD Jensen, ... Proceedings of the National Academy of Sciences 114 (46), 12309-12314, 2017 | 152 | 2017 |
| Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome NN Jimenez-Vargas, LA Pattison, P Zhao, TM Lieu, R Latorre, DD Jensen, ... Proceedings of the National Academy of Sciences 115 (31), E7438-E7447, 2018 | 149 | 2018 |
| Effects of serotonin and slow-release 5-hydroxytryptophan on gastrointestinal motility in a mouse model of depression N Israelyan, A Del Colle, Z Li, Y Park, A Xing, JPR Jacobsen, RA Luna, ... Gastroenterology 157 (2), 507-521. e4, 2019 | 144 | 2019 |
| Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum S Abu‐Hayyeh, C Ovadia, TM Lieu, DD Jensen, J Chambers, PH Dixon, ... Hepatology 63 (4), 1287-1298, 2016 | 144 | 2016 |
| A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain PD Ramírez-García, JS Retamal, P Shenoy, W Imlach, M Sykes, N Truong, ... Nature Nanotechnology 14 (12), 1150-1159, 2019 | 113 | 2019 |
| Therapeutic targeting of endosomal G-protein-coupled receptors ARB Thomsen, DD Jensen, GA Hicks, NW Bunnett Trends in pharmacological sciences 39 (10), 879-891, 2018 | 105 | 2018 |
| The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts DD Jensen, CB Godfrey, C Niklas, M Canals, M Kocan, DP Poole, ... Journal of Biological Chemistry 288 (32), 22942-22960, 2013 | 87 | 2013 |
| Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain NN Jimenez-Vargas, J Gong, MJ Wisdom, DD Jensen, R Latorre, ... Proceedings of the National Academy of Sciences 117 (26), 15281-15292, 2020 | 82 | 2020 |
| Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice F De Logu, R Nassini, A Hegron, L Landini, DD Jensen, R Latorre, J Ding, ... Nature communications 13 (1), 646, 2022 | 73 | 2022 |
| The critical role of the central nervous system (pro) renin receptor in regulating systemic blood pressure Q Xu, DD Jensen, H Peng, Y Feng Pharmacology & therapeutics 164, 126-134, 2016 | 68 | 2016 |
| Legumain induces oral cancer pain by biased agonism of protease-activated receptor-2 NH Tu, DD Jensen, BM Anderson, E Chen, NN Jimenez-Vargas, ... Journal of Neuroscience 41 (1), 193-210, 2021 | 36 | 2021 |
| Agonist that activates the µ-opioid receptor in acidified microenvironments inhibits colitis pain without side effects NN Jiménez-Vargas, Y Yu, DD Jensen, DD Bok, M Wisdom, R Latorre, ... Gut 71 (4), 695-704, 2022 | 32 | 2022 |
| The gonadotropin-releasing hormone type I receptor is expressed in the mouse cerebellum AJ Albertson, H Talbott, Q Wang, D Jensen, DC Skinner The Cerebellum 7, 379-384, 2008 | 32 | 2008 |
| Endothelin-converting enzyme 1 and β-arrestins exert spatiotemporal control of substance P-induced inflammatory signals DD Jensen, ML Halls, JE Murphy, M Canals, F Cattaruzza, DP Poole, ... Journal of Biological Chemistry 289 (29), 20283-20294, 2014 | 29 | 2014 |
| Protein kinase D and Gβγ subunits mediate agonist-evoked translocation of protease-activated receptor-2 from the Golgi apparatus to the plasma membrane DD Jensen, P Zhao, NN Jimenez-Vargas, TM Lieu, M Gerges, ... Journal of Biological Chemistry 291 (21), 11285-11299, 2016 | 26 | 2016 |
| Trafficking of tachykinin neurokinin 3 receptor to nuclei of neurons in the paraventricular nucleus of the hypothalamus following osmotic challenge D Jensen, Z Zhang, FW Flynn Neuroscience 155 (1), 308-316, 2008 | 23 | 2008 |
| Cathepsin S Evokes PAR2-Dependent Pain in Oral Squamous Cell Carcinoma Patients and Preclinical Mouse Models NH Tu, K Inoue, E Chen, BM Anderson, CM Sawicki, NN Scheff, HD Tran, ... Cancers 13 (18), 4697, 2021 | 21 | 2021 |
TinaMarie LieuMedical Director, Sage TherapeuticsVerified email at sagerx.com
