| Phase separation of a PKA regulatory subunit controls cAMP compartmentation and oncogenic signaling JZ Zhang, TW Lu, LM Stolerman, B Tenner, JR Yang, JF Zhang, M Falcke, ... Cell 182 (6), 1531-1544. e15, 2020 | 199 | 2020 |
| The in situ structure of Parkinson’s disease-linked LRRK2 R Watanabe, R Buschauer, J Böhning, M Audagnotto, K Lasker, TW Lu, ... Cell 182 (6), 1508-1518. e16, 2020 | 174 | 2020 |
| Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling VA Bachmann, JE Mayrhofer, R Ilouz, P Tschaikner, P Raffeiner, R Röck, ... Proceedings of the National Academy of Sciences 113 (28), 7786-7791, 2016 | 104 | 2016 |
| Acid/Base‐and Anion‐Controllable Organogels Formed From a Urea‐Based Molecular Switch SY Hsueh, CT Kuo, TW Lu, CC Lai, YH Liu, HF Hsu, SM Peng, C Chen, ... Angewandte Chemie International Edition 49 (48), 9170-9173, 2010 | 103 | 2010 |
| From structure to the dynamic regulation of a molecular switch: A journey over 3 decades SS Taylor, J Wu, JGH Bruystens, JC Del Rio, TW Lu, AP Kornev, ... Journal of Biological Chemistry 296, 2021 | 55 | 2021 |
| Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP TW Lu, J Wu, PC Aoto, JH Weng, LG Ahuja, N Sun, CY Cheng, P Zhang, ... Proceedings of the National Academy of Sciences 116 (33), 16347-16356, 2019 | 33 | 2019 |
| Structures of the PKA RIα holoenzyme with the FLHCC driver J-PKAcα or wild-type PKAcα B Cao, TW Lu, JAM Fiesco, M Tomasini, L Fan, SM Simon, SS Taylor, ... Structure 27 (5), 816-828. e4, 2019 | 32 | 2019 |
| Molecular switch based on very weak association between BPX26C6 and two recognition units TW Lu, CF Chang, CC Lai, SH Chiu Organic letters 15 (22), 5742-5745, 2013 | 26 | 2013 |
| Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in … TW Lu, PC Aoto, JH Weng, C Nielsen, JN Cash, J Hall, P Zhang, ... PLoS Biology 18 (12), e3001018, 2020 | 24 | 2020 |
| PKA RIα phase separation drives cAMP compartmentation and suppresses tumorigenic signaling JZ Zhang, TW Lu, B Tenner, J Yang, JF Zhang, S Taylor, S Mehta, ... The FASEB Journal 34 (S1), 1-1, 2020 | 2 | 2020 |
| The in Situ structure of a Parkinson's Disease Mutant LRRK2 Bound to Cellular Microtubules Revealed by Cryo-electron Tomography R Watanabe, R Buschauer, J Böhning, M Audagnotto, K Lasker, TW Lu, ... Microscopy and Microanalysis 26 (S2), 800-802, 2020 | | 2020 |
| Functional and Structural Characterization of Acrodysostosis Mutations of PKA RIα Reveals Mechanism Causing resistant to cAMP activation J Del-rio, L Wu, T Lu, P Aoto, SS Taylor The FASEB Journal 34 (S1), 1-1, 2020 | | 2020 |
| PKA RIα Holoenzyme Structure Reveals ATP‐Dependent Dynamics and Allosteric Regulation in Isoform‐Specific Manner TW Lu, J Wu, P Aoto, JH Weng, LG Ahuja, N Sun, S Taylor The FASEB Journal 34 (S1), 1-1, 2020 | | 2020 |
| Two PKA RIA Holoenzyme Structural States Define ATP as an Isoform Specific Orthosteric Inhibitor that Competes with Allosteric Activator, ATP TW Lu, SS Taylor Biophysical Journal 118 (3), 354a, 2020 | | 2020 |
| Isoform-specific PKA holoenzymes differ in structure, function and allosteric regulation T Lu University of California, San Diego, 2020 | | 2020 |
| Designing an allosteric switch: lessons learned from PKA SS Taylor, J del Rio, K Haushalter, TW Lu JOURNAL OF TRANSLATIONAL MEDICINE 17 (1), 2019 | | 2019 |
