| Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer A Carracedo, L Ma, J Teruya-Feldstein, F Rojo, L Salmena, A Alimonti, ... The Journal of clinical investigation 118 (9), 3065-3074, 2008 | 1560 | 2008 |
| Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast CancerCombination of PI3K-and PARP-Inhibitors to Treat Breast Cancer A Juvekar, LN Burga, H Hu, EP Lunsford, YH Ibrahim, J Balmañà, ... Cancer discovery 2 (11), 1048-1063, 2012 | 404 | 2012 |
| Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus P Liu, M Begley, W Michowski, H Inuzuka, M Ginzberg, D Gao, P Tsou, ... Nature 508 (7497), 541-545, 2014 | 326 | 2014 |
| Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function A Papa, L Wan, M Bonora, L Salmena, MS Song, RM Hobbs, A Lunardi, ... Cell 157 (3), 595-610, 2014 | 258 | 2014 |
| Functional antagonism between Sall4 and Plzf defines germline progenitors RM Hobbs, S Fagoonee, A Papa, K Webster, F Altruda, R Nishinakamura, ... Cell stem cell 10 (3), 284-298, 2012 | 168 | 2012 |
| Regulation of apoptosis by PML and the PML-NBs R Bernardi, A Papa, PP Pandolfi Oncogene 27 (48), 6299-6312, 2008 | 165 | 2008 |
| Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway YR Lee, M Chen, JD Lee, J Zhang, SY Lin, TM Fu, H Chen, T Ishikawa, ... Science 364 (6441), eaau0159, 2019 | 145 | 2019 |
| The PTEN–PI3K axis in cancer A Papa, PP Pandolfi Biomolecules 9 (4), 153, 2019 | 124 | 2019 |
| A SP1/MIZ1/MYCN Repression Complex Recruits HDAC1 at the TRKA and p75NTR Promoters and Affects Neuroblastoma Malignancy by Inhibiting the Cell Response to NGFMYCN Represses … N Iraci, D Diolaiti, A Papa, A Porro, E Valli, S Gherardi, S Herold, M Eilers, ... Cancer research 71 (2), 404-412, 2011 | 95 | 2011 |
| The inositol polyphosphate 5-phosphatase PIPP regulates AKT1-dependent breast cancer growth and metastasis LM Ooms, LC Binge, EM Davies, P Rahman, JRW Conway, R Gurung, ... Cancer cell 28 (2), 155-169, 2015 | 93 | 2015 |
| In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K–AKT Signaling at EndosomesINPP4B Inhibits Thyroid Tumorigenesis and Metastasis C Li Chew, A Lunardi, F Gulluni, DT Ruan, M Chen, L Salmena, ... Cancer discovery 5 (7), 740-751, 2015 | 90 | 2015 |
| Intragenic antagonistic roles of protein and circRNA in tumorigenesis J Guarnerio, Y Zhang, G Cheloni, R Panella, J Mae Katon, M Simpson, ... Cell research 29 (8), 628-640, 2019 | 87 | 2019 |
| Vulnerabilities of PTEN–TP53-Deficient Prostate Cancers to Compound PARP–PI3K InhibitionPI3K and PARP Inhibition in PTEN-Deficient Prostate Cancer E González-Billalabeitia, N Seitzer, SJ Song, MS Song, A Patnaik, XS Liu, ... Cancer discovery 4 (8), 896-904, 2014 | 84 | 2014 |
| Role of aberrant PI3K pathway activation in gallbladder tumorigenesis A Lunardi, KA Webster, A Papa, B Padmani, JG Clohessy, RT Bronson, ... Oncotarget 5 (4), 894, 2014 | 49 | 2014 |
| Functional cooperation between TrkA and p75NTR accelerates neuronal differentiation by increased transcription of GAP-43 and p21 (CIP/WAF) genes via ERK1/2 and AP-1 activities D Diolaiti, R Bernardoni, S Trazzi, A Papa, A Porro, F Bono, JM Herbert, ... Experimental cell research 313 (14), 2980-2992, 2007 | 48 | 2007 |
| The PTEN tumor suppressor forms homodimers in solution F Heinrich, S Chakravarthy, H Nanda, A Papa, PP Pandolfi, AH Ross, ... Structure 23 (10), 1952-1957, 2015 | 32 | 2015 |
| GILZ-dependent modulation of mTORC1 regulates spermatogonial maintenance HM La, AL Chan, JMD Legrand, FJ Rossello, CG Gangemi, A Papa, ... Development 145 (18), dev165324, 2018 | 23 | 2018 |
| Pml represses tumour progression through inhibition of mTOR R Bernardi, A Papa, A Egia, N Coltella, J Teruya‐Feldstein, S Signoretti, ... EMBO molecular medicine 3 (5), 249-257, 2011 | 18 | 2011 |
| PTEN and Other PtdIns(3,4,5)P3 Lipid Phosphatases in Breast Cancer MP Csolle, LM Ooms, A Papa, CA Mitchell International Journal of Molecular Sciences 21 (23), 9189, 2020 | 16 | 2020 |
| Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity RH Newton, Y Lu, A Papa, GH Whitcher, YJ Kang, C Yan, PP Pandolfi, ... Blood, The Journal of the American Society of Hematology 125 (5), 852-855, 2015 | 15 | 2015 |
Pier Paolo PandolfiDirector, Cancer Center and Cancer Research Institute, Beth Israel Deaconess Medical CenterVerified email at bidmc.harvard.edu
