| Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer A Carracedo, L Ma, J Teruya-Feldstein, F Rojo, L Salmena, A Alimonti, ... The Journal of clinical investigation 118 (9), 3065-3074, 2008 | 1683 | 2008 |
| Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer A Juvekar, LN Burga, H Hu, EP Lunsford, YH Ibrahim, J Balmañà, ... Cancer discovery 2 (11), 1048-1063, 2012 | 472 | 2012 |
| Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus P Liu, M Begley, W Michowski, H Inuzuka, M Ginzberg, D Gao, P Tsou, ... Nature 508 (7497), 541-545, 2014 | 397 | 2014 |
| Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function A Papa, L Wan, M Bonora, L Salmena, MS Song, RM Hobbs, A Lunardi, ... Cell 157 (3), 595-610, 2014 | 319 | 2014 |
| Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway YR Lee, M Chen, JD Lee, J Zhang, SY Lin, TM Fu, H Chen, T Ishikawa, ... Science 364 (6441), eaau0159, 2019 | 261 | 2019 |
| The PTEN–PI3K axis in cancer A Papa, PP Pandolfi Biomolecules 9 (4), 153, 2019 | 258 | 2019 |
| Functional antagonism between Sall4 and Plzf defines germline progenitors RM Hobbs, S Fagoonee, A Papa, K Webster, F Altruda, R Nishinakamura, ... Cell stem cell 10 (3), 284-298, 2012 | 201 | 2012 |
| Regulation of apoptosis by PML and the PML-NBs R Bernardi, A Papa, PP Pandolfi Oncogene 27 (48), 6299-6312, 2008 | 198 | 2008 |
| Signaling pathways in cancer: therapeutic targets, combinatorial treatments, and new developments HYK Yip, A Papa Cells 10 (3), 659, 2021 | 153 | 2021 |
| Intragenic antagonistic roles of protein and circRNA in tumorigenesis J Guarnerio, Y Zhang, G Cheloni, R Panella, J Mae Katon, M Simpson, ... Cell research 29 (8), 628-640, 2019 | 143 | 2019 |
| The inositol polyphosphate 5-phosphatase PIPP regulates AKT1-dependent breast cancer growth and metastasis LM Ooms, LC Binge, EM Davies, P Rahman, JRW Conway, R Gurung, ... Cancer cell 28 (2), 155-169, 2015 | 117 | 2015 |
| In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K–AKT Signaling at Endosomes C Li Chew, A Lunardi, F Gulluni, DT Ruan, M Chen, L Salmena, ... Cancer discovery 5 (7), 740-751, 2015 | 111 | 2015 |
| A SP1/MIZ1/MYCN Repression Complex Recruits HDAC1 at the TRKA and p75NTR Promoters and Affects Neuroblastoma Malignancy by Inhibiting the Cell … N Iraci, D Diolaiti, A Papa, A Porro, E Valli, S Gherardi, S Herold, M Eilers, ... Cancer research 71 (2), 404-412, 2011 | 111 | 2011 |
| Vulnerabilities of PTEN–TP53-Deficient Prostate Cancers to Compound PARP–PI3K Inhibition E González-Billalabeitia, N Seitzer, SJ Song, MS Song, A Patnaik, XS Liu, ... Cancer discovery 4 (8), 896-904, 2014 | 99 | 2014 |
| Role of aberrant PI3K pathway activation in gallbladder tumorigenesis A Lunardi, KA Webster, A Papa, B Padmani, JG Clohessy, RT Bronson, ... Oncotarget 5 (4), 894, 2014 | 64 | 2014 |
| Functional cooperation between TrkA and p75NTR accelerates neuronal differentiation by increased transcription of GAP-43 and p21 (CIP/WAF) genes via ERK1/2 and AP-1 activities D Diolaiti, R Bernardoni, S Trazzi, A Papa, A Porro, F Bono, JM Herbert, ... Experimental cell research 313 (14), 2980-2992, 2007 | 54 | 2007 |
| PTEN and Other PtdIns(3,4,5)P3 Lipid Phosphatases in Breast Cancer MP Csolle, LM Ooms, A Papa, CA Mitchell International Journal of Molecular Sciences 21 (23), 9189, 2020 | 51 | 2020 |
| INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer SJ Rodgers, LM Ooms, VMJ Oorschot, RB Schittenhelm, EV Nguyen, ... Nature communications 12 (1), 3140, 2021 | 46 | 2021 |
| The PTEN tumor suppressor forms homodimers in solution F Heinrich, S Chakravarthy, H Nanda, A Papa, PP Pandolfi, AH Ross, ... Structure 23 (10), 1952-1957, 2015 | 45 | 2015 |
| GILZ-dependent modulation of mTORC1 regulates spermatogonial maintenance HM La, AL Chan, JMD Legrand, FJ Rossello, CG Gangemi, A Papa, ... Development 145 (18), dev165324, 2018 | 41 | 2018 |
Pier Paolo PandolfiDirector, Cancer Center and Cancer Research Institute, Beth Israel Deaconess Medical CenterVerified email at bidmc.harvard.edu
