|Mechanical destabilization induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration|
J Melrose, C Shu, C Young, R Ho, MM Smith, AA Young, SS Smith, ...
Spine 37 (1), 18-25, 2012
|Multifidus muscle changes after back injury are characterized by structural remodeling of muscle, adipose and connective tissue, but not muscle atrophy|
PW Hodges, G James, L Blomster, L Hall, A Schmid, C Shu, C Little, ...
Spine 40 (14), 1057-1071, 2015
|The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation|
J Melrose, C Shu, JM Whitelock, MS Lord
Matrix Biology 52, 363-383, 2016
|Comparative immunolocalisation of perlecan with collagen II and aggrecan in human foetal, newborn and adult ovine joint tissues demonstrates perlecan as an early developmental …|
SM Smith, C Shu, J Melrose
Histochemistry and cell biology 134 (3), 251-263, 2010
|Allogeneic mesenchymal precursor cells promote healing in postero-lateral annular lesions and improve indices of lumbar intervertebral disc degeneration in an ovine model|
BJC Freeman, JS Kuliwaba, CF Jones, CC Shu, CJ Colloca, ...
Spine 41 (17), 1331-1339, 2016
|Ablation of perlecan domain 1 heparan sulfate reduces progressive cartilage degradation, synovitis, and osteophyte size in a preclinical model of posttraumatic osteoarthritis|
CC Shu, MT Jackson, MM Smith, SM Smith, S Penm, MS Lord, ...
Arthritis & Rheumatology 68 (4), 868-879, 2016
|Can proinflammatory cytokine gene expression explain multifidus muscle fiber changes after an intervertebral disc lesion?|
PW Hodges, G James, L Blomster, L Hall, AB Schmid, C Shu, C Little, ...
Spine 39 (13), 1010-1017, 2014
|A histopathological scheme for the quantitative scoring of intervertebral disc degeneration and the therapeutic utility of adult mesenchymal stem cells for intervertebral disc …|
CC Shu, MM Smith, SM Smith, AJ Dart, CB Little, J Melrose
International journal of molecular sciences 18 (5), 1049, 2017
|Use of FGF-2 and FGF-18 to direct bone marrow stromal stem cells to chondrogenic and osteogenic lineages|
C Shu, SM Smith, CB Little, J Melrose
Future science OA 2 (4), FSO142, 2016
|The ovine newborn and human foetal intervertebral disc contain perlecan and aggrecan variably substituted with native 7D4 CS sulphation motif: spatiotemporal immunolocalisation …|
C Shu, C Hughes, SM Smith, MM Smith, A Hayes, B Caterson, CB Little, ...
Glycoconjugate journal 30 (7), 717-725, 2013
|Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral disc|
AJ Hayes, CC Shu, MS Lord, CB Little, JM Whitelock, J Melrose
European Cells and Materials 32, 40-57, 2016
|Macrophage polarization contributes to local inflammation and structural change in the multifidus muscle after intervertebral disc injury|
G James, KA Sluka, L Blomster, L Hall, AB Schmid, CC Shu, CB Little, ...
European Spine Journal 27 (8), 1744-1756, 2018
|Hyaluronan oligosaccharides stimulate matrix metalloproteinase and anabolic gene expression in vitro by intervertebral disc cells and annular repair in vivo|
ES Fuller, C Shu, MM Smith, CB Little, J Melrose
Journal of tissue engineering and regenerative medicine 12 (1), e216-e226, 2018
|Catabolism of fibromodulin in developmental rudiment and pathologic articular cartilage demonstrates novel roles for MMP-13 and ADAMTS-4 in C-terminal processing of SLRPs|
CC Shu, CR Flannery, CB Little, J Melrose
International journal of molecular sciences 20 (3), 579, 2019
|Mesenchymal stem cell treatment of intervertebral disc lesion prevents fatty infiltration and fibrosis of the multifidus muscle, but not cytokine and muscle fiber changes|
G James, L Blomster, L Hall, AB Schmid, CC Shu, CB Little, J Melrose, ...
Spine 41 (15), 1208-1217, 2016
|Confocal microscopy demonstrates association of LTBP-2 in fibrillin-1 microfibrils and colocalisation with perlecan in the disc cell pericellular matrix|
AJ Hayes, MA Gibson, C Shu, J Melrose
Tissue and Cell 46 (3), 185-197, 2014
|Comparative immunolocalisation of perlecan, heparan sulphate, fibroblast growth factor-18, and fibroblast growth factor receptor-3 and their prospective roles in chondrogenic …|
C Shu, SS Smith, CB Little, J Melrose
European Spine Journal 22 (8), 1774-1784, 2013
|The heparan sulphate deficient Hspg2 exon 3 null mouse displays reduced deposition of TGF-β1 in skin compared to C57BL/6 wild type mice|
C Shu, SM Smith, J Melrose
Journal of molecular histology 47 (3), 365-374, 2016
|Efficacy of administered mesenchymal stem cells in the initiation and co‐ordination of repair processes by resident disc cells in an ovine (Ovis aries) large …|
CC Shu, A Dart, R Bell, C Dart, E Clarke, MM Smith, CB Little, J Melrose
JOR spine 1 (4), e1037, 2018
|The relationship between synovial inflammation, structural pathology, and pain in post-traumatic osteoarthritis: differential effect of stem cell and hyaluronan treatment|
CC Shu, S Zaki, V Ravi, A Schiavinato, MM Smith, CB Little
Arthritis research & therapy 22 (1), 1-13, 2020