| A biparatopic HER2-targeting antibody-drug conjugate induces tumor regression in primary models refractory to or ineligible for HER2-targeted therapy JY Li, SR Perry, V Muniz-Medina, X Wang, LK Wetzel, MC Rebelatto, ... Cancer cell 29 (1), 117-129, 2016 | 349 | 2016 |
| Mechanism and In Vitro Pharmacology of TAK1 Inhibition by (5Z)-7-Oxozeaenol J Wu, F Powell, NA Larsen, Z Lai, KF Byth, J Read, RF Gu, M Roth, ... ACS chemical biology 8 (3), 643-650, 2013 | 156 | 2013 |
| Structure-based design of protein tyrosine phosphatase-1B inhibitors E Black, J Breed, AL Breeze, K Embrey, R Garcia, TW Gero, L Godfrey, ... Bioorganic & medicinal chemistry letters 15 (10), 2503-2507, 2005 | 108 | 2005 |
| Structural approaches to obtain kinase selectivity RA Norman, D Toader, AD Ferguson Trends in pharmacological sciences 33 (5), 273-278, 2012 | 99 | 2012 |
| Discovery of Checkpoint Kinase Inhibitor (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by Structure-Based Design and … V Oza, S Ashwell, L Almeida, P Brassil, J Breed, C Deng, T Gero, ... Journal of medicinal chemistry 55 (11), 5130-5142, 2012 | 74 | 2012 |
| First General Synthesis of (p-Nitroaryl)diarylmethanes via Vicarious Nucleophilic Substitution of Hydrogen AR Katritzky, D Toader The Journal of Organic Chemistry 62 (12), 4137-4141, 1997 | 67 | 1997 |
| Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors JW Janetka, L Almeida, S Ashwell, PJ Brassil, K Daly, C Deng, T Gero, ... Bioorganic & Medicinal Chemistry Letters 18 (14), 4242-4248, 2008 | 62 | 2008 |
| Essential role of TAK1 in regulating mantle cell lymphoma survival D Buglio, S Palakurthi, K Byth, F Vega, D Toader, J Saeh, SS Neelapu, ... Blood, The Journal of the American Society of Hematology 120 (2), 347-355, 2012 | 61 | 2012 |
| General and Efficient Carbon Insertion Route to One-Carbon-Homologated. alpha.-Aryl,. alpha.-Alkenyl,. alpha.-Alkoxy, and. alpha.-Phenylthio Alkyl Ketones AR Katritzky, L Xie, D Toader, L Serdyuk Journal of the American Chemical Society 117 (48), 12015-12016, 1995 | 48 | 1995 |
| Syntheses of 2-alkylamino-and 2-dialkylamino-4, 6-diarylpyridines and 2, 4, 6-trisubstituted pyrimidines using solid-phase-bound chalcones AR Katritzky, L Serdyuk, C Chassaing, D Toader, X Wang, B Forood, ... Journal of Combinatorial Chemistry 2 (2), 182-185, 2000 | 46 | 2000 |
| General and Efficient Insertions of Carbons Carrying Aryl and Heteroaryl Groups: Synthesis of α-Aryl-and α-Heteroaryl-Substituted Ketones AR Katritzky, D Toader, L Xie The Journal of Organic Chemistry 61 (21), 7571-7577, 1996 | 46 | 1996 |
| Preclinical evaluation of MEDI0641, a pyrrolobenzodiazepine-conjugated antibody–drug conjugate targeting 5T4 J Harper, C Lloyd, N Dimasi, D Toader, R Marwood, L Lewis, D Bannister, ... Molecular Cancer Therapeutics 16 (8), 1576-1587, 2017 | 38 | 2017 |
| Straightforward glycoengineering approach to site-specific antibody–pyrrolobenzodiazepine conjugates P Thompson, E Ezeadi, I Hutchinson, R Fleming, B Bezabeh, J Lin, S Mao, ... ACS Medicinal Chemistry Letters 7 (11), 1005-1008, 2016 | 36 | 2016 |
| New synthesis of SASRIN™ resin AR Katrizky, D Toader, K Watson, JS Kiely Tetrahedron letters 38 (45), 7849-7850, 1997 | 30 | 1997 |
| Efficient Transformations of Aldehydes and Ketones into One-Carbon Homologated Carboxylic Acids AR Katritzky, D Toader, L Xie Synthesis 1996 (12), 1425-1427, 1996 | 30 | 1996 |
| Identification of azabenzimidazoles as potent JAK1 selective inhibitors MM Vasbinder, M Alimzhanov, M Augustin, G Bebernitz, K Bell, ... Bioorganic & medicinal chemistry letters 26 (1), 60-67, 2016 | 27 | 2016 |
| Masked α-Arylalkenyllithium Reagents for Efficient Syntheses of Functionalized Monosubstituted and 1, 1-Disubstituted Ethylenes AR Katritzky, D Toader Journal of the American Chemical Society 119 (39), 9321-9322, 1997 | 27 | 1997 |
| Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors V Oza, S Ashwell, P Brassil, J Breed, J Ezhuthachan, C Deng, M Grondine, ... Bioorganic & medicinal chemistry letters 22 (6), 2330-2337, 2012 | 26 | 2012 |
| Discovery of a novel class of triazolones as Checkpoint Kinase inhibitors—Hit to lead exploration V Oza, S Ashwell, P Brassil, J Breed, C Deng, J Ezhuthachan, H Haye, ... Bioorganic & medicinal chemistry letters 20 (17), 5133-5138, 2010 | 26 | 2010 |
| Adventures in scaffold morphing: discovery of fused ring heterocyclic checkpoint kinase 1 (CHK1) inhibitors B Yang, MM Vasbinder, AW Hird, Q Su, H Wang, Y Yu, D Toader, ... Journal of Medicinal Chemistry 61 (3), 1061-1073, 2018 | 22 | 2018 |
