Tony Ngo
Tony Ngo
Sanford Burnham Prebys Medical Discovery Institute
Verified email at
Cited by
Cited by
Identifying ligands at orphan GPCRs: current status using structure‐based approaches
T Ngo, I Kufareva, JLJ Coleman, RM Graham, R Abagyan, NJ Smith
British journal of pharmacology 173 (20), 2934-2951, 2016
Orphan receptor ligand discovery by pickpocketing pharmacological neighbors
T Ngo, AV Ilatovskiy, AG Stewart, JLJ Coleman, FM McRobb, RP Riek, ...
Nature Chemical Biology 13 (2), 235-242, 2017
Metalloprotease cleavage of the N terminus of the orphan G protein–coupled receptor GPR37L1 reduces its constitutive activity
JLJ Coleman, T Ngo, J Schmidt, N Mrad, CK Liew, NM Jones, ...
Science Signaling 9 (423), ra36-ra36, 2016
The G protein-coupled receptor N-terminus and receptor signalling: N-tering a new era
JLJ Coleman, T Ngo, NJ Smith
Cellular signalling 33, 1-9, 2017
Rapid knockout and reporter mouse line generation and breeding colony establishment using eUCoMM conditional-ready embryonic stem cells: a case study
JLJ Coleman, K Brennan, T Ngo, P Balaji, RM Graham, NJ Smith
Frontiers in endocrinology 6, 105, 2015
5-HT1A receptor pharmacophores to screen for off-target activity of α1-adrenoceptor antagonists
T Ngo, TJ Nicholas, J Chen, AM Finch, R Griffith
Journal of computer-aided molecular design 27 (4), 305-319, 2013
Structural basis for GPCR-independent activation of heterotrimeric Gi proteins
NA Kalogriopoulos, SD Rees, T Ngo, NJ Kopcho, AV Ilatovskiy, N Sun, ...
Proceedings of the National Academy of Sciences 116 (33), 16394-16403, 2019
Using constitutive activity to define appropriate high-throughput screening assays for orphan G protein-coupled receptors
T Ngo, JLJ Coleman, NJ Smith
G Protein-Coupled Receptor Screening Assays, 91-106, 2015
Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity
T Ngo, BS Stephens, M Gustavsson, LG Holden, R Abagyan, TM Handel, ...
PLoS Biol 18 (4), e3000656, 2020
Functional anatomy of the full length CXCR4-CXCL12 complex systematically dissected by quantitative model-guided mutagenesis
BS Stephens, T Ngo, I Kufareva, TM Handel
bioRxiv, 2020
Analysis of drug binding pockets and repurposing opportunities for twelve essential enzymes of ESKAPE pathogens
S Naz, T Ngo, U Farooq, R Abagyan
PeerJ 5, e3765, 2017
The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases
JLJ Coleman, T Ngo, RE Smythe, AJ Cleave, NM Jones, RM Graham, ...
bioRxiv, 2020
Tackling the complexities of orphan GPCR ligand discovery with rationally assisted approaches
SS So, T Ngo, P Keov, NJ Smith, I Kufareva
GPCRs, 295-334, 2020
Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control
JLJ Coleman, MA Mouat, J Wu, N Jancovski, JK Bassi, AY Chan, ...
Biology of Sex Differences 9 (1), 14, 2018
Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi
N Kalogriopoulos, I Lopez-Sanchez, C Lin, T Ngo, K Midde, S Roy, ...
bioRxiv, 2020
SHOWCASE ON RESEARCH Structure-based Drug Design and Drug Discovery for G Protein-coupled Receptors
T Ngo, A Finch, R Griffith
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