| The Concise Guide to Pharmacology 2021/22: G protein‐coupled receptors SPH Alexander, A Christopoulos, AP Davenport, E Kelly, A Mathie, ... British Journal of Pharmacology 178, S27-S156, 2021 | 445 | 2021 |
| Identifying ligands at orphan GPCRs: current status using structure‐based approaches T Ngo, I Kufareva, JLJ Coleman, RM Graham, R Abagyan, NJ Smith British journal of pharmacology 173 (20), 2934-2951, 2016 | 94 | 2016 |
| Orphan receptor ligand discovery by pickpocketing pharmacological neighbors T Ngo, AV Ilatovskiy, AG Stewart, JLJ Coleman, FM McRobb, RP Riek, ... Nature Chemical Biology 13 (2), 235-242, 2017 | 56 | 2017 |
| Rapid knockout and reporter mouse line generation and breeding colony establishment using EUCOMM conditional-ready embryonic stem cells: a case study JLJ Coleman, K Brennan, T Ngo, P Balaji, RM Graham, NJ Smith Frontiers in endocrinology 6, 105, 2015 | 46 | 2015 |
| The G protein-coupled receptor N-terminus and receptor signalling: N-tering a new era JLJ Coleman, T Ngo, NJ Smith Cellular signalling 33, 1-9, 2017 | 45 | 2017 |
| Structural basis for GPCR-independent activation of heterotrimeric Gi proteins NA Kalogriopoulos, SD Rees, T Ngo, NJ Kopcho, AV Ilatovskiy, N Sun, ... Proceedings of the National Academy of Sciences 116 (33), 16394-16403, 2019 | 43 | 2019 |
| Functional anatomy of the full length CXCR4-CXCL12 complex systematically dissected by quantitative model-guided mutagenesis BS Stephens, T Ngo, I Kufareva, TM Handel Sci Signal 13 (640), eaay5024, 2020 | 35 | 2020 |
| Metalloprotease cleavage of the N terminus of the orphan G protein–coupled receptor GPR37L1 reduces its constitutive activity JLJ Coleman, T Ngo, J Schmidt, N Mrad, CK Liew, NM Jones, ... Science Signaling 9 (423), ra36-ra36, 2016 | 35 | 2016 |
| Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi NA Kalogriopoulos, I Lopez-Sanchez, C Lin, T Ngo, KK Midde, S Roy, ... Proceedings of the National Academy of Sciences 117 (46), 28763-28774, 2020 | 24 | 2020 |
| Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity T Ngo, BS Stephens, M Gustavsson, LG Holden, R Abagyan, TM Handel, ... PLoS Biol 18 (4), e3000656, 2020 | 24 | 2020 |
| Ponesimod inhibits astrocyte‐mediated neuroinflammation and protects against cingulum demyelination via S1P1‐selective modulation Y Kihara, D Jonnalagadda, Y Zhu, M Ray, T Ngo, C Palmer, R Rivera, ... The FASEB Journal 36 (2), 2022 | 15 | 2022 |
| 5-HT1A receptor pharmacophores to screen for off-target activity of α1-adrenoceptor antagonists T Ngo, TJ Nicholas, J Chen, AM Finch, R Griffith Journal of computer-aided molecular design 27 (4), 305-319, 2013 | 12 | 2013 |
| The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases JLJ Coleman, T Ngo, RE Smythe, AJ Cleave, NM Jones, RM Graham, ... Scientific Reports 10 (1), 19995, 2020 | 11 | 2020 |
| Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control JLJ Coleman, MA Mouat, J Wu, N Jancovski, JK Bassi, AY Chan, ... Biology of sex Differences 9, 1-13, 2018 | 11 | 2018 |
| Analysis of drug binding pockets and repurposing opportunities for twelve essential enzymes of ESKAPE pathogens S Naz, T Ngo, U Farooq, R Abagyan PeerJ 5, e3765, 2017 | 10 | 2017 |
| A circuit for secretion‐coupled cellular autonomy in multicellular eukaryotic cells L Qiao, S Sinha, AA Abd El‐Hafeez, IC Lo, KK Midde, T Ngo, N Aznar, ... Molecular Systems Biology 19 (4), e11127, 2023 | 9 | 2023 |
| Orphan receptor GPR37L1 remains unliganded T Ngo, BP Wilkins, SS So, P Keov, KK Chahal, AM Finch, JLJ Coleman, ... Nature Chemical Biology 17 (4), 383-386, 2021 | 9 | 2021 |
| A long isoform of GIV/Girdin contains a PDZ-binding module that regulates localization and G-protein binding J Ear, AA Abd El-Hafeez, S Roy, T Ngo, N Rajapakse, J Choi, ... Journal of Biological Chemistry 296, 2021 | 9 | 2021 |
| Tackling the complexities of orphan GPCR ligand discovery with rationally assisted approaches SS So, T Ngo, P Keov, NJ Smith, I Kufareva GPCRs, 295-334, 2020 | 9 | 2020 |
| Using constitutive activity to define appropriate high-throughput screening assays for orphan g protein-coupled receptors T Ngo, JLJ Coleman, NJ Smith G Protein-Coupled Receptor Screening Assays: Methods and Protocols, 91-106, 2015 | 9 | 2015 |
