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Megan Astle
Megan Astle
Verified email at monash.edu
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Year
AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy
MV Astle, KM Hannan, PY Ng, RS Lee, AJ George, AK Hsu, Y Haupt, ...
Oncogene 31 (15), 1949-1962, 2012
2762012
AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer
JC Chan, KM Hannan, K Riddell, PY Ng, A Peck, RS Lee, S Hung, ...
Science signaling 4 (188), ra56-ra56, 2011
1672011
The inositol polyphosphate 5-phosphatase, PIPP, is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation
LM Ooms, CG Fedele, MV Astle, I Ivetac, V Cheung, RB Pearson, ...
Molecular biology of the cell 17 (2), 607-622, 2006
872006
The SH2 domain containing inositol polyphosphate 5-phosphatase-2: SHIP2
JM Dyson, AM Kong, F Wiradjaja, MV Astle, R Gurung, CA Mitchell
The international journal of biochemistry & cell biology 37 (11), 2260-2265, 2005
762005
The inositol polyphosphate 5-phosphatases: traffic controllers, waistline watchers and tumour suppressors?
MV Astle, KA Horan, LM Ooms, CA Mitchell
Biochemical Society Symposia 74, 161-181, 2007
702007
The mTORC1 Inhibitor Everolimus Prevents and Treats Eμ-Myc Lymphoma by Restoring Oncogene-Induced Senescence
M Wall, G Poortinga, KL Stanley, RK Lindemann, M Bots, CJ Chan, ...
Cancer discovery 3 (1), 82-95, 2013
682013
Regulation of phosphoinositide signaling by the inositol polyphosphate 5‐phosphatases
MV Astle, G Seaton, EM Davies, CG Fedele, P Rahman, L Arsala, ...
Iubmb Life 58 (8), 451-456, 2006
622006
P-Rex1–a multidomain protein that regulates neurite differentiation
JAE Waters, MV Astle, LM Ooms, D Balamatsias, R Gurung, CA Mitchell
Journal of cell science 121 (17), 2892-2903, 2008
532008
Identification of a proline-rich inositol polyphosphate 5-phosphatase (PIPP)· collapsin response mediator protein 2 (CRMP2) complex that regulates neurite elongation
MV Astle, LM Ooms, AR Cole, LC Binge, JM Dyson, MJ Layton, S Petratos, ...
Journal of Biological Chemistry 286 (26), 23407-23418, 2011
242011
AKT is a critical regulator of rRNA synthesis and cooperates with c-MYC to control ribosome biogenesis in cancer
JC Chan, KM Hannan, K Riddell, PY Ng, A Peck, RS Lee, S Hung, ...
Science Signaling 4 (188), ra56, 2011
12011
The 5-phosphatase PIPP binds CRMP proteins and is a novel regulator of neuron differentiation
MV Astle
Monash University, 2008
12008
Analyze p53 degradation by 35S p53 Pulse Chase Analysis
M Astle, R Pearson, K Hannan
Bio-protocol 2 (21), e283-e283, 2012
2012
594 A novel form of cellular senescence induced by hyper-activation of the PI3K/Akt pathway
MV Astle, RD Hannan, RB Pearson
ejc supplements 5 (8), 151, 2010
2010
SHOWCASE ON RESEARCH
M Astle, G Seaton, M Davies, C Fedele, P Rahman, L Arsala, C Mitchell
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