A Genomic Safe Haven for Mutant Complementation in Cryptococcus neoformans SDM Arras, JL Chitty, KL Blake, BL Schulz, JA Fraser PloS one 10 (4), e0122916, 2015 | 87 | 2015 |
Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans RD Blundell, SJ Williams, SDM Arras, JL Chitty, KL Blake, DJ Ericsson, ... ACS infectious diseases 2 (9), 651-663, 2016 | 22 | 2016 |
Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7 AJ Agwa, P Tran, A Mueller, HNT Tran, JR Deuis, MR Israel, KL McMahon, ... Journal of Biological Chemistry 295 (15), 5067-5080, 2020 | 20 | 2020 |
Small cyclic sodium channel inhibitors S Peigneur, C da Costa Oliveira, FC de Sousa Fonseca, KL McMahon, ... Biochemical pharmacology 183, 114291, 2021 | 17 | 2021 |
Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible NaV Channel Inhibitor KL McMahon, HNT Tran, JR Deuis, RJ Lewis, I Vetter, CI Schroeder Biomedicines 8 (10), 391, 2020 | 16 | 2020 |
Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design JL Chitty, KL Blake, RD Blundell, YQAE Koh, M Thompson, ... Journal of Biological Chemistry 292 (28), 11829-11839, 2017 | 15 | 2017 |
Structural and functional insights into the inhibition of human voltage-gated sodium channels by μ-conotoxin KIIIA disulfide isomers HNT Tran, KL McMahon, JR Deuis, I Vetter, CI Schroeder Journal of Biological Chemistry 298 (3), 2022 | 9 | 2022 |
The Tarantula Venom Peptide Eo1a Binds to the Domain II S3-S4 Extracellular Loop of Voltage-Gated Sodium Channel NaV1.8 to Enhance Activation JR Deuis, L Ragnarsson, SD Robinson, Z Dekan, L Chan, AH Jin, P Tran, ... Frontiers in Pharmacology 12, 789570, 2022 | 7 | 2022 |
Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function S Jami, JR Deuis, T Klasfauseweh, X Cheng, S Kurdyukov, F Chung, ... Nature Communications 14 (1), 2442, 2023 | 6 | 2023 |
Evaluation of efficient non-reducing enzymatic and chemical ligation strategies for complex disulfide-rich peptides HNT Tran, P Tran, JR Deuis, KL McMahon, K Yap, DJ Craik, I Vetter, ... Bioconjugate chemistry 32 (11), 2407-2419, 2021 | 6 | 2021 |
µ-Conotoxins Targeting the Human Voltage-Gated Sodium Channel Subtype NaV1.7 KL McMahon, HNT Tran, JR Deuis, DJ Craik, I Vetter, CI Schroeder Toxins 14 (9), 600, 2022 | 4 | 2022 |
Pharmacological activity and NMR solution structure of the leech peptide HSTX-I KL McMahon, B Tay, JR Deuis, BS Tanaka, S Peigneur, AH Jin, J Tytgat, ... Biochemical pharmacology 181, 114082, 2020 | 4 | 2020 |
Identification of sodium channel toxins from marine cone snails of the subgenera Textilia and Afonsoconus KL McMahon, H O’Brien, CI Schroeder, JR Deuis, D Venkatachalam, ... Cellular and Molecular Life Sciences 80 (10), 287, 2023 | 1 | 2023 |
Voltage-Gated Sodium Channel Inhibition by µ-Conotoxins KL McMahon, I Vetter, CI Schroeder Toxins 16 (1), 55, 2024 | | 2024 |
Changes in Potency and Subtype Selectivity of Bivalent NaV Toxins are Knot-Specific P Tran, HNT Tran, KL McMahon, JR Deuis, L Ragnarsson, A Norman, ... Bioconjugate Chemistry 34 (6), 1072-1083, 2023 | | 2023 |
Solving painful problems: Developing potent and selective NaV channel inhibitors from animal venom KL McMahon | | 2021 |