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Gerhard Leinenga
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Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model
G Leinenga, J Götz
Science translational medicine 7 (278), 278ra33-278ra33, 2015
5512015
Ultrasound treatment of neurological diseases—current and emerging applications
G Leinenga, C Langton, R Nisbet, J Götz
Nature Reviews Neurology 12 (3), 161-174, 2016
2342016
Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model
RM Nisbet, A Van der Jeugd, G Leinenga, HT Evans, PW Janowicz, ...
Brain 140 (5), 1220-1230, 2017
1822017
Repeated ultrasound treatment of tau transgenic mice clears neuronal tau by autophagy and improves behavioral functions
R Pandit, G Leinenga, J Götz
Theranostics 9 (13), 3754, 2019
932019
What renders TAU toxic
J Götz, D Xia, G Leinenga, YL Chew, HR Nicholas
Frontiers in neurology 4, 72, 2013
882013
Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody
PW Janowicz, G Leinenga, J Götz, RM Nisbet
Scientific reports 9 (1), 9255, 2019
652019
A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer disease
G Leinenga, WK Koh, J Götz
Alzheimer's research & therapy 13, 1-14, 2021
592021
Safety and efficacy of scanning ultrasound treatment of aged APP23 mice
G Leinenga, J Götz
Frontiers in neuroscience 12, 328839, 2018
582018
Establishing sheep as an experimental species to validate ultrasound-mediated blood-brain barrier opening for potential therapeutic interventions
M Pelekanos, G Leinenga, M Odabaee, M Odabaee, S Saifzadeh, ...
Theranostics 8 (9), 2583, 2018
382018
Scanning ultrasound (SUS) causes no changes to neuronal excitability and prevents age-related reductions in hippocampal CA1 dendritic structure in wild-type mice
RJ Hatch, G Leinenga, J Götz
PLoS One 11 (10), e0164278, 2016
282016
Scanning ultrasound in the absence of blood-brain barrier opening is not sufficient to clear β-amyloid plaques in the APP23 mouse model of Alzheimer's disease
G Leinenga, WK Koh, J Götz
Brain Research Bulletin 153, 8-14, 2019
252019
A sporadic Alzheimer's blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies
JM Wasielewska, JCS Chaves, RL Johnston, LA Milton, D Hernández, ...
Theranostics 12 (16), 6826, 2022
182022
Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model
L Chen, R Sutharsan, JLF Lee, E Cruz, B Asnicar, T Palliyaguru, ...
Theranostics 12 (5), 1952, 2022
152022
Modeling ultrasound propagation through material of increasing geometrical complexity
M Odabaee, M Odabaee, M Pelekanos, G Leinenga, J Götz
Ultrasonics 90, 52-62, 2018
132018
Transcriptional signature in microglia isolated from an Alzheimer's disease mouse model treated with scanning ultrasound
G Leinenga, LG Bodea, J Schröder, G Sun, Y Zhou, J Song, A Grubman, ...
Bioengineering & Translational Medicine 8 (1), e10329, 2023
112023
Delivery of antibodies into the brain using focused scanning ultrasound
G Leinenga, LG Bodea, WK Koh, RM Nisbet, J Götz
JoVE (Journal of Visualized Experiments), e61372, 2020
62020
5th International Symposium on Focused Ultrasound: North Bethesda, MD, USA. 28 August-1 September 2016
M Zaaroor, A Sinai, D Goldsher, A Eran, M Nassar, I Schlesinger, J Parker, ...
Journal of Therapeutic Ultrasound 4, 1-113, 2016
22016
Ultrasound as a treatment modality for neurological diseases
G Leinenga, RM Nisbet, J Götz
The Medical Journal of Australia 206 (11), 470-471, 2017
12017
Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction
G Leinenga, XV To, LG Bodea, J Yousef, G Richter-Stretton, T Palliyaguru, ...
Molecular Psychiatry, 1-16, 2024
2024
Scanning ultrasound improves memory and enhances functional outcomes in Alzheimer mice in the absence of amyloid-beta reduction
G Leinenga, XV To, L Bodea, J Yousef, G Richter-Stretton, T Palliyaguru, ...
2023
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