| Integrins as therapeutic targets: lessons and opportunities D Cox, M Brennan, N Moran Nature reviews Drug discovery 9 (10), 804-820, 2010 | 596 | 2010 |
| Open source drug discovery with the malaria box compound collection for neglected diseases and beyond WC Van Voorhis, JH Adams, R Adelfio, V Ahyong, MH Akabas, P Alano, ... PLoS pathogens 12 (7), e1005763, 2016 | 294 | 2016 |
| Fibronectin‐binding proteins of Staphylococcus aureus mediate activation of human platelets via fibrinogen and fibronectin bridges to integrin GPIIb/IIIa and IgG … JR Fitzgerald, A Loughman, F Keane, M Brennan, M Knobel, J Higgins, ... Molecular microbiology 59 (1), 212-230, 2006 | 234 | 2006 |
| Roles for fibrinogen, immunoglobulin and complement in platelet activation promoted by Staphylococcus aureus clumping factor A A Loughman, JR Fitzgerald, MP Brennan, J Higgins, R Downer, D Cox, ... Molecular microbiology 57 (3), 804-818, 2005 | 226 | 2005 |
| Fibrinogen and elastin bind to the same region within the A domain of fibronectin binding protein A, an MSCRAMM of Staphylococcus aureus FM Keane, A Loughman, V Valtulina, M Brennan, P Speziale, TJ Foster Molecular microbiology 63 (3), 711-723, 2007 | 156 | 2007 |
| Elucidating the role of Staphylococcus epidermidis serine–aspartate repeat protein G in platelet activation MP Brennan, A Loughman, M Devocelle, S Arasu, AJ Chubb, TJ Foster, ... Journal of thrombosis and haemostasis 7 (8), 1364-1372, 2009 | 108 | 2009 |
| Molecular interactions and inhibition of the staphylococcal biofilm-forming protein SdrC C Feuillie, C Formosa-Dague, LMC Hays, O Vervaeck, S Derclaye, ... Proceedings of the National Academy of Sciences 114 (14), 3738-3743, 2017 | 104 | 2017 |
| Both Complement- and Fibrinogen-Dependent Mechanisms Contribute to Platelet Aggregation Mediated by Staphylococcus aureus Clumping Factor B H Miajlovic, A Loughman, M Brennan, D Cox, TJ Foster Infection and immunity 75 (7), 3335-3343, 2007 | 97 | 2007 |
| A novel platinum complex of the histone deacetylase inhibitor belinostat: rational design, development and in vitro cytotoxicity JP Parker, H Nimir, DM Griffith, B Duff, AJ Chubb, MP Brennan, ... Journal of Inorganic Biochemistry 124, 70-77, 2013 | 36 | 2013 |
| In Vitro Activities of Synthetic Host Defense Propeptides Processed by Neutrophil Elastase against Cystic Fibrosis Pathogens S Desgranges, F Le Prieult, A Daly, J Lydon, M Brennan, DK Rai, ... Antimicrobial agents and chemotherapy 55 (5), 2487-2489, 2011 | 17 | 2011 |
| C‐reactive protein binds to αIIbβ3 MP Brennan, RD Moriarty, S Grennan, AJ Chubb, D Cox Journal of thrombosis and haemostasis 6 (7), 1239-1241, 2008 | 17 | 2008 |
| A novel role for the fibrinogen Asn-Gly-Arg (NGR) motif in platelet function R Moriarty, CA McManus, M Lambert, T Tilley, M Devocelle, M Brennan, ... Thrombosis and Haemostasis 114 (02), 290-304, 2015 | 14 | 2015 |
| Genomes2Drugs: identifies target proteins and lead drugs from proteome data D Toomey, HC Hoppe, MP Brennan, KB Nolan, AJ Chubb PLoS One 4 (7), e6195, 2009 | 13 | 2009 |
| TIN− a combinatorial compound collection of synthetically feasible multicomponent synthesis products KV Dorschner, D Toomey, MP Brennan, T Heinemann, FJ Duffy, KB Nolan, ... Journal of chemical information and modeling 51 (5), 986-995, 2011 | 9 | 2011 |
| Peptide diversity in drug discovery MP Brennan, D Cox, AJ Chubb Frontiers in Drug Design & Discovery: Structure-Based Drug Design in the …, 2007 | 9 | 2007 |
| Impact of genetic variation in the 5-HT transporter and receptor on platelet function in patients with stable CAD taking aspirin A Bajrangee, N Ryan, C Vangjeli, M Brennan, D Cox, DC Shields, ... Thrombosis Research 146, 51-55, 2016 | 8 | 2016 |
| The therapeutic potential of I-domain integrins M Brennan, D Cox I Domain Integrins, 157-178, 2014 | 7 | 2014 |
| Combating Cancer with Precious Metals-A Multi-Functional Approach Towards Developing Novel Anti-Cancer Agents CJ Marmion, DM Griffith, J Parker, Z Ude, H Nimir, M Morgan, M Brennan, ... JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 19, S463-S463, 2014 | 6 | 2014 |
| Novel anti-staphylococcal and anti-biofilm properties of two anti-malarial compounds: MMV665953 {1-(3-chloro-4-fluorophenyl)-3-(3, 4-dichlorophenyl) urea} and MMV665807 {5 … M Zapotoczna, N Boksmati, S Donohue, B Bahtiar, A Boland, HA Somali, ... Journal of Medical Microbiology 66 (3), 377-387, 2017 | 4 | 2017 |
| Deadly Engagement: FcγRIIa–Antibody Interaction is Key in Sepsis MP Brennan Trends in Pharmacological Sciences 37 (12), 989-990, 2016 | 1 | 2016 |
Demot CoxRoyal College of Surgeons in IrelandVerified email at rcsi.ie
