Rick Pearson
Rick Pearson
Group Leader, Peter MacCallum Cancer Centre
Verified email at
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[3] Protein kinase phosphorylation site sequences and consensus specificity motifs: Tabulations
RB Pearson, BE Kemp
Methods in enzymology 200, 62-81, 1991
Protein kinase recognition sequence motifs
BE Kemp, RB Pearson
Trends in biochemical sciences 15 (9), 342-346, 1990
Rapamycin suppresses 5′ TOP mRNA translation through inhibition of p70s6k
HBJ Jefferies, S Fumagalli, PB Dennis, C Reinhard, RB Pearson, ...
The EMBO journal 16 (12), 3693-3704, 1997
Mutation of the PIK3CA gene in ovarian and breast cancer
IG Campbell, SE Russell, DYH Choong, KG Montgomery, ML Ciavarella, ...
Cancer research 64 (21), 7678-7681, 2004
A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase.
HC Cheng, BE Kemp, RB Pearson, AJ Smith, L Misconi, SM Van Patten, ...
Journal of Biological Chemistry 261 (3), 989-992, 1986
The Akt kinase signals directly to endothelial nitric oxide synthase
BJ Michell, JE Griffiths, KI Mitchelhill, I Rodriguez-Crespo, T Tiganis, ...
Current biology 9 (15), 845-S1, 1999
The principal target of rapamycin‐induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.
RB Pearson, PB Dennis, JW Han, NA Williamson, SC Kozma, ...
The EMBO journal 14 (21), 5279-5287, 1995
mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar …
KM Hannan, Y Brandenburger, A Jenkins, K Sharkey, A Cavanaugh, ...
Molecular and cellular biology 23 (23), 8862-8877, 2003
Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53
MJ Bywater, G Poortinga, E Sanij, N Hein, A Peck, C Cullinane, M Wall, ...
Cancer cell 22 (1), 51-65, 2012
Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function
K Jastrzebski, KM Hannan, EB Tchoubrieva, RD Hannan, RB Pearson
Growth factors 25 (4), 209-226, 2007
The calmodulin binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence.
BE Kemp, RB Pearson, V Guerriero Jr, IC Bagchi, AR Means
Journal of Biological Chemistry 262 (6), 2542-2548, 1987
Substrate specificity of a multifunctional calmodulin-dependent protein kinase.
RB Pearson, JR Woodgett, P Cohen, BE Kemp
Journal of Biological Chemistry 260 (27), 14471-14476, 1985
STIM1: a novel phosphoprotein located at the cell surface
SSM Manji, NJ Parker, RT Williams, L Van Stekelenburg, RB Pearson, ...
Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular …, 2000
Targeting PI3 kinase/AKT/mTOR signaling in cancer
K Sheppard, KM Kinross, B Solomon, RB Pearson, WA Phillips
Critical Reviews™ in Oncogenesis 17 (1), 2012
Regulatory and structural motifs of chicken gizzard myosin light chain kinase.
NJ Olson, RB Pearson, DS Needleman, MY Hurwitz, BE Kemp, AR Means
Proceedings of the National Academy of Sciences 87 (6), 2284-2288, 1990
Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis
C Darido, SR Georgy, T Wilanowski, S Dworkin, A Auden, Q Zhao, ...
Cancer cell 20 (5), 635-648, 2011
AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy
MV Astle, KM Hannan, PY Ng, RS Lee, AJ George, AK Hsu, Y Haupt, ...
Oncogene 31 (15), 1949-1962, 2012
Targeting the nucleolus for cancer intervention
JE Quin, JR Devlin, D Cameron, KM Hannan, RB Pearson, RD Hannan
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842 (6), 802-816, 2014
Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of GlycolysisRole of Glycolysis in Responses to BRAF Inhibition
TJ Parmenter, M Kleinschmidt, KM Kinross, ST Bond, J Li, MR Kaadige, ...
Cancer discovery 4 (4), 423-433, 2014
UBF levels determine the number of active ribosomal RNA genes in mammals
E Sanij, G Poortinga, K Sharkey, S Hung, TP Holloway, J Quin, E Robb, ...
The Journal of cell biology 183 (7), 1259-1274, 2008
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