|Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death|
JM Hildebrand, MC Tanzer, IS Lucet, SN Young, SK Spall, P Sharma, ...
Proceedings of the National Academy of Sciences 111 (42), 15072-15077, 2014
|DSB proteins and bacterial pathogenicity|
B Heras, SR Shouldice, M Totsika, MJ Scanlon, MA Schembri, JL Martin
Nature Reviews Microbiology 7 (3), 215-225, 2009
|Isolation, Solution Structure, and Insecticidal Activity of Kalata B2, a Circular Protein with a Twist: Do Möbius Strips Exist in Nature?,|
CV Jennings, KJ Rosengren, NL Daly, M Plan, J Stevens, MJ Scanlon, ...
Biochemistry 44 (3), 851-860, 2005
|Three-dimensional structure of a cysteine-rich repeat from the low-density lipoprotein receptor|
NL Daly, MJ Scanlon, JT Djordjevic, PA Kroon, R Smith
Proceedings of the National Academy of Sciences 92 (14), 6334-6338, 1995
|Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing|
DP Fairlie, JDA Tyndall, RC Reid, AK Wong, G Abbenante, MJ Scanlon, ...
Journal of medicinal chemistry 43 (7), 1271-1281, 2000
|The three-dimensional solution structure of NaD1, a new floral defensin from Nicotiana alata and its application to a homology model of the crop defense protein alfAFP|
FT Lay, HJ Schirra, MJ Scanlon, MA Anderson, DJ Craik
Journal of molecular biology 325 (1), 175-188, 2003
|The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling|
GM Gibbs, MJ Scanlon, J Swarbrick, S Curtis, E Gallant, AF Dulhunty, ...
Journal of Biological Chemistry 281 (7), 4156-4163, 2006
|Targeting virulence not viability in the search for future antibacterials|
B Heras, MJ Scanlon, JL Martin
British journal of clinical pharmacology 79 (2), 208-215, 2015
|A Backbone Linker for BOC-Based Peptide Synthesis and On-Resin Cyclization: Synthesis of Stylostatin 1,|
GT Bourne, WDF Meutermans, PF Alewood, RP McGeary, M Scanlon, ...
The Journal of organic chemistry 64 (9), 3095-3101, 1999
|Solution structure and proposed binding mechanism of a novel potassium channel toxin κ-conotoxin PVIIA|
MJ Scanlon, D Naranjo, L Thomas, PF Alewood, RJ Lewis, DJ Craik
Structure 5 (12), 1585-1597, 1997
|Difficult macrocyclizations: new strategies for synthesizing highly strained cyclic tetrapeptides|
WDF Meutermans, GT Bourne, SW Golding, DA Horton, MR Campitelli, ...
Organic letters 5 (15), 2711-2714, 2003
|Small heat-shock proteins interact with a flanking domain to suppress polyglutamine aggregation|
AL Robertson, SJ Headey, HM Saunders, H Ecroyd, MJ Scanlon, ...
Proceedings of the National Academy of Sciences 107 (23), 10424-10429, 2010
|Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3|
MKM Chow, JP Mackay, JC Whisstock, MJ Scanlon, SP Bottomley
Biochemical and biophysical research communications 322 (2), 387-394, 2004
|Characterization of the drug binding specificity of rat liver fatty acid binding protein|
S Chuang, T Velkov, J Horne, CJH Porter, MJ Scanlon
Journal of medicinal chemistry 51 (13), 3755-3764, 2008
|Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief|
DD Jensen, TM Lieu, ML Halls, NA Veldhuis, WL Imlach, QN Mai, ...
Science translational medicine 9 (392), 2017
|Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold|
SM Devine, MD Mulcair, CO Debono, EWW Leung, JWM Nissink, SS Lim, ...
Journal of medicinal chemistry 58 (3), 1205-1214, 2015
|Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?|
J Wielens, SJ Headey, DI Rhodes, RJ Mulder, O Dolezal, JJ Deadman, ...
Journal of biomolecular screening 18 (2), 147-159, 2013
|Solution structure of the cardiostimulant polypeptide anthopleurin-B and comparison with anthopleurin-A|
SA Monks, PK Pallaghy, MJ Scanlon, RS Norton
Structure 3 (8), 791-803, 1995
|Conformationally constrained macrocycles that mimic tripeptide β-strands in water and aprotic solvents|
RC Reid, MJ Kelso, MJ Scanlon, DP Fairlie
Journal of the American Chemical Society 124 (20), 5673-5683, 2002
|A novel two-chain proteinase inhibitor generated by circularization of a multidomain precursor protein|
MCS Lee, MJ Scanlon, DJ Craik, MA Anderson
Nature structural biology 6 (6), 526-530, 1999