Alexander A Khromykh
Alexander A Khromykh
NHMRC Senior Research Fellow, School of Chemistry and Molecular Biosciences, University of
Verified email at - Homepage
TitleCited byYear
Ultrastructure of Kunjin virus-infected cells: colocalization of NS1 and NS3 with double-stranded RNA, and of NS2B with NS3, in virus-induced membrane structures.
EG Westaway, JM Mackenzie, MT Kenney, MK Jones, AA Khromykh
Journal of virology 71 (9), 6650-6661, 1997
Essential role of cyclization sequences in flavivirus RNA replication
AA Khromykh, H Meka, KJ Guyatt, EG Westaway
Journal of virology 75 (14), 6719-6728, 2001
Subcellular localization and some biochemical properties of the flavivirus Kunjin nonstructural proteins NS2A and NS4A
JM Mackenzie, AA Khromykh, MK Jones, EG Westaway
Virology 245 (2), 203-215, 1998
Subgenomic replicons of the flavivirus Kunjin: construction and applications.
AA Khromykh, EG Westaway
Journal of virology 71 (2), 1497-1505, 1997
A highly structured, nuclease-resistant, noncoding RNA produced by flaviviruses is required for pathogenicity
GP Pijlman, A Funk, N Kondratieva, J Leung, S Torres, L Van der Aa, ...
Cell host & microbe 4 (6), 579-591, 2008
Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteins
WJ Liu, XJ Wang, VV Mokhonov, PY Shi, R Randall, AA Khromykh
Journal of virology 79 (3), 1934-1942, 2005
A single amino acid substitution in the West Nile virus nonstructural protein NS2A disables its ability to inhibit alpha/beta interferon induction and attenuates virus …
WJ Liu, XJ Wang, DC Clark, M Lobigs, RA Hall, AA Khromykh
Journal of virology 80 (5), 2396-2404, 2006
Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5
H Malet, MP Egloff, B Selisko, RE Butcher, PJ Wright, M Roberts, A Gruez, ...
Journal of Biological Chemistry 282 (14), 10678-10689, 2007
Cholesterol manipulation by West Nile virus perturbs the cellular immune response
JM Mackenzie, AA Khromykh, RG Parton
Cell host & microbe 2 (4), 229-239, 2007
Noncoding flavivirus RNA displays RNA interference suppressor activity in insect and Mammalian cells
E Schnettler, MG Sterken, JY Leung, SW Metz, C Geertsema, ...
Journal of virology 86 (24), 13486-13500, 2012
Coupling between replication and packaging of flavivirus RNA: evidence derived from the use of DNA-based full-length cDNA clones of Kunjin virus
AA Khromykh, AN Varnavski, PL Sedlak, EG Westaway
Journal of virology 75 (10), 4633-4640, 2001
The NS5 protein of the virulent West Nile virus NY99 strain is a potent antagonist of type I interferon-mediated JAK-STAT signaling
M Laurent-Rolle, EF Boer, KJ Lubick, JB Wolfinbarger, AB Carmody, ...
Journal of virology 84 (7), 3503-3515, 2010
Regulated cleavages at the West Nile virus NS4A-2K-NS4B junctions play a major role in rearranging cytoplasmic membranes and Golgi trafficking of the NS4A protein
J Roosendaal, EG Westaway, A Khromykh, JM Mackenzie
Journal of virology 80 (9), 4623-4632, 2006
Role of nonstructural protein NS2A in flavivirus assembly
JY Leung, GP Pijlman, N Kondratieva, J Hyde, JM Mackenzie, ...
Journal of virology 82 (10), 4731-4741, 2008
Molecular and functional analyses of Kunjin virus infectious cDNA clones demonstrate the essential roles for NS2A in virus assembly and for a nonconservative residue in NS3 in …
WJ Liu, HB Chen, AA Khromykh
Journal of virology 77 (14), 7804-7813, 2003
Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling
JJ Fros, WJ Liu, NA Prow, C Geertsema, M Ligtenberg, ...
Journal of virology 84 (20), 10877-10887, 2010
cis-and trans-acting elements in flavivirus RNA replication
AA Khromykh, PL Sedlak, EG Westaway
Journal of virology 74 (7), 3253-3263, 2000
West Nile virus encodes a microRNA-like small RNA in the 3′ untranslated region which up-regulates GATA4 mRNA and facilitates virus replication in mosquito cells
M Hussain, S Torres, E Schnettler, A Funk, A Grundhoff, GP Pijlman, ...
Nucleic acids research 40 (5), 2210-2223, 2011
Analysis of adaptive mutations in Kunjin virus replicon RNA reveals a novel role for the flavivirus nonstructural protein NS2A in inhibition of beta interferon promoter-driven …
WJ Liu, HB Chen, XJ Wang, H Huang, AA Khromykh
Journal of virology 78 (22), 12225-12235, 2004
trans-Complementation of flavivirus RNA polymerase gene NS5 by using Kunjin virus replicon-expressing BHK cells
AA Khromykh, MT Kenney, EG Westaway
Journal of virology 72 (9), 7270-7279, 1998
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