| Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation KT Lawlor, JM Vanslambrouck, JW Higgins, A Chambon, K Bishard, ... Nature materials 20 (2), 260-271, 2021 | 281 | 2021 |
| 3D proximal tubule tissues recapitulate key aspects of renal physiology to enable nephrotoxicity testing SM King, JW Higgins, CR Nino, TR Smith, EH Paffenroth, CE Fairbairn, ... Frontiers in physiology 8, 123, 2017 | 141 | 2017 |
| Ablation of both organic cation transporter (OCT) 1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics JW Higgins, DW Bedwell, MJ Zamek-Gliszczynski Drug metabolism and disposition 40 (6), 1170-1177, 2012 | 110 | 2012 |
| Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics MJ Zamek-Gliszczynski, DW Bedwell, JQ Bao, JW Higgins Drug Metabolism and Disposition 40 (9), 1825-1833, 2012 | 101 | 2012 |
| Utility of Oatp1a/1b-knockout and OATP1B1/3-humanized mice in the study of OATP-mediated pharmacokinetics and tissue distribution: case studies with pravastatin, atorvastatin … JW Higgins, JQ Bao, AB Ke, JR Manro, JK Fallon, PC Smith, ... Drug Metabolism and Disposition 42 (1), 182-192, 2014 | 95 | 2014 |
| Rhodamine inhibitors of P-glycoprotein: an amide/thioamide “switch” for ATPase activity MK Gannon, JJ Holt, SM Bennett, BR Wetzel, TW Loo, MC Bartlett, ... Journal of medicinal chemistry 52 (10), 3328-3341, 2009 | 73 | 2009 |
| Prediction of renal transporter mediated drug-drug interactions for pemetrexed using physiologically based pharmacokinetic modeling MM Posada, JA Bacon, KB Schneck, RG Tirona, RB Kim, JW Higgins, ... Drug Metabolism and Disposition 43 (3), 325-334, 2015 | 66 | 2015 |
| Induction of p16ink4a and p19ARF by TGFβ1 contributes to growth arrest and senescence response in mouse keratinocytes K Vijayachandra, W Higgins, J Lee, A Glick Molecular Carcinogenesis: Published in cooperation with the University of …, 2009 | 65 | 2009 |
| Itraconazole and clarithromycin as ketoconazole alternatives for clinical CYP3A inhibition studies AB Ke, MJ Zamek‐Gliszczynski, JW Higgins, SD Hall Clinical Pharmacology & Therapeutics 95 (5), 473-476, 2014 | 63 | 2014 |
| Prediction of transporter‐mediated drug‐drug interactions for baricitinib MM Posada, EA Cannady, CD Payne, X Zhang, JA Bacon, YA Pak, ... Clinical and Translational Science 10 (6), 509-519, 2017 | 57 | 2017 |
| Metformin sinusoidal efflux from the liver is consistent with negligible biliary excretion and absence of enterohepatic cycling MJ Zamek-Gliszczynski, JQ Bao, JS Day, JW Higgins Drug Metabolism and Disposition 41 (11), 1967-1971, 2013 | 32 | 2013 |
| Bioprinted pluripotent stem cell-derived kidney organoids provide opportunities for high content screening JW Higgins, A Chambon, K Bishard, A Hartung, D Arndt, J Brugnano, ... bioRxiv, 505396, 2018 | 25 | 2018 |
| Clinical CYP3A inhibitor alternatives to ketoconazole, clarithromycin and itraconazole, are not transported into the liver by hepatic organic anion transporting polypeptides … JW Higgins, AB Ke, MJ Zamek-Gliszczynski Drug metabolism and disposition 42 (11), 1780-1784, 2014 | 21 | 2014 |
| Chalcogenopyrylium dyes as inhibitors/modulators of P-glycoprotein in multidrug-resistant cells GA Sawada, TJ Raub, JW Higgins, NK Brennan, TM Moore, G Tombline, ... Bioorganic & medicinal chemistry 16 (22), 9745-9756, 2008 | 20 | 2008 |
| Characterization of JNJ-2482272 [4-(4-methyl-2-(4-(trifluoromethyl) phenyl) thiazole-5-yl) pyrimidine-2-amine] as a strong aryl hydrocarbon receptor activator in rat and human KJ Coe, M Feinstein, JW Higgins, P Leung, BP Scott, J Skaptason, Y Tam, ... Drug Metabolism and Disposition 50 (8), 1064-1076, 2022 | 3 | 2022 |
| Ablation of both Oct1 and Oct2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics JW Higgins, DW Bedwell, MJ Zamek-Gliszczynski Drug Metabolism and Disposition, 2012 | 3 | 2012 |
| A three-dimensional (3D) bioprinted model of the renal proximal tubule for evaluation of drug-induced nephrotoxicity SM King, TR Smith, JW Higgins, C Nino, AE Chen, SC Presnell, ... Toxicology Letters, S288, 2016 | | 2016 |
