| Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) LJ Sharpe, AJ Brown Journal of Biological Chemistry 288 (26), 18707-18715, 2013 | 395 | 2013 |
| The Akt-SREBP nexus: cell signaling meets lipid metabolism JR Krycer, LJ Sharpe, W Luu, AJ Brown Trends in Endocrinology & Metabolism 21 (5), 268-276, 2010 | 357 | 2010 |
| The E3 Ubiquitin Ligase MARCH6 Degrades Squalene Monooxygenase and Affects 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase and the Cholesterol Synthesis Pathway N Zelcer, LJ Sharpe, A Loregger, I Kristiana, ECL Cook, L Phan, ... Molecular and Cellular Biology 34 (7), 1262-1270, 2014 | 167 | 2014 |
| DHCR7: A vital enzyme switch between cholesterol and vitamin D production AV Prabhu, W Luu, D Li, LJ Sharpe, AJ Brown Progress in Lipid Research 64, 138-151, 2016 | 159 | 2016 |
| Oxysterols: Old Tale, New Twists W Luu, LJ Sharpe, I Capell-Hattam, IC Gelissen, AJ Brown Annual review of pharmacology and toxicology 56, 447-467, 2016 | 139 | 2016 |
| Desmosterol and DHCR24: Unexpected new directions for a terminal step in cholesterol synthesis EJ Zerenturk, LJ Sharpe, E Ikonen, AJ Brown Progress in lipid research 52 (4), 666-680, 2013 | 137 | 2013 |
| Cholesterol-mediated degradation of 7-dehydrocholesterol reductase switches the balance from cholesterol to vitamin D synthesis AV Prabhu, W Luu, LJ Sharpe, AJ Brown Journal of Biological Chemistry 291 (16), 8363-8373, 2016 | 130 | 2016 |
| The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally [S] W Luu, G Hart-Smith, LJ Sharpe, AJ Brown Journal of lipid research 56 (4), 888-897, 2015 | 81 | 2015 |
| The UPS and downs of cholesterol homeostasis LJ Sharpe, ECL Cook, N Zelcer, AJ Brown Trends in biochemical sciences 39 (11), 527-535, 2014 | 78 | 2014 |
| Antipsychotic drugs upregulate lipogenic gene expression by disrupting intracellular trafficking of lipoprotein-derived cholesterol I Kristiana, LJ Sharpe, VS Catts, LH Lutze-Mann, AJ Brown The pharmacogenomics journal 10 (5), 396-407, 2010 | 78 | 2010 |
| New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE, two key control enzymes in cholesterol synthesis V Howe, LJ Sharpe, AV Prabhu, AJ Brown Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2017 | 77 | 2017 |
| Cholesterol homeostasis: How do cells sense sterol excess? V Howe, LJ Sharpe, SJ Alexopoulos, SV Kunze, NK Chua, D Li, AJ Brown Chemistry and physics of lipids 199, 170-178, 2016 | 76 | 2016 |
| Cholesterol synthesis AJ Brown, HW Coates, LJ Sharpe Biochemistry of lipids, lipoproteins and membranes, 317-355, 2021 | 73 | 2021 |
| Akt acutely activates the cholesterogenic transcription factor SREBP-2 W Luu, LJ Sharpe, J Stevenson, AJ Brown Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1823 (2), 458-464, 2012 | 72 | 2012 |
| Akt Phosphorylates Sec24: New Clues into the Regulation of ER‐to‐Golgi Trafficking LJ Sharpe, W Luu, AJ Brown Traffic 12 (1), 19-27, 2011 | 72 | 2011 |
| The role of signalling in cellular cholesterol homeostasis W Luu, LJ Sharpe, IC Gelissen, AJ Brown IUBMB life 65 (8), 675-684, 2013 | 67 | 2013 |
| Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis [S] W Luu, EJ Zerenturk, I Kristiana, MP Bucknall, LJ Sharpe, AJ Brown Journal of lipid research 55 (3), 410-420, 2014 | 65 | 2014 |
| Oxysterols: From physiological tuners to pharmacological opportunities AJ Brown, LJ Sharpe, MJ Rogers British journal of pharmacology 178 (16), 3089-3103, 2021 | 60 | 2021 |
| Diet-induced hypercholesterolemia promotes androgen-independent prostate cancer metastasis via IQGAP1 and caveolin-1 H Moon, JE Ruelcke, E Choi, LJ Sharpe, ZD Nassar, H Bielefeldt-Ohmann, ... Oncotarget 6 (10), 7438-7453, 2015 | 60 | 2015 |
| Sterols regulate 3β-hydroxysterol Δ24-reductase (DHCR24) via dual sterol regulatory elements: Cooperative induction of key enzymes in lipid synthesis by Sterol Regulatory … EJ Zerenturk, LJ Sharpe, AJ Brown Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2012 | 49 | 2012 |
Andrew John BrownProfessor of Biochemistry, University of New South WalesVerified email at unsw.edu.au
