Richard Clark
Richard Clark
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The engineering of an orally active conotoxin for the treatment of neuropathic pain
RJ Clark, J Jensen, ST Nevin, BP Callaghan, DJ Adams, DJ Craik
Angewandte Chemie International Edition 49 (37), 6545-6548, 2010
Engineering stable peptide toxins by means of backbone cyclization: stabilization of the α-conotoxin MII
RJ Clark, H Fischer, L Dempster, NL Daly, KJ Rosengren, ST Nevin, ...
Proceedings of the National Academy of Sciences 102 (39), 13767-13772, 2005
Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone
KJ Rosengren, RJ Clark, NL Daly, U Göransson, A Jones, DJ Craik
Journal of the American Chemical Society 125 (41), 12464-12474, 2003
Engineering stabilized vascular endothelial growth factor-A antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides
S Gunasekera, FM Foley, RJ Clark, L Sando, LJ Fabri, DJ Craik, NL Daly
Journal of medicinal chemistry 51 (24), 7697-7704, 2008
Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds
LY Chan, S Gunasekera, ST Henriques, NF Worth, SJ Le, RJ Clark, ...
Blood, The Journal of the American Society of Hematology 118 (25), 6709-6717, 2011
Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design
RJ Clark, NL Daly, DJ Craik
Biochemical Journal 394 (1), 85-93, 2006
Analgesic α-conotoxins Vc1. 1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation
B Callaghan, A Haythornthwaite, G Berecki, RJ Clark, DJ Craik, ...
Journal of Neuroscience 28 (43), 10943-10951, 2008
Helminth immunomodulation in autoimmune disease
TB Smallwood, PR Giacomin, A Loukas, JP Mulvenna, RJ Clark, JJ Miles
Frontiers in immunology 8, 453, 2017
The synthesis, structural characterization, and receptor specificity of the α-conotoxin Vc1. 1
RJ Clark, H Fischer, ST Nevin, DJ Adams, DJ Craik
Journal of Biological Chemistry 281 (32), 23254-23263, 2006
Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins
JL Dutton, RF Renda, C Waine, RJ Clark, NL Daly, CV Jennings, ...
Journal of Biological Chemistry 279 (45), 46858-46867, 2004
The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity
A Herrmann, R Burman, JS Mylne, G Karlsson, J Gullbo, DJ Craik, ...
Phytochemistry 69 (4), 939-952, 2008
A novel plant protein-disulfide isomerase involved in the oxidative folding of cystine knot defense proteins
CW Gruber, M Cemazar, RJ Clark, T Horibe, RF Renda, MA Anderson, ...
Journal of Biological Chemistry 282 (28), 20435-20446, 2007
Disulfide folding pathways of cystine knot proteins: tying the knot within the circular backbone of the cyclotides
NL Daly, RJ Clark, DJ Craik
Journal of Biological Chemistry 278 (8), 6314-6322, 2003
Linearization of a Naturally Occurring Circular Protein Maintains Structure but Eliminates Hemolytic Activity,
DG Barry, NL Daly, RJ Clark, L Sando, DJ Craik
Biochemistry 42 (22), 6688-6695, 2003
Are α9α10 nicotinic acetylcholine receptors a pain target for α-conotoxins?
ST Nevin, RJ Clark, H Klimis, MJ Christie, DJ Craik, DJ Adams
Molecular pharmacology 72 (6), 1406-1410, 2007
Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif
NL Daly, RJ Clark, MR Plan, DJ Craik
Biochemical Journal 393 (3), 619-626, 2006
The Cyclotide Fingerprint in Oldenlandia affinis: Elucidation of Chemically Modified, Linear and Novel Macrocyclic Peptides
MRR Plan, U Göransson, RJ Clark, NL Daly, ML Colgrave, DJ Craik
ChemBioChem 8 (9), 1001-1011, 2007
Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy
M Akcan, MR Stroud, SJ Hansen, RJ Clark, NL Daly, DJ Craik, JM Olson
Journal of medicinal chemistry 54 (3), 782-787, 2011
Invited reviewnative chemical ligation applied to the synthesis and bioengineering of circular peptides and proteins
RJ Clark, DJ Craik
Peptide Science 94 (4), 414-422, 2010
Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity
YH Huang, ML Colgrave, RJ Clark, AC Kotze, DJ Craik
Journal of Biological Chemistry 285 (14), 10797-10805, 2010
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