Patrick A hughes
Patrick A hughes
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The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli
SM Brierley, PA Hughes, AJ Page, KY Kwan, CM Martin, TA O'Donnell, ...
Gastroenterology 137 (6), 2084-2095. e3, 2009
Selective role for TRPV4 ion channels in visceral sensory pathways
SM Brierley, AJ Page, PA Hughes, B Adam, T Liebregts, NJ Cooper, ...
Gastroenterology 134 (7), 2059-2069, 2008
Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3′, 5′-monophosphate
J Castro, AM Harrington, PA Hughes, CM Martin, P Ge, CM Shea, H Jin, ...
Gastroenterology 145 (6), 1334-1346. e11, 2013
Sensory neuro-immune interactions differ between irritable bowel syndrome subtypes
PA Hughes, AM Harrington, J Castro, T Liebregts, B Adam, DJ Grasby, ...
Gut 62 (10), 1456-1465, 2013
Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses
PA Hughes, SM Brierley, CM Martin, SJH Brookes, DR Linden, ...
Gut 58 (10), 1333-1341, 2009
Effect of fecal microbiota transplantation on 8-week remission in patients with ulcerative colitis: a randomized clinical trial
SP Costello, PA Hughes, O Waters, RV Bryant, AD Vincent, P Blatchford, ...
Jama 321 (2), 156-164, 2019
Immune activation in irritable bowel syndrome: can neuroimmune interactions explain symptoms?
PA Hughes, H Zola, IA Penttila, AL Blackshaw, JM Andrews, ...
American Journal of Gastroenterology 108 (7), 1066-1074, 2013
A novel role for TRPM8 in visceral afferent function
AM Harrington, PA Hughes, CM Martin, J Yang, J Castro, NJ Isaacs, ...
Pain® 152 (7), 1459-1468, 2011
TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity
SM Brierley, J Castro, AM Harrington, PA Hughes, AJ Page, GY Rychkov, ...
The Journal of physiology 589 (14), 3575-3593, 2011
Localization and comparative analysis of acid‐sensing ion channel (ASIC1, 2, and 3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia
PA Hughes, SM Brierley, RL Young, LA Blackshaw
Journal of Comparative Neurology 500 (5), 863-875, 2007
TRP channels: new targets for visceral pain
LA Blackshaw, SM Brierley, PA Hughes
Gut 59 (01), 126-135, 2010
Acid sensing ion channels 2 and 3 are required for inhibition of visceral nociceptors by benzamil
AJ Page, SM Brierley, CM Martin, PA Hughes, LA Blackshaw
PAIN® 133 (1-3), 150-160, 2007
Involvement of metabotropic glutamate 5 receptor in visceral pain
E Lindström, M Brusberg, PA Hughes, CM Martin, SM Brierley, BD Phillis, ...
PAIN® 137 (2), 295-305, 2008
Post‐inflammatory modification of colonic afferent mechanosensitivity
PA Hughes, SM Brierley, LA Blackshaw
Clinical and Experimental Pharmacology and Physiology 36 (10), 1034-1040, 2009
Colonic immune cells in irritable bowel syndrome: A systematic review and meta‐analysis
M Bashashati, S Moossavi, C Cremon, MR Barbaro, S Moraveji, G Talmon, ...
Neurogastroenterology & Motility 30 (1), e13192, 2018
TRPV1-expressing sensory fibres and IBS: links with immune function
PA Hughes, SM Brierley, CM Martin, T Liebregts, J Persson, B Adam, ...
Gut 58 (3), 465-466, 2009
Cognitive-behavioural therapy has no effect on disease activity but improves quality of life in subgroups of patients with inflammatory bowel disease: a pilot randomised …
A Mikocka-Walus, P Bampton, D Hetzel, P Hughes, A Esterman, ...
BMC gastroenterology 15 (1), 54, 2015
Immune derived opioidergic inhibition of viscerosensory afferents is decreased in Irritable Bowel Syndrome patients
PA Hughes, M Moretta, A Lim, DJ Grasby, D Bird, SM Brierley, T Liebregts, ...
Brain, behavior, and immunity 42, 191-203, 2014
Deletion of interleukin-6 signal transducer gp130 in small sensory neurons attenuates mechanonociception and down-regulates TRPA1 expression
P Malsch, M Andratsch, C Vogl, AS Link, C Alzheimer, SM Brierley, ...
Journal of Neuroscience 34 (30), 9845-9856, 2014
Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity
PA Hughes, J Castro, AM Harrington, N Isaacs, M Moretta, GA Hicks, ...
Gut 63 (7), 1199-1200, 2014
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