| The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice SM Solon-Biet, AC McMahon, JWO Ballard, K Ruohonen, LE Wu, ... Cell metabolism 19 (3), 418-430, 2014 | 1005 | 2014 |
| Impairment of an endothelial NAD+-H2S signaling network is a reversible cause of vascular aging A Das, GX Huang, MS Bonkowski, A Longchamp, C Li, MB Schultz, ... Cell 173 (1), 74-89. e20, 2018 | 422 | 2018 |
| IRS1-independent defects define major nodes of insulin resistance KL Hoehn, C Hohnen-Behrens, A Cederberg, LE Wu, N Turner, T Yuasa, ... Cell metabolism 7 (5), 421-433, 2008 | 353 | 2008 |
| NAD+ repletion rescues female fertility during reproductive aging MJ Bertoldo, DR Listijono, WHJ Ho, AH Riepsamen, DM Goss, D Richani, ... Cell reports 30 (6), 1670-1681. e7, 2020 | 257 | 2020 |
| SIRT 2 induces the checkpoint kinase BubR1 to increase lifespan BJ North, MA Rosenberg, KB Jeganathan, AV Hafner, S Michan, J Dai, ... The EMBO journal 33 (13), 1438-1453, 2014 | 247 | 2014 |
| Pigment epithelium-derived factor contributes to insulin resistance in obesity S Crowe, LE Wu, C Economou, SM Turpin, M Matzaris, KL Hoehn, ... Cell metabolism 10 (1), 40-47, 2009 | 222 | 2009 |
| Hepatic fat loss in advanced nonalcoholic steatohepatitis: are alterations in serum adiponectin the cause? D van der Poorten, CF Samer, M Ramezani‐Moghadam, S Coulter, ... Hepatology 57 (6), 2180-2188, 2013 | 183 | 2013 |
| Intrinsic depot-specific differences in the secretome of adipose tissue, preadipocytes, and adipose tissue–derived microvascular endothelial cells SL Hocking, LE Wu, M Guilhaus, DJ Chisholm, DE James Diabetes 59 (12), 3008-3016, 2010 | 138 | 2010 |
| Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity LE Wu, D Samocha-Bonet, PT Whitworth, DJ Fazakerley, N Turner, ... Molecular metabolism 3 (4), 465-473, 2014 | 117 | 2014 |
| Silicon nitride as a versatile growth substrate for microspectroscopic imaging and mapping of individual cells EA Carter, BS Rayner, AI McLeod, LE Wu, CP Marshall, A Levina, ... Molecular Biosystems 6 (7), 1316-1322, 2010 | 91 | 2010 |
| Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency GLM Cagnone, TS Tsai, Y Makanji, P Matthews, J Gould, MS Bonkowski, ... Scientific reports 6 (1), 23229, 2016 | 86 | 2016 |
| Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival ME Nelson, S Lahiri, JDY Chow, FL Byrne, SR Hargett, DS Breen, ... Nature Communications 8 (1), 14689, 2017 | 82 | 2017 |
| Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis LE Wu, AP Gomes, DA Sinclair Cancer cell 25 (1), 12-19, 2014 | 81 | 2014 |
| Carcinogenic chromium (VI) compounds formed by intracellular oxidation of chromium (III) dietary supplements by adipocytes LE Wu, A Levina, HH Harris, Z Cai, B Lai, S Vogt, DE James, PA Lay Angewandte Chemie International Edition 55 (5), 1742-1745, 2016 | 76 | 2016 |
| Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age‐related insulin resistance M Mohamad, SJ Mitchell, LE Wu, MY White, SJ Cordwell, J Mach, ... Aging Cell 15 (4), 706-715, 2016 | 71 | 2016 |
| Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach S Bustamante, T Jayasena, D Richani, RB Gilchrist, LE Wu, DA Sinclair, ... Metabolomics 14, 1-15, 2018 | 67 | 2018 |
| Dynamic acetylation of phosphoenolpyruvate carboxykinase toggles enzyme activity between gluconeogenic and anaplerotic reactions P Latorre-Muro, J Baeza, EA Armstrong, R Hurtado-Guerrero, F Corzana, ... Molecular cell 71 (5), 718-732. e9, 2018 | 65 | 2018 |
| Impairment of an endothelial NAD+-H2S signaling network is a reversible cause of vascular aging A Das, GX Huang, MS Bonkowski, A Longchamp, C Li, MB Schultz, ... Cell 176 (4), 944-945, 2019 | 43 | 2019 |
| Systemic VEGF-A neutralization ameliorates diet-induced metabolic dysfunction LE Wu, CC Meoli, SP Mangiafico, DJ Fazakerley, VC Cogger, ... Diabetes 63 (8), 2656-2667, 2014 | 38 | 2014 |
| Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes A Riepsamen, L Wu, L Lau, D Listijono, W Ledger, D Sinclair, H Homer PLoS One 10 (5), e0126194, 2015 | 36* | 2015 |
David A. SinclairHarvard Medical School (Genetics)Verified email at hms.harvard.edu
