Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function L Chen, SN Willis, A Wei, BJ Smith, JI Fletcher, MG Hinds, PM Colman, ... Molecular cell 17 (3), 393-403, 2005 | 2282 | 2005 |
The B30. 2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1β production JJ Chae, G Wood, SL Masters, K Richard, G Park, BJ Smith, DL Kastner Proceedings of the National Academy of Sciences 103 (26), 9982-9987, 2006 | 755 | 2006 |
Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis PE Czabotar, D Westphal, G Dewson, S Ma, C Hockings, WD Fairlie, ... Cell 152 (3), 519-531, 2013 | 660 | 2013 |
A newly discovered protein export machine in malaria parasites TF de Koning-Ward, PR Gilson, JA Boddey, M Rug, BJ Smith, ... Nature 459 (7249), 945-949, 2009 | 599 | 2009 |
Structural insights into the degradation of Mcl-1 induced by BH3 domains PE Czabotar, EF Lee, MF van Delft, CL Day, BJ Smith, DCS Huang, ... Proceedings of the National Academy of Sciences 104 (15), 6217-6222, 2007 | 519 | 2007 |
How insulin engages its primary binding site on the insulin receptor JG Menting, J Whittaker, MB Margetts, LJ Whittaker, GKW Kong, BJ Smith, ... Nature 493 (7431), 241-245, 2013 | 484 | 2013 |
Structure-guided design of a selective BCL-XL inhibitor G Lessene, PE Czabotar, BE Sleebs, K Zobel, KN Lowes, JM Adams, ... Nature chemical biology 9 (6), 390-397, 2013 | 446 | 2013 |
Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family EF Lee, PE Czabotar, BJ Smith, K Deshayes, K Zobel, PM Colman, ... Cell Death & Differentiation 14 (9), 1711-1713, 2007 | 336 | 2007 |
Discovery of a Potent and Selective BCL-XL Inhibitor with In Vivo Activity ZF Tao, L Hasvold, L Wang, X Wang, AM Petros, CH Park, ER Boghaert, ... ACS medicinal chemistry letters 5 (10), 1088-1093, 2014 | 327 | 2014 |
Assigning absolute values to proton affinities: A differentiation between competing scales BJ Smith, L Radom Journal of the American Chemical Society 115 (11), 4885-4888, 1993 | 300 | 1993 |
The structure of the fusion glycoprotein of Newcastle disease virus suggests a novel paradigm for the molecular mechanism of membrane fusion L Chen, JJ Gorman, J McKimm-Breschkin, LJ Lawrence, PA Tulloch, ... Structure 9 (3), 255-266, 2001 | 289 | 2001 |
Transition structures for the interchange of hydrogen atoms within the water dimer BJ Smith, DJ Swanton, JA Pople, HF Schaefer III, L Radom The Journal of chemical physics 92, 1240, 1990 | 285 | 1990 |
Gaussian‐2 (G2) theory: Reduced basis set requirements LA Curtiss, PC Redfern, BJ Smith, L Radom The Journal of chemical physics 104, 5148, 1996 | 259 | 1996 |
Calculation of proton affinities using the G2 (MP2, SVP) procedure BJ Smith, L Radom The Journal of Physical Chemistry 99 (17), 6468-6471, 1995 | 213 | 1995 |
Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax J Gruszczyk, U Kanjee, LJ Chan, S Menant, B Malleret, NTY Lim, ... Science 359 (6371), 48-55, 2018 | 208 | 2018 |
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis EJ Petrie, JJ Sandow, AV Jacobsen, BJ Smith, MDW Griffin, IS Lucet, ... Nature communications 9 (1), 2422, 2018 | 191 | 2018 |
High‐Resolution Structural Characterization of a Helical α/β‐Peptide Foldamer Bound to the Anti‐Apoptotic Protein Bcl‐xL EF Lee, JD Sadowsky, BJ Smith, PE Czabotar, KJ Peterson‐Kaufman, ... Angewandte Chemie International Edition 48 (24), 4318-4322, 2009 | 187 | 2009 |
Protective hinge in insulin opens to enable its receptor engagement JG Menting, Y Yang, SJ Chan, NB Phillips, BJ Smith, J Whittaker, ... Proceedings of the National Academy of Sciences 111 (33), E3395-E3404, 2014 | 182 | 2014 |
Structural studies of the resistance of influenza virus neuramindase to inhibitors BJ Smith, JL McKimm-Breshkin, M McDonald, RT Fernley, JN Varghese, ... Journal of medicinal chemistry 45 (11), 2207-2212, 2002 | 179 | 2002 |
Evaluation of Diverse α/β Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain MD Boersma, HS Haase, KJ Peterson-Kaufman, EF Lee, OB Clarke, ... Journal of the American Chemical Society, 2012 | 172 | 2012 |