| Interleukin-15 protects from lethal apoptosis in vivo S Bulfone-Paus, D Ungureanu, T Pohl, G Lindner, R Paus, R Rückert, ... Nature medicine 3 (10), 1124-1128, 1997 | 401 | 1997 |
| Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1 D Ungureanu, P Saharinen, I Junttila, DJ Hilton, O Silvennoinen Molecular and cellular biology, 2002 | 363 | 2002 |
| The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling D Ungureanu, J Wu, T Pekkala, Y Niranjan, C Young, ON Jensen, CF Xu, ... Nature structural & molecular biology 18 (9), 971-976, 2011 | 324 | 2011 |
| A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties JM Murphy, Q Zhang, SN Young, ML Reese, FP Bailey, PA Eyers, ... Biochemical Journal 457 (2), 323-334, 2014 | 272 | 2014 |
| Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F RM Bandaranayake, D Ungureanu, Y Shan, DE Shaw, O Silvennoinen, ... Nature structural & molecular biology 19 (8), 754-759, 2012 | 263 | 2012 |
| PIAS proteins promote SUMO-1 conjugation to STAT1 D Ungureanu, S Vanhatupa, N Kotaja, J Yang, S Aittomäki, OA Jänne, ... Blood 102 (9), 3311-3313, 2003 | 215 | 2003 |
| Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase Y Shan, K Gnanasambandan, D Ungureanu, ET Kim, H Hammarén, ... Nature structural & molecular biology 21 (7), 579-584, 2014 | 155 | 2014 |
| SUMO-1 conjugation selectively modulates STAT1-mediated gene responses D Ungureanu, S Vanhatupa, J Grönholm, JJ Palvimo, O Silvennoinen Blood 106 (1), 224-226, 2005 | 129 | 2005 |
| ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation HM Hammarén, D Ungureanu, J Grisouard, RC Skoda, SR Hubbard, ... Proceedings of the National Academy of Sciences 112 (15), 4642-4647, 2015 | 108 | 2015 |
| Structural and functional characterization of the JH2 pseudokinase domain of JAK family tyrosine kinase 2 (TYK2) X Min, D Ungureanu, S Maxwell, H Hammarén, S Thibault, EK Hillert, ... Journal of Biological Chemistry 290 (45), 27261-27270, 2015 | 90 | 2015 |
| Structural insights into pseudokinase domains of receptor tyrosine kinases JB Sheetz, S Mathea, H Karvonen, K Malhotra, D Chatterjee, W Niininen, ... Molecular cell 79 (3), 390-405. e7, 2020 | 66 | 2020 |
| MAPK-induced Ser727 phosphorylation promotes SUMOylation of STAT1 S Vanhatupa, D Ungureanu, M Paakkunainen, O Silvennoinen Biochemical Journal 409 (1), 179-185, 2008 | 55 | 2008 |
| New insights into the structure and function of the pseudokinase domain in JAK2 O Silvennoinen, D Ungureanu, Y Niranjan, H Hammaren, ... Biochemical Society Transactions 41 (4), 1002-1007, 2013 | 53 | 2013 |
| Wnt5a and ROR1 activate non-canonical Wnt signaling via RhoA in TCF3-PBX1 acute lymphoblastic leukemia and highlight new treatment strategies via Bcl-2 co-targeting H Karvonen, R Perttilä, W Niininen, V Hautanen, H Barker, A Murumägi, ... Oncogene 38 (17), 3288-3300, 2019 | 48 | 2019 |
| Glucocorticoids induce differentiation and chemoresistance in ovarian cancer by promoting ROR1-mediated stemness H Karvonen, M Arjama, L Kaleva, W Niininen, H Barker, ... Cell death & disease 11 (9), 790, 2020 | 46 | 2020 |
| Identification and characterization of JAK2 pseudokinase domain small molecule binders DE Puleo, K Kucera, HM Hammarén, D Ungureanu, AS Newton, ... ACS medicinal chemistry letters 8 (6), 618-621, 2017 | 44 | 2017 |
| Molecular mechanisms associated with ROR1-mediated drug resistance: crosstalk with Hippo-YAP/TAZ and BMI-1 pathways H Karvonen, H Barker, L Kaleva, W Niininen, D Ungureanu Cells 8 (8), 812, 2019 | 42 | 2019 |
| Analysis of Jak2 catalytic function by peptide microarrays: the role of the JH2 domain and V617F mutation A Sanz, D Ungureanu, T Pekkala, R Ruijtenbeek, IP Touw, R Hilhorst, ... PloS one 6 (4), e18522, 2011 | 42 | 2011 |
| Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses LN Varghese, D Ungureanu, NPD Liau, SN Young, A Laktyushin, ... Biochemical Journal 458 (2), 395-405, 2014 | 40 | 2014 |
| IL‐15‐IgG2b fusion protein accelerates and enhances a Th2 but not a Th1 immune response in vivo, while IL‐2‐IgG2b fusion protein inhibits both R Rückert, U Herz, R Paus, D Ungureanu, T Pohl, H Renz, ... European journal of immunology 28 (10), 3312-3320, 1998 | 37 | 1998 |
