|Pathological pain and the neuroimmune interface|
PM Grace, MR Hutchinson, SF Maier, LR Watkins
Nature Reviews Immunology 14 (4), 217-231, 2014
|Evidence that opioids may have toll-like receptor 4 and MD-2 effects|
MR Hutchinson, Y Zhang, M Shridhar, JH Evans, MM Buchanan, TX Zhao, ...
Brain, behavior, and immunity 24 (1), 83-95, 2010
|Glia as the “bad guys”: Implications for improving clinical pain control and the clinical utility of opioids|
LR Watkins, MR Hutchinson, A Ledeboer, J Wieseler-Frank, ED Milligan, ...
Brain, behavior, and immunity 21 (2), 131, 2007
|Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward|
MR Hutchinson, ST Bland, KW Johnson, KC Rice, SF Maier, LR Watkins
The Scientific World Journal 7, 98-111, 2007
|The “toll” of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia|
LR Watkins, MR Hutchinson, KC Rice, SF Maier
Trends in pharmacological sciences 30 (11), 581-591, 2009
|Non‐stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll‐like receptor 4 (TLR4)|
MR Hutchinson, Y Zhang, K Brown, BD Coats, M Shridhar, PW Sholar, ...
European Journal of Neuroscience 28 (1), 20-29, 2008
|Glia: novel counter-regulators of opioid analgesia|
LR Watkins, MR Hutchinson, IN Johnston, SF Maier
Trends in neurosciences 28 (12), 661-669, 2005
|Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia|
MR Hutchinson, Y Shavit, PM Grace, KC Rice, SF Maier, LR Watkins
Pharmacological Reviews 63 (3), 772-810, 2011
|Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia|
MR Hutchinson, BD Coats, SS Lewis, Y Zhang, DB Sprunger, N Rezvani, ...
Brain, behavior, and immunity 22 (8), 1178-1189, 2008
|Morphine activates neuroinflammation in a manner parallel to endotoxin|
X Wang, LC Loram, K Ramos, AJ de Jesus, J Thomas, K Cheng, A Reddy, ...
Proceedings of the National Academy of Sciences 109 (16), 6325-6330, 2012
|Toll‐like receptor 4 in CNS pathologies|
MM Buchanan, M Hutchinson, LR Watkins, H Yin
Journal of neurochemistry 114 (1), 13-27, 2010
|Toll-like receptors in chronic pain|
L Nicotra, LC Loram, LR Watkins, MR Hutchinson
Experimental neurology 234 (2), 316-329, 2012
|“Listening” and “talking” to neurons: Implications of immune activation for pain control and increasing the efficacy of opioids|
LR Watkins, MR Hutchinson, ED Milligan, SF Maier
Brain research reviews 56 (1), 148-169, 2007
|Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast)|
MR Hutchinson, SS Lewis, BD Coats, DA Skyba, NY Crysdale, ...
Brain, behavior, and immunity 23 (2), 240-250, 2009
|Opioid activation of toll-like receptor 4 contributes to drug reinforcement|
MR Hutchinson, AL Northcutt, T Hiranita, X Wang, SS Lewis, J Thomas, ...
Journal of Neuroscience 32 (33), 11187-11200, 2012
|Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia|
MR Hutchinson, AL Northcutt, LW Chao, JJ Kearney, Y Zhang, ...
Brain, behavior, and immunity 22 (8), 1248-1256, 2008
|Ibudilast (AV-411) a new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes|
A Ledeboer, MR Hutchinson, LR Watkins, KW Johnson
Expert opinion on investigational drugs 16 (7), 935-950, 2007
|Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1β|
SS Lewis, MR Hutchinson, N Rezvani, LC Loram, Y Zhang, SF Maier, ...
Neuroscience 165 (2), 569-583, 2010
|The cortical innate immune response increases local neuronal excitability leading to seizures|
KM Rodgers, MR Hutchinson, A Northcutt, SF Maier, LR Watkins, ...
Brain 132 (9), 2478-2486, 2009
|Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression|
JM Schwarz, MR Hutchinson, SD Bilbo
Journal of Neuroscience 31 (49), 17835-17847, 2011