Benjamin Porebski
Benjamin Porebski
MRC Laboratory of Molecular Biology
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Cited by
Cited by
The role of protein dynamics in the evolution of new enzyme function
E Campbell, M Kaltenbach, GJ Correy, PD Carr, BT Porebski, ...
Nature chemical biology 12 (11), 944-950, 2016
Consensus protein design
BT Porebski, AM Buckle
Protein Engineering, Design and Selection 29 (7), 245-251, 2016
Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination
DL Burnett, DB Langley, P Schofield, JR Hermes, TD Chan, J Jackson, ...
Science 360 (6385), 223-226, 2018
A synthetic genetic polymer with an uncharged backbone chemistry based on alkyl phosphonate nucleic acids
S Arangundy-Franklin, AI Taylor, BT Porebski, V Genna, S Peak-Chew, ...
Nature chemistry 11 (6), 533-542, 2019
Epitope flexibility and dynamic footprint revealed by molecular dynamics of a pMHC-TCR complex
CF Reboul, GR Meyer, BT Porebski, NA Borg, AM Buckle
PLoS computational biology 8 (3), e1002404, 2012
Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity
NW Zammit, OM Siggs, PE Gray, K Horikawa, DB Langley, SN Walters, ...
Nature immunology 20 (10), 1299-1310, 2019
Modelling of thyroid peroxidase reveals insights into its enzyme function and autoantigenicity
SN Le, BT Porebski, J McCoey, J Fodor, B Riley, M Godlewska, M Gora, ...
PloS one 10 (12), e0142615, 2015
Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity
G Houlihan, S Arangundy-Franklin, BT Porebski, N Subramanian, ...
Nature chemistry 12 (8), 683-690, 2020
Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2
ZE Huma, J Sanchez, HD Lim, JL Bridgford, C Huang, BJ Parker, ...
Science signaling 10 (480), eaai8529, 2017
Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis
I Kass, DE Hoke, MGS Costa, CF Reboul, BT Porebski, NP Cowieson, ...
Proceedings of the National Academy of Sciences 111 (25), E2524-E2529, 2014
Random-sequence genetic oligomer pools display an innate potential for ligation and recombination
H Mutschler, AI Taylor, BT Porebski, A Lightowlers, G Houlihan, ...
Elife 7, e43022, 2018
Structural and dynamic properties that govern the stability of an engineered fibronectin type III domain
BT Porebski, AA Nickson, DE Hoke, MR Hunter, L Zhu, S McGowan, ...
Protein Engineering, Design & Selection 28 (3), 67-78, 2015
Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics
BT Riley, O Ilyichova, MGS Costa, BT Porebski, SJ De Veer, JE Swedberg, ...
Scientific reports 6 (1), 35385, 2016
Reactive centre loop dynamics and serpin specificity
EM Marijanovic, J Fodor, BT Riley, BT Porebski, MGS Costa, I Kass, ...
Scientific reports 9 (1), 3870, 2019
A redundant role of human thyroid peroxidase propeptide for cellular, enzymatic, and immunological activity
M Godlewska, M Góra, AM Buckle, BT Porebski, EH Kemp, BJ Sutton, ...
Thyroid 24 (2), 371-382, 2014
Circumventing the stability-function trade-off in an engineered FN3 domain
BT Porebski, PJ Conroy, N Drinkwater, P Schofield, R Vazquez-Lombardi, ...
Protein Engineering, Design and Selection 29 (11), 541-550, 2016
Structural and dynamic requirements for optimal activity of the essential bacterial enzyme dihydrodipicolinate synthase
CF Reboul, BT Porebski, MDW Griffin, RCJ Dobson, MA Perugini, ...
PLoS computational biology 8 (6), e1002537, 2012
Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens
DL Burnett, P Schofield, DB Langley, J Jackson, K Bourne, E Wilson, ...
Proceedings of the National Academy of Sciences 117 (36), 22341-22350, 2020
Critical evaluation of in silico methods for prediction of coiled-coil domains in proteins
C Li, C Ching Han Chang, J Nagel, BT Porebski, M Hayashida, T Akutsu, ...
Briefings in bioinformatics 17 (2), 270-282, 2016
Smoothing a rugged protein folding landscape by sequence-based redesign
BT Porebski, S Keleher, JJ Hollins, AA Nickson, EM Marijanovic, NA Borg, ...
Scientific Reports 6 (1), 33958, 2016
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