Muharrem Akcan, PhD
Muharrem Akcan, PhD
Kütahya Dumlupınar University, Department of Biochemistry
Verified email at - Homepage
Cited by
Cited by
Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design
J Koehbach, M O’Brien, M Muttenthaler, M Miazzo, M Akcan, AG Elliott, ...
Proceedings of the National Academy of Sciences 110 (52), 21183-21188, 2013
Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy
M Akcan, MR Stroud, SJ Hansen, RJ Clark, NL Daly, DJ Craik, JM Olson
Journal of Medicinal chemistry 54 (3), 782-787, 2011
Cyclization of conotoxins to improve their biopharmaceutical properties
RJ Clark, M Akcan, Q Kaas, NL Daly, DJ Craik
Toxicon 59 (4), 446-455, 2012
Characterization of a Novel Alpha-Conotoxin TxID from Conus textile that Potently Blocks rat Alpha3beta4 Nicotinic Acetylcholine Receptors
S Luo, D Zhangsun, X Zhu, Y Wu, Y Hu, S Christensen, PJ Harvey, ...
Journal of Medicinal Chemistry, 2013
Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition
SJ de Veer, JE Swedberg, M Akcan, KJ Rosengren, M Brattsand, DJ Craik, ...
Biochemical Journal 469 (2), 243-253, 2015
Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro
CI Schroeder, JE Swedberg, JM Withka, KJ Rosengren, M Akcan, ...
Chemistry & biology 21 (2), 284-294, 2014
Characterization of a novel α-conotoxin from conus textile that selectively targets α6/α3β2β3 nicotinic acetylcholine receptors
S Luo, D Zhangsun, Y Wu, X Zhu, Y Hu, M McIntyre, S Christensen, ...
Journal of Biological Chemistry 288 (2), 894-902, 2013
Less is More: Design of a highly stable disulfide-deleted mutant of analgesic cyclic α-conotoxin Vc1. 1
R Yu, VAL Seymour, G Berecki, X Jia, M Akcan, DJ Adams, Q Kaas, ...
Scientific reports 5, 13264, 2015
Synthesis of new thiophene, furan and pyridine substituted 1, 2, 4, 5-oxadiazaboroles
Y Dürüst, M Akcan, O Martiskainen, E Siirola, K Pihlaja
Polyhedron 27 (3), 999-1007, 2008
Transforming conotoxins into cyclotides: Backbone cyclization of P‐superfamily conotoxins
M Akcan, RJ Clark, NL Daly, AC Conibear, A de Faoite, MD Heghinian, ...
Peptide Science 104 (6), 682-692, 2015
Potentiometric Study of Acid− Base Equilibria of 3, 5-Disubstituted 1, 2, 4, 5-Oxadiazaboroles in Nonaqueous Media
Y Dürüst, N Dürüst, M Akcan
Journal of Chemical & Engineering Data 52 (3), 718-720, 2007
Synthesis of cyclic disulfide-rich peptides
M Akcan, DJ Craik
Peptide Synthesis and Applications, 89-101, 2013
Characterization of a novel a-conotoxin from conus textile that selectively targets a6/a3b2b3 nicotinic acetylcholine receptors
S Luo, D Zhangsun, Y Wu, X Zhu, Y Hu, M McIntyre, S Christensen, ...
J. Biol. Chem 288, 894-902, 2013
The three-dimensional solution structure of mini-M conotoxin BtIIIA reveals a disconnection between disulfide connectivity and peptide fold
M Akcan, Y Cao, F Chongxu, DJ Craik
Bioorganic & Medicinal Chemistry, 2013
Engineering venom peptides to improve their stability and bioavailability
M Akcan, DJ Craik
Venoms to Drugs, 275-289, 2015
Correction to Chemical Re-engineering of Chlorotoxin Improves Bioconjugation Properties for Tumor Imaging and Targeted Therapy
M Akcan, MR Stroud, SJ Hansen, RJ Clark, NL Daly, DJ Craik, JM Olson
Journal of Medicinal Chemistry, 2013
Conotoxin‐based leads in drug design
M Akcan, DJ Craik
Peptide Drug Discovery and Development: Translational Research in Academia …, 2011
Disulfide-Rich Peptides in Drug Development
Ş Kara, M Akcan
Hacettepe Journal of Biology and Chemistry 48 (3), 219-229, 2020
Comparative Analysis of the Selected Secondary Metabolites Extracted from Wild and Micropropagated Taraxacum officinale
B Çetin, M Akcan, TE Özen
Journal of Chemical, Biological and Physical Sciences, Section B: Biological …, 2018
Peptide GPCRs as molecular targets for plant cyclotides
J Koehbach, M O'Brien, M Muttenthaler, M Akcan, TJ Smith, DJ Craik, ...
Biopolymers 100 (3), 252-252, 2013
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