| A single administration of CRISPR/Cas9 lipid nanoparticles achieves robust and persistent in vivo genome editing JD Finn, AR Smith, MC Patel, L Shaw, MR Youniss, J van Heteren, ... Cell reports 22 (9), 2227-2235, 2018 | 670 | 2018 |
| Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties LM Wee, CF Flores-Jasso, WE Salomon, PD Zamore Cell 151 (5), 1055-1067, 2012 | 405 | 2012 |
| Single-molecule imaging reveals that argonaute reshapes the binding properties of its nucleic acid guides WE Salomon, SM Jolly, MJ Moore, PD Zamore, V Serebrov Cell 162 (1), 84-95, 2015 | 287 | 2015 |
| Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing JA Broderick, WE Salomon, SP Ryder, N Aronin, PD Zamore Rna 17 (10), 1858-1869, 2011 | 165 | 2011 |
| Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo MR Hassler, AA Turanov, JF Alterman, RA Haraszti, AH Coles, MF Osborn, ... Nucleic acids research 46 (5), 2185-2196, 2018 | 150 | 2018 |
| Reduced size self-delivering RNAi compounds A Khvorova, W Salomon, J Kamens, D Samarsky, TM Woolf, J Cardia US Patent 10,041,073, 2018 | 140* | 2018 |
| Modified RNAi polynucleotides and uses thereof PA Pavco, J Kamens, TM Woolf, W Salomon, A Khvorova US Patent 10,131,904, 2018 | 137* | 2018 |
| Glucan particles for selective delivery of siRNA to phagocytic cells in mice GJ Tesz, M Aouadi, M Prot, SM Nicoloro, E Boutet, SU Amano, A Goller, ... Biochemical Journal 436 (2), 351-362, 2011 | 123 | 2011 |
| RNA interference in skin indications A Khvorova, W Salomon, J Kamens, D Samarsky, TM Woolf, PA Pavco, ... US Patent 8,664,189, 2014 | 70 | 2014 |
| RNA interference in ocular indications L Libertine, A Khvorova, W Salomon, J Kamens, D Samarsky, TM Woolf, ... US Patent 9,095,504, 2015 | 67 | 2015 |
| Rnai constructs and uses thereof D Samarsky, TM Woolf, W Solomon, J Kamens, A Khvorova, PA Pavco US Patent App. 13/055,617, 2011 | 66 | 2011 |
| Tripartite RNAi constructs TM Woolf, PA Pavco, W Salomon, D Samarsky, N Usman, R Wagner US Patent App. 12/286,896, 2009 | 56 | 2009 |
| RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality TM Woolf, J Kamens, W Salomon, A Khvorova US Patent 9,745,574, 2017 | 53 | 2017 |
| Rapid and specific purification of Argonaute-small RNA complexes from crude cell lysates CF Flores-Jasso, WE Salomon, PD Zamore Rna 19 (2), 271-279, 2013 | 53 | 2013 |
| RNA interference in dermal and fibrotic indications A Khvorova, W Salomon, J Kamens, D Samarsky, TM Woolf, PA Pavco, ... US Patent 9,340,786, 2016 | 51* | 2016 |
| Neutral nanotransporters A Khvorova, W Salomon, J Kamens, D Samarsky, TM Woolf, M Miller, ... US Patent 10,138,485, 2018 | 50 | 2018 |
| Inhibition of MAP4K4 through RNAI TM Woolf, J Kamens, A Khvorova, W Salomon US Patent 9,074,211, 2015 | 49 | 2015 |
| RNA interference in skin indications A Khvorova, W Salomon, J Kamens, D Samarsky, TM Woolf, PA Pavco, ... US Patent 9,303,259, 2016 | 43 | 2016 |
| RNA interference in skin indications A Khvorova, W Salomon, J Kamens, D Samarsky, TM Woolf, PA Pavco, ... US Patent 9,938,530, 2018 | 41 | 2018 |
| Reduced size self-delivering RNAI compounds A Khvorova, W Salomon, J Kamens, D Samarsky, TM Woolf, J Cardia US Patent 10,774,330, 2020 | 38 | 2020 |
Phillip D. ZamoreGretchen Stone Cook Professor of Biomedical Sciences, University of Massachusetts Medical SchoolVerified email at umassmed.edu
