| Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice D Edgar, I Shabalina, Y Camara, A Wredenberg, MA Calvaruso, ... Cell metabolism 10 (2), 131-138, 2009 | 286 | 2009 |
| Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice AA Shahmirzadi, D Edgar, CY Liao, YM Hsu, M Lucanic, AA Shahmirzadi, ... Cell metabolism 32 (3), 447-456. e6, 2020 | 238 | 2020 |
| DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity XX Lin, I Sen, GE Janssens, X Zhou, BR Fonslow, D Edgar, N Stroustrup, ... Nature communications 9 (1), 4400, 2018 | 132 | 2018 |
| Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects M Lucanic, WT Plummer, E Chen, J Harke, AC Foulger, B Onken, ... Nature communications 8 (1), 14256, 2017 | 114 | 2017 |
| Altered dopamine metabolism and increased vulnerability to MPTP in mice with partial deficiency of mitochondrial complex I in dopamine neurons FH Sterky, AF Hoffman, D Milenkovic, B Bao, A Paganelli, D Edgar, ... Human molecular genetics 21 (5), 1078-1089, 2012 | 95 | 2012 |
| Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1 IG Shabalina, MY Vyssokikh, N Gibanova, RI Csikasz, D Edgar, ... Aging (Albany NY) 9 (2), 315, 2017 | 92 | 2017 |
| The mtDNA mutator mouse: Dissecting mitochondrial involvement in aging D Edgar, A Trifunovic Aging (Albany NY) 1 (12), 1028, 2009 | 82 | 2009 |
| Loss of UCP2 attenuates mitochondrial dysfunction without altering ROS production and uncoupling activity A Kukat, SA Dogan, D Edgar, A Mourier, C Jacoby, P Maiti, J Mauer, ... PLoS genetics 10 (6), e1004385, 2014 | 80 | 2014 |
| Automated lifespan determination across Caenorhabditis strains and species reveals assay-specific effects of chemical interventions SA Banse, M Lucanic, CA Sedore, AL Coleman-Hulbert, WT Plummer, ... Geroscience 41, 945-960, 2019 | 22 | 2019 |
| Leydig cell steroidogenesis unexpectedly escapes mitochondrial dysfunction in prematurely aging mice IG Shabalina, L Landreh, D Edgar, M Hou, N Gibanova, N Atanassova, ... The FASEB Journal 29 (8), 3274-3286, 2015 | 20 | 2015 |
| Random mtDNA mutations modulate proliferation capacity in mouse embryonic fibroblasts A Kukat, D Edgar, I Bratic, P Maiti, A Trifunovic Biochemical and biophysical research communications 409 (3), 394-399, 2011 | 17 | 2011 |
| Point mutations are causing progeroid phenotypes in the mtDNA mutator mouse D Edgar, NG Larsson, A Trifunovic Cell metabolism 11 (1), 1, 2010 | 11 | 2010 |
| Longitudinal functional study of murine aging: a resource for future study designs DS Evans, MN O'Leary, R Murphy, M Schmidt, K Koenig, M Presley, ... Journal of Bone and Mineral Research Plus 5 (3), e10466, 2021 | 9 | 2021 |
| Standardized Protocols from the Caenorhabditis Intervention Testing Program 2013-2016: conditions and assays used for quantifying the development, fertility and lifespan of … M Lucanic, M Driscoll, WT Plummer, J Harke, E Chen, D Bhaumik, ... | 8 | 2017 |
| Response: point mutations are causing progeroid phenotypes in the mtDNA mutator mouse D Edgar, NG Larsson, A Trifunovic Cell Metabolism 11 (1), 93, 2010 | 5 | 2010 |
| Antioxidants green tea extract and nordihydroguaiaretic acid confer species and strain-specific lifespan and health effects in Caenorhabditis nematodes SA Banse, CA Sedore, E Johnson, AL Coleman-Hulbert, B Onken, D Hall, ... GeroScience 46 (2), 2239-2251, 2024 | 2 | 2024 |
| S10. 25 Effect of targeted quinones on ROS production and lipid peroxidation in mitochondria: Mitochondrial DNA polymerase mutant mice exibit high sensitivity MY Vyssokikh, IG Shabalina, AV Pustovidko, D Edgar, NG Larsson, ... Biochimica et Biophysica Acta (BBA)-Bioenergetics 1777, S64, 2008 | 2 | 2008 |
| Mitochondria: The Dark Side D Edgar, A Trifunovic Role of Physical Exercise in Preventing Disease and Improving the Quality of …, 2007 | 2 | 2007 |
| Formulations for extending lifespan and healthspan B Kennedy, GJ Lithgow, T Weldon, D Edgar, M Lucanic US Patent App. 16/607,855, 2020 | 1 | 2020 |
| Enhanced ROS Production in Mitochondria from Prematurely Aging mtDNA Mutator Mice IG Shabalina, D Edgar, N Gibanova, AV Kalinovich, N Petrovic, ... Biochemistry (Moscow) 89 (2), 279-298, 2024 | | 2024 |
