| Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries H Veith, N Southall, R Huang, T James, D Fayne, N Artemenko, M Shen, ... Nature biotechnology 27 (11), 1050-1055, 2009 | 190 | 2009 |
| Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents NM O’Boyle, M Carr, LM Greene, O Bergin, SM Nathwani, T McCabe, ... Journal of medicinal chemistry 53 (24), 8569-8584, 2010 | 154 | 2010 |
| Advances in the science of estrogen receptor modulation MJ Meegan, DG Lloyd Current medicinal chemistry 10 (3), 181-210, 2003 | 136 | 2003 |
| On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa A Aherne, A Kennan, PF Kenna, N McNally, DG Lloyd, IL Alberts, ... Human molecular genetics 13 (6), 641-650, 2004 | 120 | 2004 |
| Scaffold hopping in de novo design. Ligand generation in the absence of receptor information DG Lloyd, CL Buenemann, NP Todorov, DT Manallack, PM Dean Journal of medicinal chemistry 47 (3), 493-496, 2004 | 100 | 2004 |
| Lead identification of conformationally restricted β-lactam type combretastatin analogues: Synthesis, antiproliferative activity and tubulin targeting effects M Carr, LM Greene, AJS Knox, DG Lloyd, DM Zisterer, MJ Meegan European journal of medicinal chemistry 45 (12), 5752-5766, 2010 | 86 | 2010 |
| Synthesis, evaluation and structural studies of antiproliferative tubulin-targeting azetidin-2-ones NM O’Boyle, LM Greene, O Bergin, JB Fichet, T McCabe, DG Lloyd, ... Bioorganic & medicinal chemistry 19 (7), 2306-2325, 2011 | 85 | 2011 |
| Flexible estrogen receptor modulators: design, synthesis, and antagonistic effects in human MCF-7 breast cancer cells MJ Meegan, RB Hughes, DG Lloyd, DC Williams, DM Zisterer Journal of medicinal chemistry 44 (7), 1072-1084, 2001 | 85 | 2001 |
| Considerations in compound database preparation “Hidden” impact on virtual screening results AJS Knox, MJ Meegan, G Carta, DG Lloyd Journal of chemical information and modeling 45 (6), 1908-1919, 2005 | 83 | 2005 |
| Macrophage Migration Inhibitory Factor (MIF) Enzymatic Activity & Lung Cancer DSC Mawhinney L, Armstrong ME, O' Reilly C, Bucala R, Leng L, Fingerle ... Molecular Medicine 20 (1), 729-735, 2015 | 76* | 2015 |
| Beyond the Ligand‐Binding Pocket: Targeting Alternate Sites in Nuclear Receptors L Caboni, DG Lloyd Medicinal research reviews 33 (5), 1081-1118, 2013 | 75 | 2013 |
| Screening for inhibitors of tau protein aggregation into Alzheimer paired helical filaments: a ligand based approach results in successful scaffold hopping G Larbig, M Pickhardt, DG Lloyd, B Schmidt, E Mandelkow Current Alzheimer Research 4 (3), 315-323, 2007 | 73 | 2007 |
| Oncology exploration: charting cancer medicinal chemistry space DG Lloyd, G Golfis, AJS Knox, D Fayne, MJ Meegan, TI Oprea Drug discovery today 11 (3-4), 149-159, 2006 | 67 | 2006 |
| Unbiasing scoring functions: a new normalization and rescoring strategy G Carta, AJS Knox, DG Lloyd Journal of chemical information and modeling 47 (4), 1564-1571, 2007 | 60 | 2007 |
| Synthesis, biological evaluation, structural–activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators I Barrett, MJ Meegan, RB Hughes, M Carr, AJS Knox, N Artemenko, ... Bioorganic & medicinal chemistry 16 (21), 9554-9573, 2008 | 58 | 2008 |
| Benzoxepin-derived estrogen receptor modulators: a novel molecular scaffold for the estrogen receptor DG Lloyd, RB Hughes, DM Zisterer, DC Williams, C Fattorusso, ... Journal of medicinal chemistry 47 (23), 5612-5615, 2004 | 55 | 2004 |
| “True” Antiandrogens Selective Non-Ligand-Binding Pocket Disruptors of Androgen Receptor–Coactivator Interactions: Novel Tools for Prostate Cancer L Caboni, GK Kinsella, F Blanco, D Fayne, WN Jagoe, M Carr, ... Journal of medicinal chemistry 55 (4), 1635-1644, 2012 | 51 | 2012 |
| Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe NM O’Boyle, M Carr, LM Greene, NO Keely, AJS Knox, T McCabe, ... European journal of medicinal chemistry 46 (9), 4595-4607, 2011 | 51 | 2011 |
| Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe NM O’Boyle, M Carr, LM Greene, NO Keely, AJS Knox, T McCabe, ... European journal of medicinal chemistry 46 (9), 4595-4607, 2011 | 51 | 2011 |
| Murine model of autosomal dominant retinitis pigmentosa generated by targeted deletion at codon 307 of the rds–peripherin gene N McNally, PF Kenna, D Rancourt, T Ahmed, A Stitt, WH Colledge, ... Human Molecular Genetics 11 (9), 1005-1016, 2002 | 51 | 2002 |
