Cynthia Dowd
Cynthia Dowd
Associate Professor, George Washington University
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Cited by
Cited by
PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release
R Singh, U Manjunatha, HIM Boshoff, YH Ha, P Niyomrattanakit, ...
Science 322 (5906), 1392-1395, 2008
Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis
UH Manjunatha, H Boshoff, CS Dowd, L Zhang, TJ Albert, JE Norton, ...
Proceedings of the National Academy of Sciences 103 (2), 431-436, 2006
The role of MmpL8 in sulfatide biogenesis and virulence of Mycobacterium tuberculosis
P Domenech, MB Reed, CS Dowd, C Manca, G Kaplan, CE Barry
Journal of Biological Chemistry 279 (20), 21257-21265, 2004
Biosynthesis and recycling of nicotinamide cofactors in Mycobacterium tuberculosis an essential role for NAD in nonreplicating bacilli
HIM Boshoff, X Xu, K Tahlan, CS Dowd, K Pethe, LR Camacho, TH Park, ...
Journal of Biological Chemistry 283 (28), 19329-19341, 2008
Prospects for clinical introduction of nitroimidazole antibiotics for the treatment of tuberculosis
CE Barry, HIM Boshoff, CS Dowd
Current pharmaceutical design 10 (26), 3239-3262, 2004
B cell signaling is regulated by induced palmitoylation of CD81
A Cherukuri, RH Carter, S Brooks, W Bornmann, R Finn, CS Dowd, ...
Journal of Biological Chemistry 279 (30), 31973-31982, 2004
Structure− activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4-and 5-nitroimidazoles
P Kim, L Zhang, UH Manjunatha, R Singh, S Patel, J Jiricek, TH Keller, ...
Journal of medicinal chemistry 52 (5), 1317-1328, 2009
Structure− Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5 R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium …
P Kim, YM Zhang, G Shenoy, QA Nguyen, HI Boshoff, UH Manjunatha, ...
Journal of medicinal chemistry 49 (1), 159-171, 2006
Structure− activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure− activity relationships
P Kim, S Kang, HI Boshoff, J Jiricek, M Collins, R Singh, UH Manjunatha, ...
Journal of medicinal chemistry 52 (5), 1329-1344, 2009
Substrate specificity of the deazaflavin‐dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic …
M Gurumurthy, T Mukherjee, CS Dowd, R Singh, P Niyomrattanakit, ...
The FEBS journal 279 (1), 113-125, 2012
Synthesis and antitubercular activity of 7-(R)-and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy) benzyloxy)-6, 7-dihydro-5H-imidazo [2, 1-b][1, 3] oxazines, analogues of PA-824
X Li, UH Manjunatha, MB Goodwin, JE Knox, CA Lipinski, TH Keller, ...
Bioorganic & medicinal chemistry letters 18 (7), 2256-2262, 2008
Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs
E Uh, ER Jackson, G San Jose, M Maddox, RE Lee, RE Lee, HI Boshoff, ...
Bioorganic & medicinal chemistry letters 21 (23), 6973-6976, 2011
Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr): a review of the synthesis and biological evaluation of recent inhibitors
E R Jackson, C S Dowd
Current topics in medicinal chemistry 12 (7), 706-728, 2012
Mycobacterium leprae is naturally resistant to PA-824
UH Manjunatha, R Lahiri, B Randhawa, CS Dowd, JL Krahenbuhl, ...
Antimicrobial agents and chemotherapy 50 (10), 3350-3354, 2006
β-Turn Phe in HIV-1 Env binding site of CD4 and CD4 mimetic miniprotein enhances Env binding affinity but is not required for activation of co-receptor/17b site
CS Dowd, S Leavitt, G Babcock, AP Godillot, D Van Ryk, GA Canziani, ...
Biochemistry 41 (22), 7038-7046, 2002
Lipophilic prodrugs of FR900098 are antimicrobial against Francisella novicida in vivo and in vitro and show GlpT independent efficacy
ES McKenney, M Sargent, H Khan, E Uh, ER Jackson, G San Jose, ...
PLoS One 7 (10), e38167, 2012
1-[4-(3-Phenylalkyl)phenyl]-2-aminopropanes as 5-HT2A Partial Agonists
CS Dowd, K Herrick-Davis, C Egan, A DuPre, C Smith, M Teitler, ...
Journal of medicinal chemistry 43 (16), 3074-3084, 2000
Phage randomization in a charybdotoxin scaffold leads to CD4‐mimetic recognition motifs that bind HIV‐1 envelope through non‐aromatic sequences
C Li, CS Dowd, W Zhang, IM Chaiken
The Journal of Peptide Research 57 (6), 507-518, 2001
Synthesis and Bioactivity of β-Substituted Fosmidomycin Analogues Targeting 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase
R Chofor, S Sooriyaarachchi, MDP Risseeuw, T Bergfors, J Pouyez, ...
Journal of medicinal chemistry 58 (7), 2988-3001, 2015
9-Aminoacridine inhibition of HIV-1 Tat dependent transcription
I Guendel, L Carpio, R Easley, R Van Duyne, W Coley, E Agbottah, ...
Virology journal 6 (1), 1-14, 2009
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