| PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release R Singh, U Manjunatha, HIM Boshoff, YH Ha, P Niyomrattanakit, ... Science 322 (5906), 1392-1395, 2008 | 919 | 2008 |
| Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis UH Manjunatha, H Boshoff, CS Dowd, L Zhang, TJ Albert, JE Norton, ... Proceedings of the National Academy of Sciences 103 (2), 431-436, 2006 | 432 | 2006 |
| Biosynthesis and recycling of nicotinamide cofactors in Mycobacterium tuberculosis: an essential role for NAD in nonreplicating bacilli HIM Boshoff, X Xu, K Tahlan, CS Dowd, K Pethe, LR Camacho, TH Park, ... Journal of Biological Chemistry 283 (28), 19329-19341, 2008 | 192 | 2008 |
| The role of MmpL8 in sulfatide biogenesis and virulence of Mycobacterium tuberculosis P Domenech, MB Reed, CS Dowd, C Manca, G Kaplan, CE Barry Journal of Biological Chemistry 279 (20), 21257-21265, 2004 | 181 | 2004 |
| Prospects for clinical introduction of nitroimidazole antibiotics for the treatment of tuberculosis CE Barry, HIM Boshoff, CS Dowd Current pharmaceutical design 10 (26), 3239-3262, 2004 | 165 | 2004 |
| Structure− activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4-and 5-nitroimidazoles P Kim, L Zhang, UH Manjunatha, R Singh, S Patel, J Jiricek, TH Keller, ... Journal of medicinal chemistry 52 (5), 1317-1328, 2009 | 124 | 2009 |
| B cell signaling is regulated by induced palmitoylation of CD81 A Cherukuri, RH Carter, S Brooks, W Bornmann, R Finn, CS Dowd, ... Journal of Biological Chemistry 279 (30), 31973-31982, 2004 | 122 | 2004 |
| Structure− activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure− activity relationships P Kim, S Kang, HI Boshoff, J Jiricek, M Collins, R Singh, UH Manjunatha, ... Journal of medicinal chemistry 52 (5), 1329-1344, 2009 | 105 | 2009 |
| Structure− Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5 R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium … P Kim, YM Zhang, G Shenoy, QA Nguyen, HI Boshoff, UH Manjunatha, ... Journal of medicinal chemistry 49 (1), 159-171, 2006 | 99 | 2006 |
| Substrate specificity of the deazaflavin‐dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic … M Gurumurthy, T Mukherjee, CS Dowd, R Singh, P Niyomrattanakit, ... The FEBS journal 279 (1), 113-125, 2012 | 94 | 2012 |
| Synthesis and antitubercular activity of 7-(R)-and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy) benzyloxy)-6, 7-dihydro-5H-imidazo [2, 1-b][1, 3] oxazines, analogues of PA-824 X Li, UH Manjunatha, MB Goodwin, JE Knox, CA Lipinski, TH Keller, ... Bioorganic & medicinal chemistry letters 18 (7), 2256-2262, 2008 | 78 | 2008 |
| Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs E Uh, ER Jackson, G San Jose, M Maddox, RE Lee, RE Lee, HI Boshoff, ... Bioorganic & medicinal chemistry letters 21 (23), 6973-6976, 2011 | 77 | 2011 |
| Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr): a review of the synthesis and biological evaluation of recent inhibitors E R Jackson, C S Dowd Current topics in medicinal chemistry 12 (7), 706-728, 2012 | 69 | 2012 |
| Phosphonate prodrugs: an overview and recent advances KM Heidel, CS Dowd Future medicinal chemistry 11 (13), 1625-1643, 2019 | 67 | 2019 |
| The methylerythritol phosphate pathway: promising drug targets in the fight against tuberculosis X Wang, CS Dowd ACS infectious diseases 4 (3), 278-290, 2018 | 53 | 2018 |
| Lipophilic Prodrugs of FR900098 Are Antimicrobial against Francisella novicida In Vivo and In Vitro and Show GlpT Independent Efficacy ES McKenney, M Sargent, H Khan, E Uh, ER Jackson, GS Jose, ... Public Library of Science 7 (10), e38167, 2012 | 52 | 2012 |
| Mycobacterium leprae Is Naturally Resistant to PA-824 UH Manjunatha, R Lahiri, B Randhawa, CS Dowd, JL Krahenbuhl, ... Antimicrobial agents and chemotherapy 50 (10), 3350-3354, 2006 | 51 | 2006 |
| Synthesis and Bioactivity of β-Substituted Fosmidomycin Analogues Targeting 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase R Chofor, S Sooriyaarachchi, MDP Risseeuw, T Bergfors, J Pouyez, ... Journal of medicinal chemistry 58 (7), 2988-3001, 2015 | 46 | 2015 |
| 1-[4-(3-Phenylalkyl)phenyl]-2-aminopropanes as 5-HT2A Partial Agonists CS Dowd, K Herrick-Davis, C Egan, A DuPre, C Smith, M Teitler, ... Journal of medicinal chemistry 43 (16), 3074-3084, 2000 | 42 | 2000 |
| Phage randomization in a charybdotoxin scaffold leads to CD4‐mimetic recognition motifs that bind HIV‐1 envelope through non‐aromatic sequences C Li, CS Dowd, W Zhang, IM Chaiken The Journal of Peptide Research 57 (6), 507-518, 2001 | 40 | 2001 |
Clifton E Barry IIINIAIDVerified email at niaid.nih.gov
