Salvatore Valitutti
Salvatore Valitutti
Director of Research at INSERM
Verified email at
Cited by
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Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule
N Holler, R Zaru, O Micheau, M Thome, A Attinger, S Valitutti, JL Bodmer, ...
Nature immunology 1 (6), 489-495, 2000
Serial triggering of many T-cell receptors by a few peptide–MHC complexes
S Valitutti, S Müller, M Cella, E Padovan, A Lanzavecchia
Nature 375 (6527), 148-151, 1995
Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton.
S Valitutti, M Dessing, K Aktories, H Gallati, A Lanzavecchia
The Journal of experimental medicine 181 (2), 577-584, 1995
Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy.
S Valitutti, S Müller, M Dessing, A Lanzavecchia
The Journal of experimental medicine 183 (4), 1917-1921, 1996
CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation
O Gaide, B Favier, DF Legler, D Bonnet, B Brissoni, S Valitutti, C Bron, ...
Nature immunology 3 (9), 836-843, 2002
Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokines.
S Sozzani, F Sallusto, W Luini, D Zhou, L Piemonti, P Allavena, ...
The Journal of Immunology 155 (7), 3292-3295, 1995
Degradation of T cell receptor (TCR)–CD3-ζ complexes after antigenic stimulation
S Valitutti, S Müller, M Salio, A Lanzavecchia
The Journal of experimental medicine 185 (10), 1859-1864, 1997
Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition
S Valitutti, A Lanzavecchia
Immunology today 18 (6), 299-304, 1997
HLA-restricted, processing-and metabolism-independent pathway of drug recognition by human alpha beta T lymphocytes.
MP Zanni, S von Greyerz, B Schnyder, KA Brander, K Frutig, Y Hari, ...
The Journal of clinical investigation 102 (8), 1591-1598, 1998
Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold
M Faroudi, C Utzny, M Salio, V Cerundolo, M Guiraud, S Müller, S Valitutti
Proceedings of the National Academy of Sciences 100 (24), 14145-14150, 2003
A Single Peptide-Major Histocompatibility Complex Ligand Triggers Digital Cytokine Secretion in CD4+ T Cells
J Huang, M Brameshuber, X Zeng, J Xie, Q Li, Y Chien, S Valitutti, ...
Immunity 39 (5), 846-857, 2013
Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes
O Leupin, R Zaru, T Laroche, S Müller, S Valitutti
Current Biology 10 (5), 277-280, 2000
Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8+ T Lymphocytes
W Yu, N Jiang, PJR Ebert, BA Kidd, S Müller, PJ Lund, J Juang, K Adachi, ...
Immunity 42 (5), 929-941, 2015
Immunological synapses are versatile structures enabling selective T cell polarization
D Depoil, R Zaru, M Guiraud, A Chauveau, J Harriague, G Bismuth, ...
Immunity 22 (2), 185-194, 2005
Cytotoxic T lymphocytes kill multiple targets simultaneously via spatiotemporal uncoupling of lytic and stimulatory synapses
A Wiedemann, D Depoil, M Faroudi, S Valitutti
Proceedings of the National Academy of Sciences 103 (29), 10985-10990, 2006
Different activation signals induce distinct mast cell degranulation strategies
N Gaudenzio, R Sibilano, T Marichal, P Starkl, LL Reber, N Cenac, ...
The Journal of clinical investigation 126 (10), 3981-3998, 2016
Normal T lymphocytes can express two different T cell receptor beta chains: implications for the mechanism of allelic exclusion.
E Padovan, C Giachino, M Cella, S Valitutti, O Acuto, A Lanzavecchia
The Journal of experimental medicine 181 (4), 1587-1591, 1995
Cutting edge: T lymphocyte activation by repeated immunological synapse formation and intermittent signaling
M Faroudi, R Zaru, P Paulet, S Müller, S Valitutti
The Journal of Immunology 171 (3), 1128-1132, 2003
The diversity of immunological synapses
A Trautmann, S Valitutti
Current opinion in immunology 15 (3), 249-254, 2003
The efficiency of antigen recognition by CD8+ CTL clones is determined by the frequency of serial TCR engagement
D Hudrisier, B Kessler, S Valitutti, C Horvath, JC Cerottini, IF Luescher
The Journal of Immunology 161 (2), 553-562, 1998
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