An integrated encyclopedia of DNA elements in the human genome ENCODE Project Consortium Nature 489 (7414), 57, 2012 | 11787 | 2012 |
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project ENCODE Project Consortium nature 447 (7146), 799, 2007 | 5321 | 2007 |
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome ND Heintzman, RK Stuart, G Hon, Y Fu, CW Ching, RD Hawkins, ... Nature genetics 39 (3), 311-318, 2007 | 3150 | 2007 |
The accessible chromatin landscape of the human genome RE Thurman, E Rynes, R Humbert, J Vierstra, MT Maurano, E Haugen, ... Nature 489 (7414), 75-82, 2012 | 2379 | 2012 |
Histone modifications at human enhancers reflect global cell-type-specific gene expression ND Heintzman, GC Hon, RD Hawkins, P Kheradpour, A Stark, LF Harp, ... Nature 459 (7243), 108-112, 2009 | 2327 | 2009 |
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers IB Hilton, AM D'ippolito, CM Vockley, PI Thakore, GE Crawford, TE Reddy, ... Nature biotechnology 33 (5), 510-517, 2015 | 1331 | 2015 |
High-resolution mapping and characterization of open chromatin across the genome AP Boyle, S Davis, HP Shulha, P Meltzer, EH Margulies, Z Weng, ... Cell 132 (2), 311-322, 2008 | 1269 | 2008 |
A user's guide to the encyclopedia of DNA elements (ENCODE) ENCODE Project Consortium PLoS biol 9 (4), e1001046, 2011 | 1224 | 2011 |
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression NR Wray, S Ripke, M Mattheisen, M Trzaskowski, EM Byrne, A Abdellaoui, ... Nature genetics 50 (5), 668-681, 2018 | 1191 | 2018 |
RNA-guided gene activation by CRISPR-Cas9–based transcription factors P Perez-Pinera, DD Kocak, CM Vockley, AF Adler, AM Kabadi, ... Nature methods 10 (10), 973-976, 2013 | 1119 | 2013 |
Defining functional DNA elements in the human genome M Kellis, B Wold, MP Snyder, BE Bernstein, A Kundaje, GK Marinov, ... Proceedings of the National Academy of Sciences 111 (17), 6131-6138, 2014 | 657 | 2014 |
DNase I sensitivity QTLs are a major determinant of human expression variation JF Degner, AA Pai, R Pique-Regi, JB Veyrieras, DJ Gaffney, JK Pickrell, ... Nature 482 (7385), 390-394, 2012 | 640 | 2012 |
Dynamic DNA methylation across diverse human cell lines and tissues KE Varley, J Gertz, KM Bowling, SL Parker, TE Reddy, F Pauli-Behn, ... Genome research 23 (3), 555-567, 2013 | 610 | 2013 |
DNase-seq: a high-resolution technique for mapping active gene regulatory elements across the genome from mammalian cells L Song, GE Crawford Cold Spring Harbor Protocols 2010 (2), pdb. prot5384, 2010 | 564 | 2010 |
Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements PI Thakore, AM D'ippolito, L Song, A Safi, NK Shivakumar, AM Kabadi, ... Nature methods 12 (12), 1143-1149, 2015 | 556 | 2015 |
Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity L Song, Z Zhang, LL Grasfeder, AP Boyle, PG Giresi, BK Lee, ... Genome research 21 (10), 1757-1767, 2011 | 524 | 2011 |
Genome-wide mapping of DNase hypersensitive sites using massively parallel signature sequencing (MPSS) GE Crawford, IE Holt, J Whittle, BD Webb, D Tai, S Davis, EH Margulies, ... Genome research 16 (1), 123-131, 2006 | 520 | 2006 |
Retroviral DNA integration: viral and cellular determinants of target-site selection MK Lewinski, M Yamashita, M Emerman, A Ciuffi, H Marshall, G Crawford, ... PLoS pathog 2 (6), e60, 2006 | 422 | 2006 |
F-Seq: a feature density estimator for high-throughput sequence tags AP Boyle, J Guinney, GE Crawford, TS Furey Bioinformatics 24 (21), 2537-2538, 2008 | 402 | 2008 |
Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus W Yang, N Shen, DQ Ye, Q Liu, Y Zhang, XX Qian, N Hirankarn, D Ying, ... PLoS Genet 6 (2), e1000841, 2010 | 397 | 2010 |