| Oncogenic protein interfaces: small molecules, big challenges TL Nero, CJ Morton, JK Holien, J Wielens, MW Parker Nature Reviews Cancer 14 (4), 248-262, 2014 | 363 | 2014 |
| A Systematic and Functional Classification of Streptococcus pyogenes That Serves as a New Tool for Molecular Typing and Vaccine Development M Sanderson-Smith, DMP De Oliveira, J Guglielmini, DJ McMillan, T Vu, ... The Journal of infectious diseases 210 (8), 1325-1338, 2014 | 326 | 2014 |
| Improvements, trends, and new ideas in molecular docking: 2012–2013 in review E Yuriev, J Holien, PA Ramsland Journal of Molecular Recognition 28 (10), 581-604, 2015 | 296 | 2015 |
| Zanamivir-resistant influenza viruses with a novel neuraminidase mutation AC Hurt, JK Holien, M Parker, A Kelso, IG Barr Journal of virology 83 (20), 10366-10373, 2009 | 287 | 2009 |
| Oseltamivir resistance and the H274Y neuraminidase mutation in seasonal, pandemic and highly pathogenic influenza viruses AC Hurt, JK Holien, MW Parker, IG Barr Drugs 69, 2523-2531, 2009 | 164 | 2009 |
| A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production U Nachbur, CA Stafford, A Bankovacki, Y Zhan, LM Lindqvist, BK Fiil, ... Nature communications 6 (1), 6442, 2015 | 135 | 2015 |
| In vitro generation of neuraminidase inhibitor resistance in A (H5N1) influenza viruses AC Hurt, JK Holien, IG Barr Antimicrobial agents and chemotherapy 53 (10), 4433-4440, 2009 | 134 | 2009 |
| Mitochondrial fission–a drug target for cytoprotection or cytodestruction? AA Rosdah, J K. Holien, LMD Delbridge, GJ Dusting, SY Lim Pharmacology research & perspectives 4 (3), e00235, 2016 | 119 | 2016 |
| TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members JL Bell, A Malyukova, JK Holien, J Koach, MW Parker, M Kavallaris, ... PloS one 7 (5), e37470, 2012 | 116 | 2012 |
| Identification and development of specific inhibitors for insulin‐regulated aminopeptidase as a new class of cognitive enhancers AL Albiston, S Diwakarla, RN Fernando, SJ Mountford, HR Yeatman, ... British journal of pharmacology 164 (1), 37-47, 2011 | 111 | 2011 |
| Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor N Etemadi, JK Holien, D Chau, G Dewson, JM Murphy, WS Alexander, ... The FEBS journal 280 (21), 5283-5297, 2013 | 78 | 2013 |
| Crystal structure of human insulin‐regulated aminopeptidase with specificity for cyclic peptides SJ Hermans, DB Ascher, NC Hancock, JK Holien, BJ Michell, SY Chai, ... Protein Science 24 (2), 190-199, 2015 | 70 | 2015 |
| Direct involvement of the TEN domain at the active site of human telomerase J Jurczyluk, AS Nouwens, JK Holien, TE Adams, GO Lovrecz, MW Parker, ... Nucleic acids research 39 (5), 1774-1788, 2011 | 59 | 2011 |
| A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution BP Paudel, AL Moye, H Abou Assi, R El-Khoury, SB Cohen, JK Holien, ... Elife 9, e56428, 2020 | 58 | 2020 |
| Synthesis, structure–activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase SJ Mountford, AL Albiston, WN Charman, L Ng, JK Holien, MW Parker, ... Journal of medicinal chemistry 57 (4), 1368-1377, 2014 | 56 | 2014 |
| Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity SC Feil, S Lawrence, TD Mulhern, JK Holien, EM Hotze, S Farrand, ... Structure 20 (2), 248-258, 2012 | 56 | 2012 |
| New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology AA Rosdah, WJ Smiles, JS Oakhill, JW Scott, CG Langendorf, ... Pharmacology & therapeutics 213, 107594, 2020 | 53 | 2020 |
| Role of nicotinic acetylcholine receptor subunits in the mode of action of neonicotinoid, sulfoximine and spinosyn insecticides in Drosophila melanogaster T Perry, W Chen, R Ghazali, YT Yang, D Christesen, F Martelli, C Lumb, ... Insect Biochemistry and Molecular Biology 131, 103547, 2021 | 50 | 2021 |
| Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission SB Kalkhoran, J Kriston-Vizi, S Hernandez-Resendiz, GE Crespo-Avilan, ... Cardiovascular Research 118 (1), 282-294, 2022 | 49 | 2022 |
| Mechanistic scrutiny identifies a kinetic role for cytochrome b5 regulation of human cytochrome P450c17 (CYP17A1, P450 17A1) AN Simonov, JK Holien, JCI Yeung, AD Nguyen, CJ Corbin, J Zheng, ... PLoS One 10 (11), e0141252, 2015 | 42 | 2015 |
