| Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1. 7 AJ Agwa, N Lawrence, E Deplazes, O Cheneval, RM Chen, DJ Craik, ... Biochimica et Biophysica Acta (BBA)-Biomembranes 1859 (5), 835-844, 2017 | 51 | 2017 |
| Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes AJ Agwa, S Peigneur, CY Chow, N Lawrence, DJ Craik, J Tytgat, GF King, ... Journal of Biological Chemistry 293 (23), 9041-9052, 2018 | 44 | 2018 |
| Lengths of the C-terminus and interconnecting loops impact stability of spider-derived gating modifier toxins AJ Agwa, YH Huang, DJ Craik, ST Henriques, CI Schroeder Toxins 9 (8), 248, 2017 | 29 | 2017 |
| Enzymatic Ligation of a Pore Blocker Toxin and a Gating Modifier Toxin: Creating Double-Knotted Peptides with Improved Sodium Channel NaV1.7 Inhibition HNT Tran, P Tran, JR Deuis, AJ Agwa, AH Zhang, I Vetter, CI Schroeder Bioconjugate Chemistry 31 (1), 64-73, 2019 | 27 | 2019 |
| Efficient enzymatic ligation of inhibitor cystine knot spider venom peptides: Using sortase A to form double-knottins that probe voltage-gated sodium channel NaV1. 7 AJ Agwa, LV Blomster, DJ Craik, GF King, CI Schroeder Bioconjugate Chemistry 29 (10), 3309-3319, 2018 | 24 | 2018 |
| Mapping the Molecular Surface of the Analgesic NaV1.7-Selective Peptide Pn3a Reveals Residues Essential for Membrane and Channel Interactions A Mueller, Z Dekan, Q Kaas, AJ Agwa, H Starobova, PF Alewood, ... ACS Pharmacology & Translational Science 3 (3), 535-546, 2020 | 22 | 2020 |
| Fluorescence Imaging of Peripheral Nerves by a Nav1.7-Targeted Inhibitor Cystine Knot Peptide J Gonzales, P Demetrio de Souza Franca, Y Jiang, G Pirovano, S Kossatz, ... Bioconjugate chemistry 30 (11), 2879-2888, 2019 | 22 | 2019 |
| Gating modifier toxin interactions with ion channels and lipid bilayers: Is the trimolecular complex real? AJ Agwa, ST Henriques, CI Schroeder Neuropharmacology 127, 32-45, 2017 | 21 | 2017 |
| Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7 AJ Agwa, P Tran, A Mueller, HNT Tran, JR Deuis, MR Israel, KL McMahon, ... Journal of Biological Chemistry 295 (15), 5067-5080, 2020 | 20 | 2020 |
| Peptide-membrane interactions affect the inhibitory potency and selectivity of spider toxins ProTx-II and GpTx-1 N Lawrence, B Wu, J Ligutti, O Cheneval, AJ Agwa, AH Benfield, ... ACS chemical biology 14 (1), 118-130, 2018 | 18 | 2018 |
| Pharmacological Inhibition of the Voltage-Gated Sodium Channel NaV1.7 Alleviates Chronic Visceral Pain in a Rodent Model of Irritable Bowel Syndrome Y Jiang, J Castro, LV Blomster, AJ Agwa, J Maddern, G Schober, V Herzig, ... ACS Pharmacology & Translational Science 4 (4), 1362-1378, 2021 | 14 | 2021 |
| Weaponisation ‘on the fly’: Convergent recruitment of knottin and defensin peptide scaffolds into the venom of predatory assassin flies J Jin, AJ Agwa, TG Szanto, A Csóti, G Panyi, CI Schroeder, AA Walker, ... Insect biochemistry and molecular biology 118, 103310, 2020 | 12 | 2020 |
| Multipurpose peptides: the venoms of Amazonian stinging ants contain anthelmintic ponericins with diverse predatory and defensive activities SA Nixon, SD Robinson, AJ Agwa, AA Walker, S Choudhary, A Touchard, ... Biochemical pharmacology 192, 114693, 2021 | 11 | 2021 |
| Cyclizing disulfide-rich peptides using sortase A AJ Agwa, DJ Craik, CI Schroeder Enzyme-Mediated Ligation Methods, 29-41, 2019 | 6 | 2019 |
| Discovery and characterisation of novel peptides from Amazonian stinging ant venoms with antiparasitic activity S Nixon, A Agwa, S Robinson, A Walker, A Touchard, C Schroeder, ... Toxicon 177, S60-S60, 2020 | 1 | 2020 |
| Corrigendum to" Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1. 7"[Biochim … AJ Agwa, N Lawrence, E Deplazes, O Cheneval, RM Chen, DJ Craik, ... Biochimica et biophysica acta. Biomembranes 1859 (11), 2277, 2017 | 1 | 2017 |
| The tri-molecular concept: exploiting the lipid membrane in the design of potent and selective inhibitors for voltage-gated sodium channels JA Agwa | | 2019 |
| The Use of Peptide-Membrane Interactions in the Design of Selective and Potent Sodium Channel Inhibitors C Schroeder, A Agwa, A Mueller, CY Chow, S Peigneur, N Lawrence, ... Journal Of Peptide Science 24, S70-S70, 2018 | | 2018 |
| The Importance of Peptide-Membrane Interactions in Toxin Inhibitions of Sodium Channels CI Schroeder, E Deplazes, N Lawrence, A Agwa, ST Henriques Biophysical Journal 112 (3), 226a, 2017 | | 2017 |
| B) Manipulating the pharmacophore of HwTx-IV to influence affinity for lipid bilayers, and in vitro selectivity for NaV1. 7 AJ Agwa, A Mueller, MR Israel, P Tran, DJ Craik, I Vetter, CI Schroeder The tri-molecular concept: exploiting the lipid membrane in the design of …, 0 | | |
