| Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension CD Cox, C Bae, L Ziegler, S Hartley, V Nikolova-Krstevski, PR Rohde, ... Nature communications 7 (1), 10366, 2016 | 508 | 2016 |
| The N–terminal tail of hERG contains an amphipathic α–helix that regulates channel deactivation CA Ng, MJ Hunter, MD Perry, M Mobli, Y Ke, PW Kuchel, GF King, D Stock, ... PloS one 6 (1), e16191, 2011 | 108 | 2011 |
| High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants CA Ng, MD Perry, W Liang, NJ Smith, B Foo, A Shrier, GL Lukacs, AP Hill, ... Heart rhythm 17 (3), 492-500, 2020 | 65 | 2020 |
| The S4–S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating CA Ng, MD Perry, PS Tan, AP Hill, PW Kuchel, JI Vandenberg PloS one 7 (2), e31640, 2012 | 58 | 2012 |
| Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels PS Tan, MD Perry, CA Ng, JI Vandenberg, AP Hill Journal of General Physiology 140 (3), 293-306, 2012 | 54 | 2012 |
| High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11. 1 KA Kozek, AM Glazer, CA Ng, D Blackwell, CL Egly, LR Vanags, M Blair, ... Heart rhythm 17 (12), 2180-2189, 2020 | 53 | 2020 |
| Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11. 1 channels CA Ng, K Phan, AP Hill, JI Vandenberg, MD Perry Journal of Biological Chemistry 289 (37), 25822-25832, 2014 | 53 | 2014 |
| Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2 A Sadrieh, L Domanski, J Pitt-Francis, SA Mann, EC Hodkinson, CA Ng, ... Nature communications 5 (1), 5069, 2014 | 52 | 2014 |
| Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain–domain interactions Y Ke, CA Ng, MJ Hunter, SA Mann, J Heide, AP Hill, JI Vandenberg Biochemical Journal 454 (1), 69-77, 2013 | 47 | 2013 |
| Getting to the heart of hERG K+ channel gating MD Perry, CA Ng, SA Mann, A Sadrieh, M Imtiaz, AP Hill, JI Vandenberg The Journal of physiology 593 (12), 2575-2585, 2015 | 43 | 2015 |
| Rescue of protein expression defects may not be enough to abolish the pro‐arrhythmic phenotype of long QT type 2 mutations MD Perry, CA Ng, K Phan, E David, K Steer, MJ Hunter, SA Mann, ... The Journal of physiology 594 (14), 4031-4049, 2016 | 37 | 2016 |
| Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization MD Perry, CA Ng, MM Mangala, TYM Ng, AD Hines, W Liang, MJO Xu, ... Cardiovascular research 116 (8), 1434-1445, 2020 | 33 | 2020 |
| Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations JV Li, CA Ng, D Cheng, Z Zhou, M Yao, Y Guo, ZY Yu, Y Ramaswamy, ... Communications Biology 4 (1), 1038, 2021 | 26 | 2021 |
| Role of the cytoplasmic N-terminal Cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11. 1 channels Y Ke, MJ Hunter, CA Ng, MD Perry, JI Vandenberg Journal of Biological Chemistry 289 (20), 13782-13791, 2014 | 26 | 2014 |
| A massively parallel assay accurately discriminates between functionally normal and abnormal variants in a hotspot domain of KCNH2 CA Ng, R Ullah, J Farr, AP Hill, KA Kozek, LR Vanags, DW Mitchell, ... The American Journal of Human Genetics 109 (7), 1208-1216, 2022 | 23 | 2022 |
| Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11. 1 channels MD Perry, S Wong, CA Ng, JI Vandenberg Journal of General Physiology 142 (3), 275-288, 2013 | 22 | 2013 |
| Pore helices play a dynamic role as integrators of domain motion during Kv11. 1 channel inactivation gating MD Perry, CA Ng, JI Vandenberg Journal of Biological Chemistry 288 (16), 11482-11491, 2013 | 22 | 2013 |
| A calibrated functional patch-clamp assay to enhance clinical variant interpretation in KCNH2-related long QT syndrome C Jiang, E Richardson, J Farr, AP Hill, R Ullah, BM Kroncke, SM Harrison, ... The American Journal of Human Genetics 109 (7), 1199-1207, 2022 | 19 | 2022 |
| Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology CA Ng, J Farr, P Young, MJ Windley, MD Perry, AP Hill, JI Vandenberg Biology Methods and Protocols 6 (1), bpab003, 2021 | 14 | 2021 |
| Insights into hERG K+ channel structure and function from NMR studies CA Ng, AM Torres, G Pages, PW Kuchel, JI Vandenberg European Biophysics Journal 42, 71-79, 2013 | 14 | 2013 |
Jamie VandenbergProfessor, Victor Chang Cardiac Research InstituteVerified email at victorchang.edu.au
