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Chai Ann Ng
Chai Ann Ng
Verified email at victorchang.edu.au
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Cited by
Year
Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension
CD Cox, C Bae, L Ziegler, S Hartley, V Nikolova-Krstevski, PR Rohde, ...
Nature communications 7 (1), 10366, 2016
4672016
The N–terminal tail of hERG contains an amphipathic α–helix that regulates channel deactivation
CA Ng, MJ Hunter, MD Perry, M Mobli, Y Ke, PW Kuchel, GF King, D Stock, ...
PloS one 6 (1), e16191, 2011
1072011
The S4–S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating
CA Ng, MD Perry, PS Tan, AP Hill, PW Kuchel, JI Vandenberg
PloS one 7 (2), e31640, 2012
582012
High-throughput phenotyping of heteromeric human ether-a-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants
CA Ng, MD Perry, W Liang, NJ Smith, B Foo, A Shrier, GL Lukacs, AP Hill, ...
Heart rhythm 17 (3), 492-500, 2020
562020
Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11. 1 channels
CA Ng, K Phan, AP Hill, JI Vandenberg, MD Perry
Journal of Biological Chemistry 289 (37), 25822-25832, 2014
562014
Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels
PS Tan, MD Perry, CA Ng, JI Vandenberg, AP Hill
Journal of General Physiology 140 (3), 293-306, 2012
542012
Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2
A Sadrieh, L Domanski, J Pitt-Francis, SA Mann, EC Hodkinson, CA Ng, ...
Nature communications 5 (1), 5069, 2014
492014
Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain–domain interactions
Y Ke, CA Ng, MJ Hunter, SA Mann, J Heide, AP Hill, JI Vandenberg
Biochemical Journal 454 (1), 69-77, 2013
472013
High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11. 1
KA Kozek, AM Glazer, CA Ng, D Blackwell, CL Egly, LR Vanags, M Blair, ...
Heart rhythm 17 (12), 2180-2189, 2020
432020
Getting to the heart of hERG K+ channel gating
MD Perry, CA Ng, SA Mann, A Sadrieh, M Imtiaz, AP Hill, JI Vandenberg
The Journal of physiology 593 (12), 2575-2585, 2015
422015
Rescue of protein expression defects may not be enough to abolish the pro‐arrhythmic phenotype of long QT type 2 mutations
MD Perry, CA Ng, K Phan, E David, K Steer, MJ Hunter, SA Mann, ...
The Journal of physiology 594 (14), 4031-4049, 2016
342016
Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization
MD Perry, CA Ng, MM Mangala, TYM Ng, AD Hines, W Liang, MJO Xu, ...
Cardiovascular research 116 (8), 1434-1445, 2020
292020
Role of the cytoplasmic N-terminal Cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11. 1 channels
Y Ke, MJ Hunter, CA Ng, MD Perry, JI Vandenberg
Journal of Biological Chemistry 289 (20), 13782-13791, 2014
262014
Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations
JV Li, CA Ng, D Cheng, Z Zhou, M Yao, Y Guo, ZY Yu, Y Ramaswamy, ...
Communications Biology 4 (1), 1038, 2021
232021
Pore helices play a dynamic role as integrators of domain motion during Kv11. 1 channel inactivation gating
MD Perry, CA Ng, JI Vandenberg
Journal of Biological Chemistry 288 (16), 11482-11491, 2013
222013
Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11. 1 channels
MD Perry, S Wong, CA Ng, JI Vandenberg
Journal of General Physiology 142 (3), 275-288, 2013
212013
A massively parallel assay accurately discriminates between functionally normal and abnormal variants in a hotspot domain of KCNH2
CA Ng, R Ullah, J Farr, AP Hill, KA Kozek, LR Vanags, DW Mitchell, ...
The American Journal of Human Genetics 109 (7), 1208-1216, 2022
172022
Insights into hERG K+ channel structure and function from NMR studies
CA Ng, AM Torres, G Pages, PW Kuchel, JI Vandenberg
European Biophysics Journal 42, 71-79, 2013
142013
A calibrated functional patch-clamp assay to enhance clinical variant interpretation in KCNH2-related long QT syndrome
C Jiang, E Richardson, J Farr, AP Hill, R Ullah, BM Kroncke, SM Harrison, ...
The American Journal of Human Genetics 109 (7), 1199-1207, 2022
132022
Structural characterisation of PinA WW domain and a comparison with other group IV WW domains, Pin1 and Ess1
CA Ng, Y Kato, M Tanokura, RTC Brownlee
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1784 (9), 1208-1214, 2008
132008
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