| Increased expression of the amyloid precursor β‐secretase in Alzheimer's disease RMD Holsinger, CA McLean, K Beyreuther, CL Masters, G Evin Annals of neurology: Official journal of the American neurological …, 2002 | 688 | 2002 |
| Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease RMD Holsinger, J Schnarr, P Henry, VT Castelo, M Fahnestock Molecular Brain Research 76 (2), 347-354, 2000 | 412 | 2000 |
| Degradation of the Alzheimer disease amyloid β-peptide by metal-dependent up-regulation of metalloprotease activity AR White, T Du, KM Laughton, I Volitakis, RA Sharples, ME Xilinas, ... Journal of Biological Chemistry 281 (26), 17670-17680, 2006 | 350 | 2006 |
| Saxagliptin: a dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease J Kosaraju, CC Gali, RB Khatwal, A Dubala, S Chinni, RMD Holsinger, ... Neuropharmacology 72, 291-300, 2013 | 195 | 2013 |
| Neurotrophic factors and Alzheimer’s disease: are we focusing on the wrong molecule? M Fahnestock, D Garzon, RMD Holsinger, B Michalski Ageing and Dementia Current and Future Concepts, 241-252, 2002 | 188 | 2002 |
| Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets G Evin, A Zhu, RMD Holsinger, CL Masters, QX Li Journal of neuroscience research 74 (3), 386-392, 2003 | 174 | 2003 |
| Exercise-induced brain-derived neurotrophic factor expression: Therapeutic implications for Alzheimer’s dementia R Wang, RMD Holsinger Ageing research reviews 48, 109-121, 2018 | 160 | 2018 |
| Lesions of the medial or lateral perforant path have different effects on hippocampal contributions to place learning and on fear conditioning to context J Ferbinteanu, RMD Holsinger, RJ McDonald Behavioural brain research 101 (1), 65-84, 1999 | 138 | 1999 |
| Increased β‐Secretase activity in cerebrospinal fluid of Alzheimer's disease subjects RMD Holsinger, CA McLean, SJ Collins, CL Masters, G Evin Annals of Neurology: Official Journal of the American Neurological …, 2004 | 125 | 2004 |
| APP intracellular domain is increased and soluble Aβ is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease AJ George, RMD Holsinger, CA McLean, KM Laughton, K Beyreuther, ... Neurobiology of disease 16 (1), 124-132, 2004 | 125 | 2004 |
| Identification of molecular signatures and pathways to identify novel therapeutic targets in Alzheimer's disease: Insights from a systems biomedicine perspective MR Rahman, T Islam, T Zaman, M Shahjaman, MR Karim, F Huq, ... Genomics 112 (2), 1290-1299, 2020 | 122 | 2020 |
| Linagliptin, a dipeptidyl peptidase-4 inhibitor, mitigates cognitive deficits and pathology in the 3xTg-AD mouse model of Alzheimer’s disease J Kosaraju, RMD Holsinger, L Guo, KY Tam Molecular Neurobiology 54, 6074-6084, 2017 | 103 | 2017 |
| CSF BACE1 activity is increased in CJD and Alzheimer disease versus other dementias RMD Holsinger, JS Lee, A Boyd, CL Masters, SJ Collins Neurology 67 (4), 710-712, 2006 | 95 | 2006 |
| Decreased phosphatidylethanolamine binding protein expression correlates with Aβ accumulation in the Tg2576 mouse model of Alzheimer's disease AJ George, RMD Holsinger, CA McLean, SS Tan, HS Scott, T Cardamone, ... Neurobiology of aging 27 (4), 614-623, 2006 | 94 | 2006 |
| Development of spontaneous seizures over extended electrical kindling: I. Electrographic, behavioral, and transfer kindling correlates M Michael, D Holsinger, C Ikeda-Douglas, S Cammisuli, J Ferbinteanu, ... Brain research 793 (1-2), 197-211, 1998 | 90 | 1998 |
| Oxidative stress and antioxidants in neurodegenerative disorders EO Olufunmilayo, MB Gerke-Duncan, RMD Holsinger Antioxidants 12 (2), 517, 2023 | 77 | 2023 |
| A serial analysis of gene expression profile of the Alzheimer’s disease Tg2576 mouse model AJ George, L Gordon, T Beissbarth, I Koukoulas, RMD Holsinger, ... Neurotoxicity research 17, 360-379, 2010 | 64 | 2010 |
| Heparin activates β-secretase (BACE1) of Alzheimer's disease and increases autocatalysis of the enzyme M Beckman, RMD Holsinger, DH Small Biochemistry 45 (21), 6703-6714, 2006 | 60 | 2006 |
| Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease G Evin, RA Sharples, A Weidemann, FBM Reinhard, V Carbone, ... Biochemistry 40 (28), 8359-8368, 2001 | 52 | 2001 |
| Effects of extended electrical kindling on exploratory behavior and spatial learning S Cammisuli, MP Murphy, CJ Ikeda-Douglas, V Balkissoon, ... Behavioural brain research 89 (1-2), 179-190, 1997 | 40 | 1997 |
