Constantinos Koumenis
Constantinos Koumenis
Department of Radiation Oncology, University of Pennsylvania School of Medicine
Verified email at
Cited by
Cited by
Guidelines for the use and interpretation of assays for monitoring autophagy
DJ Klionsky, K Abdelmohsen, A Abe, MJ Abedin, H Abeliovich, ...
Autophagy 12 (1), 1-222, 2016
ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
M Bi, C Naczki, M Koritzinsky, D Fels, J Blais, N Hu, H Harding, I Novoa, ...
The EMBO journal 24 (19), 3470-3481, 2005
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2α
C Koumenis, C Naczki, M Koritzinsky, S Rastani, A Diehl, N Sonenberg, ...
Molecular and cellular biology 22 (21), 7405-7416, 2002
Activating transcription factor 4 is translationally regulated by hypoxic stress
JD Blais, V Filipenko, M Bi, HP Harding, D Ron, C Koumenis, BG Wouters, ...
Molecular and cellular biology 24 (17), 7469-7482, 2004
The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation
J Ye, M Kumanova, LS Hart, K Sloane, H Zhang, DN De Panis, ...
The EMBO journal 29 (12), 2082-2096, 2010
Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation
C Koumenis, R Alarcon, E Hammond, P Sutphin, W Hoffman, M Murphy, ...
Molecular and cellular biology 21 (4), 1297-1310, 2001
The PERK/eIF2α/ATF4 module of the UPR in hypoxia resistance and tumor growth
DR Fels, C Koumenis
Cancer biology & therapy 5 (7), 723-728, 2006
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control
M Koritzinsky, MG Magagnin, T van den Beucken, R Seigneuric, ...
The EMBO journal 25 (5), 1114-1125, 2006
Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress
JD Blais, CL Addison, R Edge, T Falls, H Zhao, K Wary, C Koumenis, ...
Molecular and cellular biology 26 (24), 9517-9532, 2006
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3β
LK Qu, S Huang, D Baltzis, AM Rivas-Estilla, O Pluquet, M Hatzoglou, ...
Genes & development 18 (3), 261-277, 2004
Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma
XH Ma, SF Piao, S Dey, Q Mcafee, G Karakousis, J Villanueva, LS Hart, ...
The Journal of clinical investigation 124 (3), 1406-1417, 2014
ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth
LS Hart, JT Cunningham, T Datta, S Dey, F Tameire, SL Lehman, B Qiu, ...
The Journal of clinical investigation 122 (12), 4621-4634, 2012
ER stress, hypoxia tolerance and tumor progression
C Koumenis
Current molecular medicine 6 (1), 55-69, 2006
“Translating” Tumor Hypoxia: Unfolded Protein Response (UPR)–Dependent and UPR-Independent Pathways
C Koumenis, BG Wouters
Molecular Cancer Research 4 (7), 423-436, 2006
PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage
E Bobrovnikova-Marjon, C Grigoriadou, D Pytel, F Zhang, J Ye, ...
Oncogene 29 (27), 3881-3895, 2010
Control of the hypoxic response through regulation of mRNA translation
BG Wouters, T van den Beucken, MG Magagnin, M Koritzinsky, D Fels, ...
Seminars in cell & developmental biology 16 (4-5), 487-501, 2005
Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation
R Alarcón, C Koumenis, RK Geyer, CG Maki, AJ Giaccia
Cancer research 59 (24), 6046-6051, 1999
Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells
JL Little, FB Wheeler, DR Fels, C Koumenis, SJ Kridel
Cancer research 67 (3), 1262-1269, 2007
The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen …
P Javvadi, AT Segan, SW Tuttle, C Koumenis
Molecular pharmacology 73 (5), 1491-1501, 2008
miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner
NS Chitnis, D Pytel, E Bobrovnikova-Marjon, D Pant, H Zheng, NL Maas, ...
Molecular cell 48 (3), 353-364, 2012
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