Christopher R. Horne
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Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis
SE Garnish, Y Meng, A Koide, JJ Sandow, E Denbaum, AV Jacobsen, ...
Nature communications 12 (1), 2211, 2021
Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis
Y Meng, KA Davies, C Fitzgibbon, SN Young, SE Garnish, CR Horne, ...
Nature Communications 12 (1), 6783, 2021
A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells
AL Samson, C Fitzgibbon, KM Patel, JM Hildebrand, LW Whitehead, ...
Cell Death & Differentiation 28 (7), 2126-2144, 2021
“Just a spoonful of sugar...”: import of sialic acid across bacterial cell membranes
RA North, CR Horne, JS Davies, DM Remus, AC Muscroft-Taylor, P Goyal, ...
Biophysical Reviews 10, 219-227, 2018
Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL
A Sethi, CR Horne, C Fitzgibbon, K Wilde, KA Davies, SE Garnish, ...
Cell Death & Differentiation 29 (9), 1804-1815, 2022
The web of death: the expanding complexity of necroptotic signaling
CR Horne, AL Samson, JM Murphy
Trends in Cell Biology 33 (2), 162-174, 2023
Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism
CR Horne, H Venugopal, S Panjikar, DM Wood, A Henrickson, E Brookes, ...
Nature communications 12 (1), 1988, 2021
Functional and solution structure studies of amino sugar deacetylase and deaminase enzymes from Staphylococcus aureus
JS Davies, D Coombes, CR Horne, FG Pearce, R Friemann, RA North, ...
FEBS letters 593 (1), 52-66, 2019
Modifying the resolving cysteine affects the structure and hydrogen peroxide reactivity of peroxiredoxin 2
AV Peskin, FC Meotti, KM Kean, C Göbl, AS Peixoto, PE Pace, CR Horne, ...
Journal of Biological Chemistry 296, 2021
On the structure and function of Escherichia coli YjhC: An oxidoreductase involved in bacterial sialic acid metabolism
CR Horne, L Kind, JS Davies, RCJ Dobson
Proteins: Structure, Function, and Bioinformatics 88 (5), 654-668, 2020
The basis for non-canonical ROK family function in the N-acetylmannosamine kinase from the pathogen Staphylococcus aureus
D Coombes, JS Davies, MC Newton-Vesty, CR Horne, TG Setty, ...
Journal of Biological Chemistry 295 (10), 3301-3315, 2020
Multi-wavelength analytical ultracentrifugation as a tool to characterise protein–DNA interactions in solution
CR Horne, A Henrickson, B Demeler, RCJ Dobson
European Biophysics Journal 49 (8), 819-827, 2020
Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker
BC Lechtenberg, MP Gehring, TP Light, CR Horne, MW Matsumoto, ...
Nature communications 12 (1), 7047, 2021
Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling
Y Meng, CR Horne, AL Samson, LF Dagley, SN Young, JJ Sandow, ...
Cell Death & Disease 13 (6), 565, 2022
The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs
LY Liang, M Roy, CR Horne, JJ Sandow, M Surudoi, LF Dagley, ...
Biochemical Journal 478 (17), 3351-3371, 2021
Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix
MR Oliver, CR Horne, S Shrestha, JR Keown, LY Liang, SN Young, ...
Nature Communications 12 (1), 1002, 2021
Using cryo-EM to uncover mechanisms of bacterial transcriptional regulation
DM Wood, RCJ Dobson, CR Horne
Biochemical Society Transactions 49 (6), 2711-2726, 2021
N-acetylmannosamine-6-phosphate 2-epimerase uses a novel substrate-assisted mechanism to catalyze amino sugar epimerization
MJ Currie, L Manjunath, CR Horne, PM Rendle, R Subramanian, ...
Journal of Biological Chemistry 297 (4), 2021
A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation
SE Garnish, KR Martin, M Kauppi, VE Jackson, R Ambrose, VV Eng, ...
Nature Communications 14 (1), 6046, 2023
Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL
T Sadras, FB Jalud, HJ Kosasih, CR Horne, LM Brown, S El-Kamand, ...
Leukemia 37 (4), 905-909, 2023
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