Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repair AM Fleming, Y Ding, CJ Burrows Proceedings of the National Academy of Sciences 114 (10), 2604-2609, 2017 | 362 | 2017 |
Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution V Khoddami, A Yerra, TL Mosbruger, AM Fleming, CJ Burrows, BR Cairns Proceedings of the National Academy of Sciences 116 (14), 6784-6789, 2019 | 213 | 2019 |
Sequencing the mouse genome for the oxidatively modified base 8-oxo-7, 8-dihydroguanine by OG-Seq Y Ding, AM Fleming, CJ Burrows Journal of the American Chemical Society 139 (7), 2569-2572, 2017 | 167 | 2017 |
The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures J Zhou, AM Fleming, AM Averill, CJ Burrows, SS Wallace Nucleic acids research 43 (8), 4039-4054, 2015 | 166 | 2015 |
G-quadruplex folds of the human telomere sequence alter the site reactivity and reaction pathway of guanine oxidation compared to duplex DNA AM Fleming, CJ Burrows Chemical research in toxicology 26 (4), 593-607, 2013 | 154 | 2013 |
A role for the fifth G-track in G-quadruplex forming oncogene promoter sequences during oxidative stress: Do these “spare tires” have an evolved function? AM Fleming, J Zhou, SS Wallace, CJ Burrows ACS central science 1 (5), 226-233, 2015 | 141 | 2015 |
8-Oxo-7, 8-dihydroguanine, friend and foe: Epigenetic-like regulator versus initiator of mutagenesis AM Fleming, CJ Burrows DNA repair 56, 75-83, 2017 | 139 | 2017 |
Neil3 and NEIL1 DNA glycosylases remove oxidative damages from quadruplex DNA and exhibit preferences for lesions in the telomeric sequence context J Zhou, M Liu, AM Fleming, CJ Burrows, SS Wallace Journal of Biological Chemistry 288 (38), 27263-27272, 2013 | 136 | 2013 |
Zika virus genomic RNA possesses conserved G-quadruplexes characteristic of the flaviviridae family AM Fleming, Y Ding, A Alenko, CJ Burrows ACS infectious diseases 2 (10), 674-681, 2016 | 135 | 2016 |
Interplay of guanine oxidation and G-quadruplex folding in gene promoters AM Fleming, CJ Burrows Journal of the American Chemical Society 142 (3), 1115-1136, 2019 | 125 | 2019 |
Nanopore detection of 8-oxo-7, 8-dihydro-2′-deoxyguanosine in immobilized single-stranded DNA via adduct formation to the DNA damage site AEP Schibel, N An, Q Jin, AM Fleming, CJ Burrows, HS White Journal of the American Chemical Society 132 (51), 17992-17995, 2010 | 122 | 2010 |
4n–1 Is a “Sweet Spot” in DNA i-Motif Folding of 2′-Deoxycytidine Homopolymers AM Fleming, Y Ding, RA Rogers, J Zhu, J Zhu, AD Burton, CB Carlisle, ... Journal of the American Chemical Society 139 (13), 4682-4689, 2017 | 119 | 2017 |
Formation and processing of DNA damage substrates for the hNEIL enzymes AM Fleming, CJ Burrows Free Radical Biology and Medicine 107, 35-52, 2017 | 117 | 2017 |
Crown ether–electrolyte interactions permit nanopore detection of individual DNA abasic sites in single molecules N An, AM Fleming, HS White, CJ Burrows Proceedings of the National Academy of Sciences 109 (29), 11504-11509, 2012 | 116 | 2012 |
Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia Y Sejersted, GA Hildrestrand, D Kunke, V Rolseth, SZ Krokeide, ... Proceedings of the National Academy of Sciences 108 (46), 18802-18807, 2011 | 112 | 2011 |
Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin SZ Krokeide, JK Laerdahl, M Salah, L Luna, FH Cederkvist, AM Fleming, ... DNA repair 12 (12), 1159-1164, 2013 | 109 | 2013 |
8-Oxo-7, 8-dihydroguanine in the context of a gene promoter G-quadruplex is an on–off switch for transcription AM Fleming, J Zhu, Y Ding, CJ Burrows ACS chemical biology 12 (9), 2417-2426, 2017 | 99 | 2017 |
Unzipping kinetics of duplex DNA containing oxidized lesions in an α-hemolysin nanopore Q Jin, AM Fleming, CJ Burrows, HS White Journal of the American Chemical Society 134 (26), 11006-11011, 2012 | 96 | 2012 |
Structural context effects in the oxidation of 8-oxo-7, 8-dihydro-2′-deoxyguanosine to hydantoin products: electrostatics, base stacking, and base pairing AM Fleming, JG Muller, AC Dlouhy, CJ Burrows Journal of the American Chemical Society 134 (36), 15091-15102, 2012 | 93 | 2012 |
Nanopore detection of 8-oxoguanine in the human telomere repeat sequence N An, AM Fleming, HS White, CJ Burrows ACS nano 9 (4), 4296-4307, 2015 | 92 | 2015 |