Laura Ferraiuolo
Laura Ferraiuolo
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Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis
L Ferraiuolo, J Kirby, AJ Grierson, M Sendtner, PJ Shaw
Nature Reviews Neurology 7 (11), 616-630, 2011
Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis
AE Frakes, L Ferraiuolo, AM Haidet-Phillips, L Schmelzer, L Braun, ...
Neuron 81 (5), 1009-1023, 2014
The C9orf72 protein interacts with Rab1a and the ULK 1 complex to regulate initiation of autophagy
CP Webster, EF Smith, CS Bauer, A Moller, GM Hautbergue, L Ferraiuolo, ...
The EMBO journal 35 (15), 1656-1676, 2016
Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS
K Meyer, L Ferraiuolo, CJ Miranda, S Likhite, S McElroy, S Renusch, ...
Proceedings of the National Academy of Sciences 111 (2), 829-832, 2014
Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS)
LE Cox, L Ferraiuolo, EF Goodall, PR Heath, A Higginbottom, H Mortiboys, ...
PloS one 5 (3), e9872, 2010
Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS
L Ferraiuolo, PR Heath, H Holden, P Kasher, J Kirby, PJ Shaw
Journal of Neuroscience 27 (34), 9201-9219, 2007
Gene expression profiling in human neurodegenerative disease
J Cooper-Knock, J Kirby, L Ferraiuolo, PR Heath, M Rattray, PJ Shaw
Nature Reviews Neurology 8 (9), 518-530, 2012
Improving single injection CSF delivery of AAV9-mediated gene therapy for SMA: a dose–response study in mice and nonhuman primates
K Meyer, L Ferraiuolo, L Schmelzer, L Braun, V McGovern, S Likhite, ...
Molecular Therapy 23 (3), 477-487, 2015
Therapeutic AAV9-mediated suppression of mutant SOD1 slows disease progression and extends survival in models of inherited ALS
KD Foust, DL Salazar, S Likhite, L Ferraiuolo, D Ditsworth, H Ilieva, ...
Molecular Therapy 21 (12), 2148-2159, 2013
Dysregulation of astrocyte–motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis
L Ferraiuolo, A Higginbottom, PR Heath, S Barber, D Greenald, J Kirby, ...
Brain 134 (9), 2627-2641, 2011
Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism
L Ferraiuolo, K Meyer, TW Sherwood, J Vick, S Likhite, A Frakes, ...
Proceedings of the National Academy of Sciences 113 (42), E6496-E6505, 2016
Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS
S Sun, Y Sun, SC Ling, L Ferraiuolo, M McAlonis-Downes, Y Zou, ...
Proceedings of the National Academy of Sciences 112 (50), E6993-E7002, 2015
Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex
GM Thomsen, G Gowing, J Latter, M Chen, JP Vit, K Staggenborg, ...
Journal of Neuroscience 34 (47), 15587-15600, 2014
Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis
SW Song, CJ Miranda, L Braun, K Meyer, AE Frakes, L Ferraiuolo, ...
Nature medicine 22 (4), 397-403, 2016
Loss of nuclear TDP‐43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones
JR Highley, J Kirby, JA Jansweijer, PS Webb, CA Hewamadduma, ...
Neuropathology and applied neurobiology 40 (6), 670-685, 2014
Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis
J Kirby, K Ning, L Ferraiuolo, PR Heath, A Ismail, SW Kuo, CF Valori, ...
Brain 134 (2), 506-517, 2011
SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits
GM Hautbergue, LM Castelli, L Ferraiuolo, A Sanchez-Martinez, ...
Nature communications 8 (1), 1-18, 2017
Transcriptomic indices of fast and slow disease progression in two mouse models of amyotrophic lateral sclerosis
G Nardo, R Iennaco, N Fusi, PR Heath, M Marino, MC Trolese, ...
Brain 136 (11), 3305-3332, 2013
Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS
A Varcianna, MA Myszczynska, LM Castelli, B O'Neill, Y Kim, J Talbot, ...
EBioMedicine 40, 626-635, 2019
Differences in protein quality control correlate with phenotype variability in 2 mouse models of familial amyotrophic lateral sclerosis
M Marino, S Papa, V Crippa, G Nardo, M Peviani, C Cheroni, MC Trolese, ...
Neurobiology of Aging 36 (1), 492-504, 2015
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