| NAD+ cleavage activity by animal and plant TIR domains in cell death pathways S Horsefield, H Burdett, X Zhang, MK Manik, Y Shi, J Chen, T Qi, J Gilley, ... Science 365 (6455), 793-799, 2019 | 398 | 2019 |
| SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration MD Figley, W Gu, JD Nanson, Y Shi, Y Sasaki, K Cunnea, AK Malde, X Jia, ... Neuron 109 (7), 1118-1136. e11, 2021 | 197 | 2021 |
| Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules Y Shi, PS Kerry, JD Nanson, T Bosanac, Y Sasaki, R Krauss, FK Saikot, ... Molecular cell 82 (9), 1643-1659. e10, 2022 | 71 | 2022 |
| Cyclic ADP ribose isomers: production, chemical structures, and immune signaling MK Manik, Y Shi, S Li, MA Zaydman, N Damaraju, S Eastman, TG Smith, ... Science 377 (6614), eadc8969, 2022 | 64 | 2022 |
| A novel NAD signaling mechanism in axon degeneration and its relationship to innate immunity EL Hopkins, W Gu, B Kobe, MP Coleman Frontiers in Molecular Biosciences 8, 703532, 2021 | 34 | 2021 |
| Structural evolution of TIR-domain signalosomes S Nimma, W Gu, N Maruta, Y Li, M Pan, FK Saikot, BYJ Lim, ... Frontiers in Immunology 12, 784484, 2021 | 30 | 2021 |
| Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1 A Loreto, C Angeletti, W Gu, A Osborne, B Nieuwenhuis, J Gilley, ... Elife 10, e72823, 2021 | 29 | 2021 |
| Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection Y Sasaki, J Zhu, Y Shi, W Gu, B Kobe, T Ve, A DiAntonio, J Milbrandt Experimental Neurology 345, 113842, 2021 | 24 | 2021 |
| Potent activation of SARM1 by NMN analogue VMN underlies vacor neurotoxicity A Loreto, C Angeletti, W Gu, A Osborne, B Nieuwenhuis, J Gilley, ... BioRxiv, 2020.09. 18.304261, 2020 | 15 | 2020 |
| Chemical structures of cyclic ADP ribose (cADPR) isomers and the molecular basis of their production and signaling MK Manik, Y Shi, S Li, MA Zaydman, N Damaraju, S Eastman, TG Smith, ... BioRxiv, 2022.05. 07.491051, 2022 | 9 | 2022 |
| Sarm1-dependent axon degeneration: Nucleotide signaling, neurodegenerative disorders, toxicity, and therapeutic opportunities HY McGuinness, W Gu, Y Shi, B Kobe, T Ve The Neuroscientist, 10738584231162508, 2023 | 7 | 2023 |
| Crystal structure of the Toll/interleukin‐1 receptor (TIR) domain of IL‐1R10 provides structural insights into TIR domain signalling S Nimma, W Gu, MK Manik, T Ve, JD Nanson, B Kobe FEBS letters 596 (7), 886-897, 2022 | 6 | 2022 |
| Crystal structure determination of the armadillo repeat domain of Drosophila SARM1 using MIRAS phasing W Gu, Z Luo, C Vonrhein, X Jia, T Ve, JD Nanson, B Kobe Acta Crystallographica Section F: Structural Biology Communications 77 (10 …, 2021 | 4 | 2021 |
| Crystal and Cryo-EM structures provide insight into how pro-neurodegenerative SARM1 is activated and cleave NAD T Ve, W Gu, J Nanson, Y Shi, K Cunnea, P Kerry, T Bosanac, R Hughes, ... Acta Crystallographica Section A: Foundations and Advances 77, C431-C431, 2021 | | 2021 |
| Structural basis of SARM1 regulation W Gu | | 2020 |
| Crystal structure of the TIR domain of IL-1R10 provides structural 2 insights into TIR domain signaling S Nimma, W Gu, MK Manik, T Ve, JD Nanson, B Kobe | | |
| Full wwPDB X-ray Structure Validation Report i○ S Horsefield, H Burdett, X Zhang, MK Manik, Y Shi, J Chen, Q Tiancong, ... | | |
| Full wwPDB X-ray Structure Validation Report i○ Y Hai, JE Edwards, MC Van Zandt, KF Hoffmann, DW Christianson | | |
