Follow
Bruce Xue Wen Wong
Bruce Xue Wen Wong
Research Associate, University of Cambridge, ARUK Drug Discovery Institute
Verified email at medschl.cam.ac.uk
Title
Cited by
Cited by
Year
Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
P Lei, S Ayton, DI Finkelstein, L Spoerri, GD Ciccotosto, DK Wright, ...
Nature medicine 18 (2), 291-295, 2012
6192012
Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease
S Ayton, P Lei, JA Duce, BXW Wong, A Sedjahtera, PA Adlard, AI Bush, ...
Annals of neurology 73 (4), 554-559, 2013
2682013
β-Amyloid precursor protein does not possess ferroxidase activity but does stabilize the cell surface ferrous iron exporter ferroportin
BX Wong, A Tsatsanis, LQ Lim, PA Adlard, AI Bush, JA Duce
PloS one 9 (12), e114174, 2014
1562014
Amyloid-β peptide Aβ3pE-42 induces lipid peroxidation, membrane permeabilization, and calcium influx in neurons
AP Gunn, BX Wong, T Johanssen, JC Griffith, CL Masters, AI Bush, ...
Journal of Biological Chemistry 291 (12), 6134-6145, 2016
932016
Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson’s disease
JA Duce, BX Wong, H Durham, JC Devedjian, DP Smith, D Devos
Molecular neurodegeneration 12, 1-12, 2017
692017
Marked age-related changes in brain iron homeostasis in amyloid protein precursor knockout mice
AA Belaidi, AP Gunn, BX Wong, S Ayton, AT Appukuttan, BR Roberts, ...
Neurotherapeutics 15, 1055-1062, 2018
572018
Amyloidogenic processing of Alzheimer’s disease β-amyloid precursor protein induces cellular iron retention
A Tsatsanis, BX Wong, AP Gunn, S Ayton, AI Bush, D Devos, JA Duce
Molecular psychiatry 25 (9), 1958-1966, 2020
562020
The iron regulatory capability of the major protein participants in prevalent neurodegenerative disorders
BX Wong, JA Duce
Frontiers in pharmacology 5, 88358, 2014
562014
Metals and cholesterol: two sides of the same coin in Alzheimer’s disease pathology
BX Wong, YH Hung, AI Bush, JA Duce
Frontiers in Aging Neuroscience 6, 91, 2014
502014
Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta
MIG Lopez Sanchez, HS Waugh, A Tsatsanis, BX Wong, JG Crowston, ...
Scientific reports 7 (1), 9835, 2017
432017
P2X7 receptor-mediated scavenger activity of mononuclear phagocytes toward non-opsonized particles and apoptotic cells is inhibited by serum glycoproteins but remains active in …
BJ Gu, JA Duce, VA Valova, B Wong, AI Bush, S Petrou, JS Wiley
Journal of Biological Chemistry 287 (21), 17318-17330, 2012
352012
Post translational modulation of β-amyloid precursor protein trafficking to the cell surface alters neuronal iron homeostasis
A Tsatsanis, S Dickens, JCF Kwok, BX Wong, JA Duce
Neurochemical Research 44, 1367-1374, 2019
322019
A comparison of ceruloplasmin to biological polyanions in promoting the oxidation of Fe2+ under physiologically relevant conditions
BX Wong, S Ayton, LQ Lam, P Lei, PA Adlard, AI Bush, JA Duce
Biochimica et Biophysica Acta (BBA)-General Subjects 1840 (12), 3299-3310, 2014
312014
The acute phase protein lactoferrin is a key feature of Alzheimer’s disease and predictor of Aβ burden through induction of APP amyloidogenic processing
A Tsatsanis, AN McCorkindale, BX Wong, E Patrick, TM Ryan, RW Evans, ...
Molecular psychiatry 26 (10), 5516-5531, 2021
302021
Dyslipidemic diabetic serum increases lipid accumulation and expression of stearoyl-CoA desaturase in human macrophages
BXW Wong, RA Kyle, PC Myhill, KD Croft, CM Quinn, W Jessup, BB Yeap
Lipids 46, 931-941, 2011
172011
Modulation of macrophage fatty acid content and composition by exposure to dyslipidemic serum in vitro
BXW Wong, RA Kyle, KD Croft, CM Quinn, W Jessup, BB Yeap
Lipids 46, 371-380, 2011
162011
Increased glutaminyl cyclase activity in brains of Alzheimer’s disease individuals
AP Gunn, BX Wong, C McLean, C Fowler, PJ Barnard, JA Duce, ...
Journal of Neurochemistry 156 (6), 979-987, 2021
132021
Oxidation of Iron under physiologically relevant conditions in biological fluids from healthy and Alzheimer’s Disease subjects
LQ Lam, BX Wong, T Frugier, QX Li, SJ Collins, AI Bush, PJ Crack, ...
ACS Chemical Neuroscience 8 (4), 731-736, 2017
32017
Pharmacological inhibition of STING reduces neuroinflammation-mediated damage post-traumatic brain injury
A Fryer, A Abdullah, F Mobilio, Z Moore, G Zheng, M de Veer, B Wong, ...
Authorea Preprints, 2023
2023
Innate immune response protein lactoferrin directly binds amyloid-beta precursor protein to promote amyloidogenic processing
A Tsatsanis, T Ryan, B Wong, R Evans, A Bush, J Duce
JOURNAL OF NEUROCHEMISTRY 142, 66-66, 2017
2017
The system can't perform the operation now. Try again later.
Articles 1–20